Abstract
Duchenne muscular dystrophy (DMD) is a condition caused by an amendment to the X chromosome, inherited as a recessive trait, and affects 1:3500 live births, especially males. Low-intensity exercise is known to decrease certain parameters associated with muscular degeneration in animal models of progressive muscular dystrophies. In the present study, 28-day-old male mdx and wild-type (wild) mice were used. The animals were subjected to a low-intensity physical exercise protocol for 8 weeks. It was found that this protocol was able to reduce oxidative stress in muscle tissue and in most of the CNS structures analyzed, with a significant increase in antioxidant activity in all analyzed structures. It is thus possible to infer that this exercise protocol was able to reduce oxidative stress and improve the energy metabolism in brain tissue and in the gastrocnemius muscle of animals with DMD.
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Acknowledgements
This research was supported by grants from UNESC (PCLS) and UNISUL (CMC).
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Andreza Hoepers, Adriano Alberti, Viviane Freiberger, Letícia Ventura, Leoberto Ricardo Grigollo, Cristina Salar Andreau, Bruna Becker da Silva, Daniel Fernandes Martins, Rudy José Nodari Junior, Emilio L. Streck, Clarissa M. Comim.
The first draft of the manuscript was written by Andreza Hoepers and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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All procedures were performed in compliance with the Brazilian Society of Neuroscience. This project was approved of by the Animal Use Ethics Committee (CEUA) of Unisul under number 14.017.4.08.IV.
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Hoepers, A., Alberti, A., Freiberger, V. et al. Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy. J Mol Neurosci 70, 1552–1564 (2020). https://doi.org/10.1007/s12031-020-01565-0
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DOI: https://doi.org/10.1007/s12031-020-01565-0