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Frequency of Defective Mismatch Repair System in a Series of Consecutive Cases of Colorectal Cancer in a National Cancer Center

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Abstract

Background

The frequency of colorectal cancer (CRC) with defective mismatch repair (dMMR) is estimated between 5 and 15%. In our population, the frequency of dMMR is unknown. Our objective was to show the frequency of dMMR.

Methods

Determination of dMMR with immunohistochemistry was performed prospectively for 202 patients who presented consecutively with CRC for the first time at our institution.

Results

The median age was 59 years (IQR 47 to 68), 119 (58.9%) were women, and 43 (21.3%) cases showed dMMR. The only clinicopathological characteristics associated with dMMR were the location in the right colon and the presence of a family history of cancer. In the multivariate analysis, only the presence of the tumor in the right colon was associated with dMMR (OR = 5.823, 95%-C.I. = 2.653–12.784, p < .001).

Conclusion

The 21.3% of the cases demonstrated a dMMR and the only clinical-pathological characteristic associated with dMMR was location in the right colon.

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Authors and Affiliations

  1. Surgical pathology, Instituto Nacional de Cancerología, Mexico City, Mexico

    Patricia E. López-Correa & Leonardo S. Lino-Silva

  2. Surgical pathology, Fundación Universitaria de Ciencias de la Salud (FUCS), Hospital de San José, Bogotá, Colombia

    Patricia E. López-Correa

  3. Gastrointestinal Pathology Division, Instituto Nacional de Cancerología de México (Mexico’s National Cancer Institute), Av. San Fernando # 22, Sección XVI, Tlalpan, CP 14080, Mexico City, Mexico

    Leonardo S. Lino-Silva

  4. Surgical Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Armando Gamboa-Domínguez

  5. Surgical Oncology, Hospital Ángeles Tijuana, Tijuana, Baja California Norte, Mexico

    César Zepeda-Najar

  6. Surgical oncology, Instituto Nacional de Cancerología, Mexico City, Mexico

    Rosa A. Salcedo-Hernández

Authors
  1. Patricia E. López-Correa
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  2. Leonardo S. Lino-Silva
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  3. Armando Gamboa-Domínguez
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  4. César Zepeda-Najar
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  5. Rosa A. Salcedo-Hernández
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Contributions

All authors meet the criteria for authorship as per the guidelines of the International Committee of Medical Journal Editors (ICMJE); all have participated at (1) the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; (2) drafting the work or revising it critically for important intellectual content; (3) final approval of the version submitted; and (4) Agreement to be accountable for all aspects of the work regarding the accuracy or integrity of the research.

Corresponding author

Correspondence to Leonardo S. Lino-Silva.

Ethics declarations

This study was conducted following the statements of Helsinki declaration and was approved by the Ethics in Investigation Board of our Institution with a waiver of informed consent (see “Material and Methods”).

Conflict of Interest

The authors declare that they have no conflict of interest.

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López-Correa, P.E., Lino-Silva, L.S., Gamboa-Domínguez, A. et al. Frequency of Defective Mismatch Repair System in a Series of Consecutive Cases of Colorectal Cancer in a National Cancer Center. J Gastrointest Canc 49, 379–384 (2018). https://doi.org/10.1007/s12029-018-0132-1

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  • DOI: https://doi.org/10.1007/s12029-018-0132-1

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