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Resveratrol and Alzheimer’s Disease: Mechanistic Insights

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Abstract

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of AD include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of AD, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3,5,4′-trihydroxy-trans-stilbene) have been investigated in several in vitro and in vivo models of AD. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of AD. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol have also been addressed.

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Authors and Affiliations

  1. Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan

    Touqeer Ahmed, Sehrish Javed, Sana Javed & Ameema Tariq

  2. Department of Molecular Biology, Institute ‘Ruđer Bošković’, Bijenička c. 54, P.O. Box 180, 10000, Zagreb, Croatia

    Dunja Šamec

  3. Experimental Laboratory, Research Unit, Son Llàtzer Hospital, IUNICS, Ctra. Manacor km 4, 07198, Palma de Mallorca, Balearic Islands, Spain

    Silvia Tejada

  4. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19395-5487, Tehran, Iran

    Seyed Fazel Nabavi & Seyed Mohammad Nabavi

  5. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia

    Nady Braidy

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Ahmed, T., Javed, S., Javed, S. et al. Resveratrol and Alzheimer’s Disease: Mechanistic Insights. Mol Neurobiol 54, 2622–2635 (2017). https://doi.org/10.1007/s12035-016-9839-9

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