Skip to main content

Advertisement

SpringerLink
Log in

Higher Serum Uric Acid May Contribute to Cerebral Infarction in Patients with Type 2 Diabetes Mellitus: a Meta-Analysis

  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

Abstract

Higher levels of serum uric acid tend to increase the diabetes-related complications. We performed a meta-analysis to investigate whether the higher serum uric acid levels were associated with cerebral infarction in type 2 diabetes patients. We searched for relevant studies in the PubMed, Embase, China National Knowledge Infrastructure, China BioMedicine, and VIP database until August 2015. All observational studies comparing serum uric acid levels in type 2 diabetic patients with and without cerebral infarction were included. We calculated the ratio of means (RoM) of serum uric acid by mean cerebral infarction/mean diabetic control from the individual studies and then pooled RoM and its 95 % confidence intervals (CI). A total of 23 eligible studies were identified. Pooled estimates indicated that type 2 diabetes patients with cerebral infarction were associated with 29 % (RoM 1.29; 95 % CI 1.26–1.31) higher serum uric acid levels than those without cerebral infarction in a random effect model. Subgroup analyses based on gender indicated that RoM was 1.23 (95 % CI 1.09–1.38) for men and 1.12 (95 % CI 0.98–1.27) for women. This meta-analysis suggests that higher serum uric acid levels may contribute to cerebral infarction in patients with type 2 diabetes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Adamopoulos D, Vlassopoulos C, Seitanides B, Contoyiannis P, Vassilopoulos P (1977) The relationship of sex steroids to uric acid levels in plasma and urine. Acta Endocrinol (Copenh) 85:198–208

    CAS  Google Scholar 

  • Association AD (2015) Standards of medical care in diabetes-2015 abridged for primary care providers. Clin Diabetes 33:97–111

    Article  Google Scholar 

  • Athyros VG, Mikhailidis DP (2016) High incidence of metabolic syndrome further increases cardiovascular risk in patients with type 2 diabetes. Implications for everyday practice. J Diabetes Complicat 30:9–11

    Article  PubMed  Google Scholar 

  • Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101

    Article  CAS  PubMed  Google Scholar 

  • Cai HR, Luo LL, Li B (2011) Significance of measurement of serum uric acid in type 2 diabetes mellitus with cerebral infarction. Hainan Med J 22:105–106

    Google Scholar 

  • Chen C (2014) The level of uric acid in type 2 diabetic patients with cerebral infarction. J Bengbu Med Coll 39:1647–1648

    CAS  Google Scholar 

  • Culleton BF (2001) Uric acid and cardiovascular disease: a renal-cardiac relationship? Curr Opin Nephrol Hypertens 10:371–375

    Article  CAS  PubMed  Google Scholar 

  • Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fang J, Alderman MH (2000) Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National Health and Nutrition Examination Survey. JAMA 283:2404–2410

    Article  CAS  PubMed  Google Scholar 

  • Friedrich JO, Adhikari NK, Beyene J (2011) Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods. J Clin Epidemiol 64:556–564

    Article  PubMed  Google Scholar 

  • Fu XS (2001) Clinical observation of serum calcium and uric acid level in patients with type 2 diabetes mellitus complicated acute cerebral infarction. Jiangsu J Prev Med 12:15–16

  • Gregg EW et al (2014) Changes in diabetes-related complications in the United States, 1990–2010. N Engl J Med 370:1514–1523

    Article  CAS  PubMed  Google Scholar 

  • Guan MP, Xue YM, Shen J, Zhou L, Gao F, Liu SQ, Li CZ (2002) Serum uric acid in type 2 diabetic patients complicated by stroke. Acad J First Military Med Univ 22:70–71

    CAS  Google Scholar 

  • Guo D (2014) Serum uric acid level on the short-term clinical effect of 2 type diabetes mellitus complicated with cerebral infarction. Chin J Pharm Ecol 9:92–93

    Google Scholar 

  • Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ (2013) The role of uric acid in the pathogenesis of human cardiovascular disease. Heart 99:759–766

    Article  CAS  PubMed  Google Scholar 

  • Lehto S, Niskanen L, Ronnemaa T, Laakso M (1998) Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke 29:635–639

    Article  CAS  PubMed  Google Scholar 

  • Li YM (2007) Biochemical parameters and correlation analysis of type 2 diabetic patients complicated with cerebral infarction. J Clin Res 24:649–650

    Google Scholar 

  • Li Y, Zhang L, Zhu DF (2005) Study on the changes of Serum uric acid, lipids and insulin sensitive index in elderly type-2 diabetic patients with asymptomatic cerebral infarction. Chin J Clin Heath 8:203–205

    CAS  Google Scholar 

  • Li M, Hou W, Zhang X, Hu L, Tang Z (2014) Hyperuricemia and risk of stroke: a systematic review and meta-analysis of prospective studies. Atherosclerosis 232:265–270

    Article  CAS  PubMed  Google Scholar 

  • Liang D (2007) Exploration of relation between serum levels of uric acid and lipids and type 2 diabetes mellitus associated with acute cerebral infarction. Chin J Modern Med 17:712–714

    CAS  Google Scholar 

  • Newman EJ, Rahman FS, Lees KR, Weir CJ, Walters MR (2006) Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes. Diabetes Metab Res Rev 22:79–82

