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Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population

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An Erratum to this article was published on 12 August 2011

Abstract

Colorectal cancer (CRC) is among the major causes of cancer-related morbidity, mortality, and human health problem worldwide. Single-nucleotide polymorphisms (SNPs) in different genes are reported to be effective in increased risk of CRC in different ethnic population. We conducted a case–control study in patients diagnosed with sporadic colorectal cancer (n = 115) and healthy controls based on colonoscopy evidences (n = 120).In this replicative study, we aimed to investigate the association of two previously reported polymorphisms, rs6983267 and rs4444903, with sporadic colorectal cancer in a subset of Iranian patients. Genotyping was performed via polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) assay. A significant relation was found between rs6983267 variant in the 8q24 region and colorectal cancer. The distribution of G/G genotypes among sporadic CRC patients was more frequent than that in the control group (P value = 0.001). The frequency of the G allele in the colorectal cancer patient group was also higher than that in the control group (65% vs. 48%; P value = 0.001). Compared with GG genotype, individuals with G/T and T/T genotypes had lower risk to develop sporadic CRC (OR = 0.357, 95% CI = 0.201–0.635). For the rs4444903 SNP, no significant association (P value = 0.149) was found with colorectal cancer risk. In conclusion, our findings suggest that the 8q24 rs6983267 SNP may play a pivotal role in the development of sporadic CRC in Iranian population. Therefore, it may be included as a potential genetic susceptibility marker for sporadic CRC.

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Acknowledgments

We gratefully acknowledge the cooperation of the stuff of seyed al shohada hospital and Poursina Hakim Research Institute, for sample collection. We are also thankful to the Vice-Chancellor for Research for financial support.

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Authors and Affiliations

  1. Department of Biomedical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    A. Daraei, R. Salehi, M. Salehi & F. Mohamadhashem

  2. Isfahan University of Medical Sciences, Isfahan, Iran

    M. H. Emami & H. Tavakoli

  3. Poursina Hakim Research Institute, Isfahan, Iran

    M. H. Emami & H. Tavakoli

  4. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

    M. Jonghorbani

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  1. A. Daraei
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  2. R. Salehi
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  4. M. H. Emami
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Correspondence to R. Salehi.

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Daraei, A., Salehi, R., Salehi, M. et al. Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population. Med Oncol 29, 1044–1049 (2012). https://doi.org/10.1007/s12032-011-9980-2

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  • DOI: https://doi.org/10.1007/s12032-011-9980-2

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