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Polysulphone composite membranes modified with two types of carbon additives as a potential material for bone tissue regeneration

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Abstract

This study presents a detailed evaluation of the impact of carbon fibrous materials on the physicochemical properties of polysulphone (PSU) membranes and their preliminary osteoblast-like cells response in vitro. Multi-walled carbon nanotubes (MWCNTs) and short carbon fibres (SCFs) were incorporated into PSU and membranes were produced by the phase inversion method. Then, the physicochemical properties of the membranes’ surface were investigated. Scanning electron microscopy (SEM) was used to evaluate microstructure and porosity. Surface properties such as roughness, wettability and surface energy were evaluated using atomic force microscopy (AFM), contact profilometry and a goniometer, respectively. The presence of carbon fibrous additives in the PSU matrix improved its hydrophilicity. Porosity and topography of the PSU membranes were also changed upon incorporation of carbon additives. The mechanical properties of the PSU membranes were improved after SCF addition. All physicochemical properties of the obtained composite membranes had significant impact on the osteoblast-like cells response. Preliminary viability tests indicated biocompatibility of all membranes.

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Acknowledgements

The study was financed from the statute funds of AGH-UST, Faculty of Materials Engineering and Ceramics, Project no.11.11.160.616. M T acknowledges the financial support from the U.S. Air Force Office of Scientific Research, through MURI grant FA9550-12-1-0035.

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Authors and Affiliations

  1. AGH-University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Biomaterials, Al. Mickiewicza 30, 30-059, Krakow, Poland

    ALICJA WEDEL-GRZENDA, ANETA FRACZEK-SZCZYPTA & STANISLAW BLAZEWICZ

  2. The Pennsylvania State University, Department of Physics and Center for 2-Dimensional and Layered Materials, 104 Davey Laboratory, University Park, PA, 16802, USA

    MAURICIO TERRONES & ANA LAURA ELÍAS

  3. Shinshu University, Research Center for Exotic Nanocarbons (JST), Wakasato 4-17-1, Nagano-city, 380-8553, Japan

    MAURICIO TERRONES

  4. The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences; Department of Experimental Physics of Complex Systems, Laboratory of Biophysical Microstructures, Radzikowskiego 52, 31-342, Krakow, Poland

    MALGORZATA LEKKA

  5. Collegium Medicum, Jagiellonian University, Faculty of Pharmacy, Department of Cytobiology, Medyczna 9, 30-068, Krakow, Poland

    ELZBIETA MENASZEK

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  1. ALICJA WEDEL-GRZENDA
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Correspondence to ANETA FRACZEK-SZCZYPTA.

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WEDEL-GRZENDA, A., FRACZEK-SZCZYPTA, A., TERRONES, M. et al. Polysulphone composite membranes modified with two types of carbon additives as a potential material for bone tissue regeneration. Bull Mater Sci 40, 201–212 (2017). https://doi.org/10.1007/s12034-017-1360-x

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  • DOI: https://doi.org/10.1007/s12034-017-1360-x

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