    Article  CAS  PubMed  Google Scholar 

  • Niu DW (2012) Clinical observation of type 2 diabetes mellitus complicated with cerebral infarction. Chin Manip Rehab Med 3:105–106

    Google Scholar 

  • Peters SA, Huxley RR, Woodward M (2014) Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775,385 individuals and 12,539 strokes. Lancet 383:1973–1980

    Article  PubMed  Google Scholar 

  • Ray KK et al (2009) Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet 373:1765–1772

    Article  CAS  PubMed  Google Scholar 

  • Rong J (2012) Clinical significance of blood rheology analysis combined with serum uric add in patients with diabetes complicated with cerebral infarction. Pract Geriatr 26:135–136

    CAS  Google Scholar 

  • Sarwar N et al (2010) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 375:2215–2222

    Article  CAS  PubMed  Google Scholar 

  • Shi J, Wang CW, Liu H (2000) Changes of serum uric acid in elderly patients with type 2 diabetes mellitus with cerebral infarction. Prac Geriatr 14:40

    Google Scholar 

  • Song NY, Liu B, Hu XH (2006) The relationship between hyperuricemia and brain infarction in aged type 2 diabetes mellitus. Acta Acad Med Jiangxi 46:93–95

    CAS  Google Scholar 

  • Tziomalos K et al (2014) Type 2 diabetes is associated with a worse functional outcome of ischemic stroke. World J Diabetes 5:939–944

    Article  PubMed  PubMed Central  Google Scholar 

  • Wan JW, Liu BW (2008) Relationship between patients with type 2 diabetes mellitus complicated cerebral infarction and serum uric acid level. Hebei Med J 30:1149–1150

    Google Scholar 

  • Wei XY (2005) Changes of serum uric acid in patients of type 2 diabetes complicated with cerebral infarction. Acta Med Sinica 18:514–515

    Google Scholar 

  • Weinstock RS, Drews KL, Caprio S, Leibel NI, McKay SV, Zeitler PS (2015) Metabolic syndrome is common and persistent in youth-onset type 2 diabetes: results from the TODAY clinical trial. Obesity (Silver Spring) 23:1357–1361

    Article  Google Scholar 

  • Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P The Newcastle–Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 20 Dec 2015

  • Xu Y et al (2013) Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PLoS One 8:e78206

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yan WL, Qu RM, Dong H (2002) Serum uric acid predicts cerebral infarction risk in noninsulin dependent diabetic patients. Clin Focus 17:408–409

    Google Scholar 

  • Yang CX, Mi XB, Wei P, He Q, Xi ZP, Wang FR (2014) Correlation analysis of serum homocysteine, uric acid and glycosylated hemoglobin in elderly patients with type 2 diabetes mellitus with cerebral infarction. Jilin Med J 35:5662–5663

    CAS  Google Scholar 

  • Yao WQ (2007) Investigation on the relationship between uric acid and cerebral infarct on patients with type 2 diabetes mellitus. Chin Med Digest Intern Med 2:505–507

    Google Scholar 

  • Ye ZD, Ma ZY, Yu JN (2002) Relationship between cerebral infarction and serum uric acid level in type 2 diabetic patients. J Guangdong Med Coll 20:21–22

    Google Scholar 

  • Yin XJ, Xia JF, Xia JR (2004) Investigation on the relationship between serum uric acid and cerebral infarction in patients with type 2 diabetes mellitus. Modern Med Heal 20:1836–1837

    Google Scholar 

  • Ying WH (2004) Clinical analysis of 56 cases patients with diabetes mellitus associated with cerebral infarction. Prev Treat Cardio-Cerebralvasc Dis 4:60–61

    Google Scholar 

  • Zhang JY, Niu YQ (2009) Serum uric in type 2 diabetes mellitus in elderly patients and in which compensated by infarction of the brain. Chin Prac Med 4:31–32

    Google Scholar 

  • Zhao J, Chen HQ (2015) A retrospective analysis of risk factors of type 2 diabetes mellitus combined with cerebral infarction. Heal Voca Educ 33:141–142

    Google Scholar 

  • Zhao P, Wu D (2012) Risk factors of cerebral infarction in patients with type s diabetics. Med J Chin People’s Heal 24:1043–1045

    Google Scholar 

  • Zimmet PZ, Magliano DJ, Herman WH, Shaw JE (2014) Diabetes: a 21st century challenge. Lancet Diabetes Endocrinol 2:56–64

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by Natural Science Funds of Xinjiang Uygur Autonomous Region, China (Grant No. 2015211C085).

Author information

Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Xinjiang Medical University, No 137 Liyushannan Road, Urumqi, Xinjiang, 830054, China

    Lei Du, Jianhua Ma & Xiaoning Zhang

Authors
  1. Lei Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jianhua Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiaoning Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaoning Zhang.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Du, L., Ma, J. & Zhang, X. Higher Serum Uric Acid May Contribute to Cerebral Infarction in Patients with Type 2 Diabetes Mellitus: a Meta-Analysis. J Mol Neurosci 61, 25–31 (2017). https://doi.org/10.1007/s12031-016-0848-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12031-016-0848-y

Keywords

Search

Navigation