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Expression Analysis of Survivin and XIAP in Gallbladder Cancer: a Case-control Study in Indo-Gangetic Plain

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Abstract

Purpose

Gallbladder cancer is a highly mortal disease with poor prognosis because of late presentation of disease. Survivin and X-linked inhibitor of apoptosis (XIAP) are one of the two important members of inhibitors of apoptosis. Thus, this study aimed to look at the expression of Survivin and XIAP in gallbladder cancer patients.

Methods

Survivin and XIAP expression were investigated in tissues of gallbladder cancer patients (40 cases) and compared with cholelithiasis as control (40 cases) by using immunohistochemistry. Their expression was correlated with clinicopathological parameters.

Results

Significantly higher (p < 0.05), Survivin protein was expressed in gallbladder cancer (n = 67.5%) than control (n = 35%). But it did not show any significant association with any of the clinicopathological parameter while XIAP was not expressed in the GBC patients (p > 0.05).

Conclusion

Overexpression of Survivin in gallbladder cancer suggests its possible role and association with poor prognosis. But XIAP has not been found to be associated with gallbladder carcinogenesis.

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Acknowledgements

Departmental research grant for financial support.

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Authors and Affiliations

  1. Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Ruhi Dixit, Mohd Raza, S. Basu & V. K. Shukla

  2. Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

    Mohan Kumar

Authors
  1. Ruhi Dixit
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  2. Mohd Raza
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  3. Mohan Kumar
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  4. S. Basu
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  5. V. K. Shukla
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Correspondence to V. K. Shukla.

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The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Dixit, R., Raza, M., Kumar, M. et al. Expression Analysis of Survivin and XIAP in Gallbladder Cancer: a Case-control Study in Indo-Gangetic Plain. J Gastrointest Canc 49, 487–492 (2018). https://doi.org/10.1007/s12029-017-0008-9

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  • DOI: https://doi.org/10.1007/s12029-017-0008-9

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