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Hereditary Pancreatitis Related to SPINK-1 Mutation. Is There an Increased Risk of Developing Pancreatic Cancer?

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Abstract

It is thought that many of the idiopathic pancreatitis could have a genetic base. Approximately 50% of them correspond to CFTR (cystic fibrosis transmembrane conductance regulator gene) and SPINK-1 (serine protease inhibitor Kazal type 1) mutations. A recent study compares patients with acute pancreatitis and SPINK-1 mutation with patients with idiopathic acute pancreatitis. The study highlights a 12-fold increased risk of developing pancreatic cancer with SPINK-1 mutation versus the control group. Nonetheless, authors conclude that only specific pN34s mutation is related to pancreatic cancer. This relation is controversial, and international consensus guidelines for the follow-up in chronic pancreatitis with pancreatic cancer still do not recommend follow-up in SPINK-1 p. N34S mutation. We believe that developing prospective studies in which subgroups of patients with SPINK-1 mutation benefit from closer follow-ups would be necessary.

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Authors and Affiliations

  1. Hospital Universitario Severo Ochoa, Leganes, Madrid, Spain

    Diego T. Enjuto, Norberto Herrera, Antonio Ramos Bonilla, Rosa Llorente-Lázaro, Judit González Guerreiro & Pilar Castro-Carbajo

  2. Hospital Universitario del Henares, Coslada, Madrid, Spain

    Carmen J. Ceinos

Authors
  1. Diego T. Enjuto
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  2. Norberto Herrera
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  3. Carmen J. Ceinos
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  4. Antonio Ramos Bonilla
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  5. Rosa Llorente-Lázaro
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  6. Judit González Guerreiro
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  7. Pilar Castro-Carbajo
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Correspondence to Diego T. Enjuto.

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Enjuto, D.T., Herrera, N., J. Ceinos, C. et al. Hereditary Pancreatitis Related to SPINK-1 Mutation. Is There an Increased Risk of Developing Pancreatic Cancer?. J Gastrointest Canc 54, 268–269 (2023). https://doi.org/10.1007/s12029-021-00729-4

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  • DOI: https://doi.org/10.1007/s12029-021-00729-4

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