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Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers

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Abstract

Due to their biological activities in regulating dosage compensation, epigenetics, and cell differentiation, long non-coding RNAs (lncRNA) have been recognized as important regulators of the beginning and development of human malignancies. LncRNA dysregulation has a significant impact on a range of cellular functions, including proliferation, migration, invasion, and anti-apoptosis activity. Recently, aberrant expression of the long non-coding RNA zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) was observed in a range of solid tumors and correlated significantly with tumor size, histological differentiation, lymph node metastasis, malignant tumor (TNM) stage, short survival, and prognosis. Additional mechanical analysis indicated that ZFPM2-AS1 was involved in several cellular activities, including proliferation, migration, invasion, cell cycle progression, and apoptosis, through microRNAs (miRNAs), signaling pathways, and other biological components or proteins. This review summarizes the current status of research on ZFPM2-AS1 in various human malignancies and discusses its mechanism of action and clinical significance in tumor development and progression.

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Abbreviations

BC:

Breast cancer

ceRNA:

Competitive endogenous RNA

CRC:

Colorectal cancer

ESCC:

Esophageal squamous cell carcinoma

GC:

Gastric cancer

GEO:

Gene expression omnibus

GEPIA:

Gene expression profile interactive analysis

GSEA:

Gene set enrichment analysis

HCC:

Hepatocellular carcinoma

LAUD:

Lung adenocarcinoma

lncRNA:

Long non-coding RNA

miRNA:

Micro RNA

MMM:

Malignant melanoma

NSCLC:

Non-small cell lung cancer

OS:

Overall survival

RB:

Retinoblastoma

SCLC:

Small cell lung cancer

TC:

Thyroid cancer

TCGA:

The cancer genome atlas

ZFPM2-AS1:

Zinc finger protein multitype 2 antisense RNA 1

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Funding

This work was supported by the Foundation of Science technology Department of Zhejiang Province, China social development projects (LGF21C050001).

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Authors and Affiliations

  1. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, 310018, Hangzhou, People’s Republic of China

    Gabriel B. K. Sasa, Cheng Xuan & Xianfeng Ding

  2. Zhejiang Sci-Tech University Library, Hangzhou, 310018, People’s Republic of China

    Guoliang Lyu

  3. Department of Rare and Head and Neck Oncology, Key Laboratory of Head and Neck Cancer, Translational Research of Zhejiang Province, Hangzhou, People’s Republic of China

    Fang Meiyu

  4. Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, People’s Republic of China

    Fang Meiyu

  5. Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China

    Fang Meiyu

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  1. Gabriel B. K. Sasa
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Sasa, G.B.K., Xuan, C., Lyu, G. et al. Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers. Mol Biotechnol 64, 725–742 (2022). https://doi.org/10.1007/s12033-021-00443-3

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