Skip to main content
SpringerLink
Log in

Suspended (but No Animation) White’s Isolated Brain Experiments

  • Neurocritical Care Through History
  • Published:
Neurocritical Care Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Vrselja Z, Daniele SG, Silbereis J, et al. Restoration of brain circulation and cellular functions hours post-mortem. Nature. 2019;568(7752):336–43.

    Article  CAS  Google Scholar 

  2. Shaer M. Scientists are giving dead brains new life. What could go wrong? The New York Times Magazine, 7 Jul 2019, p. 29. https://www.nytimes.com/2019/07/02/magazine/dead-pig-brains-reanimation.html.

  3. White RJ, Wolin LR, Massopust LC Jr, Taslitz N, Verdura J. Cephalic exchange transplantation in the monkey. Surgery. 1971;70(1):135–9.

    CAS  PubMed  Google Scholar 

  4. Bremer F. Cerveau ‘isolé’ et physiologie du sommeil. C R Soc Biol. 1929;102:1235–41.

    Google Scholar 

  5. Goltz F. Der Hund Ohne Grosshirn. Siebente Abhandlung Uber die Verrichttungen des Grosshirns. Arch Ges Physiology. 1892;51:570–614.

    Article  Google Scholar 

  6. Rothmann M Der. Hund Ohne Grosshirn. Neurol Centralbl. 1909;28:1045–6.

    Google Scholar 

  7. Karplus JP, Kreidl A, Uher Totelexstirpationen einer und beider Grosshirnhemisphären an Affen (Macacus rhesus). Arrh f Anat. n. Physiol. 1914;155–212.

  8. White RJ, MacCarty RS. Cranial nerve function following total cerebral hemispherectomy in the monkey (Macaca rhesus). Proc Staff Meet Mayo Clin. 1959;34(1):22–9.

    CAS  PubMed  Google Scholar 

  9. White RJ, Albin MS, Verdura J. Isolation of the monkey brain: in vitro preparation and maintenance. Science. 1963;151:1060–1.

    Article  Google Scholar 

  10. White RJ, Albin MS, Verdura J. Preservation of viability in the isolated monkey brain utilizing a mechanical extracorporeal circulation. Nature. 1964;202:1080–3.

    Article  Google Scholar 

  11. White RJ, Albin MS, Verdura J, Locke GE. Prolonged whole-brain refrigeration with electrical and metabolic recovery. Nature. 1966;209(5030):1320–2.

    Article  CAS  Google Scholar 

  12. White RJ, Brown HW, Albin MS, Verdura J. Rapid selective brain-cooling using head immersion and naso-oral perfusion in dogs. Resuscitation. 1983;10(3):189–91.

    Article  CAS  Google Scholar 

  13. White RJ, Albin MS, Davidson E, Yashon D. Production of lactate and pyruvate by the brain: accumulation of lactate and pyruvate in the recycling circulation of the isolated brain. Surgery. 1968;64(1):60–7.

    CAS  PubMed  Google Scholar 

  14. White RJ, Albin MS, Locke GE, Son D. Brain transplantation: prolonged survival of brain after carotid-jugular interposition. Science. 1965;150:779–81.

    Article  CAS  Google Scholar 

  15. Aminoff MJ. Brown-séquard: an improbably genius who transformed medicine, vol. 313. New York: Oxford University Press; 2011.

    Google Scholar 

  16. Brown-Séquard C. Recherches expérimentales sur les propriétés et les usages du sang rouge et du sang noir. J Physiol (Paris). 1858;1(95–127):353–67.

    Google Scholar 

  17. Yates AJ, Fisk L, Couves CM. Isolation and controlled perfusion of the canine brain. CMA Journal. 1970;102:839–41.

    CAS  Google Scholar 

  18. Lang M, Tsiang J, Moore NZ, Bain MD, Steinmetz MP. A Tribute to Dr Robert. J White Neurosurg. 2019;85(2):E366–73.

    Article  Google Scholar 

Download references

Funding

No extramural funding supported this effort.

Author information

Authors and Affiliations

  1. Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Eelco F. M. Wijdicks MD, PhD

Authors
  1. Eelco F. M. Wijdicks MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

EFMW performed all research relating to this article and is the sole author.

Corresponding author

Correspondence to Eelco F. M. Wijdicks MD, PhD.

Ethics declarations

Conflict of interest

None.

Ethical approval/Informed consent

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the collection “Neurocritical Care Through History”.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wijdicks, E.F.M. Suspended (but No Animation) White’s Isolated Brain Experiments. Neurocrit Care 33, 840–843 (2020). https://doi.org/10.1007/s12028-020-00920-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12028-020-00920-8

Search

Navigation