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Synthesis and characterization of inherently radiopaque nanocomposites using biocompatible iodinated poly(methyl methacrylate-co-acrylamide) and graphene oxide

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Abstract

New inherently radiopaque nanocomposites were prepared using iodine-containing poly(methyl methacrylate-co-acrylamide) and graphene oxide. For this purpose, P(MMA-co-AA) was synthesized via copolymerization of methyl methacrylate and acrylic acid, and modified with 4-iodophenyl isocyanate and 3,4,5-triiodophenyl isocyanate to form poly[(methyl methacrylate-co-(N-4-iodophenyl)acrylamide)] (1I-P(MMA-co-AA)) and poly[(methyl methacrylate-co-(N-3,4,5-triiodophenyl)acrylamide)] (3I-P(MMA-co-AA)), respectively. For comparative evaluation, the non-iodinated copolymer (PIC-P(MMA-co-AA)) was prepared via reaction of the P(MMA-co-AA) with phenyl isocyanate to investigate the effect of iodinated substituents on the morphology and thermal characteristics of the nanocomposites. All the nanocomposites were characterized by X-ray diffraction analysis, scanning electron microscopy, X-radiography and thermogravimetric analysis. The results proved that thermal properties of the nanocomposites improved by the introduction of different amounts of graphene oxide into the copolymers’ matrix. Radiopacity measurements showed the excellent radiopacity of iodinated nanocomposites and proved that 3I-GO-5 had radiopacity equivalent to that of an aluminium wedge with 2-mm thickness.

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Acknowledgements

The authors would like to thank the ‘Clinical Research Development Center of Baqiyatallah Hospital’ for their kindly cooperation. The financial support of Shahrood University of Technology is gratefully acknowledged (Grant Number 50/3786).

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Authors and Affiliations

  1. School of Chemistry, Shahrood University of Technology, Shahrood, Iran

    Saeed Shiralizadeh, Hossein Nasr-Isfahani & Amir Hossein Amin

  2. Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, PO Box 89195-999, Yazd, Iran

    Mostafa Azimzadeh

  3. Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, PO Box 89195-999, Yazd, Iran

    Mostafa Azimzadeh

  4. Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, 8916188635, Iran

    Mostafa Azimzadeh

  5. Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Ramezan Ali Taheri

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  1. Saeed Shiralizadeh
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  2. Hossein Nasr-Isfahani
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  3. Amir Hossein Amin
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  4. Mostafa Azimzadeh
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Correspondence to Ramezan Ali Taheri.

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Shiralizadeh, S., Nasr-Isfahani, H., Amin, A.H. et al. Synthesis and characterization of inherently radiopaque nanocomposites using biocompatible iodinated poly(methyl methacrylate-co-acrylamide) and graphene oxide. Bull Mater Sci 43, 42 (2020). https://doi.org/10.1007/s12034-019-1999-6

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  • DOI: https://doi.org/10.1007/s12034-019-1999-6

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