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Rupture of Cerebral Myxomatous Aneurysm Months After Resection of the Primary Cardiac Tumor

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Abstract

Background

The natural history of cerebral aneurysms derived from metastatic spread of cardiac myxomas is not well known, and their management presents many dilemmas.

Methods

Case report and literature review.

Results

An 18-year-old man presented with an intraparenchymal hemorrhage several months after resection of an atrial myxoma. Angiography showed several myxomatous aneurysms, one of which had bled. The patient had a recurrent hemorrhage before undergoing surgical resection. MRI, angiographic, and pathological data are presented for this rare condition.

Conclusions

Myxomatous aneurysms are important entities for neurointensivists to recognize and can present years after diagnosis. Patients presenting with cerebral infarction or hemorrhage of unknown etiology should undergo cardiac imaging to rule out atrial myxoma, as up to 50% of patients with myxomas present initially with stroke.

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References

  1. Ashalatha R, Moosa A, Gupta AK, Krishna Manohar SR, Sandhyamani S. Cerebral aneurysms in atrial myxoma: a delayed, rare manifestation. Neurol India. 2005;53(2):216–8.

    Article  CAS  PubMed  Google Scholar 

  2. Desousa AL, Muller J, Campbell R, Batnitzky S, Rankin L. Atrial myxoma: a review of the neurological complications, metastases, and recurrences. J Neurol Neurosurg Psychiatry. 1978;41(12):1119–24.

    Article  CAS  PubMed  Google Scholar 

  3. Lee VH, Connolly HM, Brown RD Jr. Central nervous system manifestations of cardiac myxoma. Arch Neurol. 2007;64(8):1115–20.

    Article  PubMed  Google Scholar 

  4. Roeltgen DP, Weimer GR, Patterson LF. Delayed neurologic complications of left atrial myxoma. Neurology. 1981;31(1):8–13.

    CAS  PubMed  Google Scholar 

  5. Stollberger C, Finsterer J. Patients with cardiac myxoma require surveillance for myxoma-related cerebral aneurysms. Eur J Neurol. 2008;15(12):e110–1.

    Article  CAS  PubMed  Google Scholar 

  6. Mantovani G, Bondioni S, Corbetta S, et al. Analysis of GNAS1 and PRKAR1A gene mutations in human cardiac myxomas not associated with multiple endocrine disorders. J Endocrinol Invest. 2009;32(6):501–4.

    CAS  PubMed  Google Scholar 

  7. Ryou KS, Lee SH, Park SH, Park J, Hwang SK, Hamm IS. Multiple fusiform myxomatous cerebral aneurysms in a patient with Carney complex. J Neurosurg. 2008;109(2):318–20.

    Article  PubMed  Google Scholar 

  8. Swartz MF, Lutz CJ, Chandan VS, Landas S, Fink GW. Atrial myxomas: pathologic types, tumor location, and presenting symptoms. J Card Surg. 2006;21(4):435–40.

    Article  PubMed  Google Scholar 

  9. Yu K, Liu Y, Wang H, Hu S, Long C. Epidemiological and pathological characteristics of cardiac tumors: a clinical study of 242 cases. Interact Cardiovasc Thorac Surg. 2007;6(5):636–9.

    Article  PubMed  Google Scholar 

  10. Wein TH, Bornstein NM. Stroke prevention: cardiac and carotid-related stroke. Neurol Clin. 2000;18(2):321–41.

    Article  CAS  PubMed  Google Scholar 

  11. Day AL, Gaposchkin CG, Yu CJ, Rivet DJ, Dacey RG Jr. Spontaneous fusiform middle cerebral artery aneurysms: characteristics and a proposed mechanism of formation. J Neurosurg. 2003;99(2):228–40.

    Article  PubMed  Google Scholar 

  12. Orlandi A, Ciucci A, Ferlosio A, Pellegrino A, Chiariello L, Spagnoli LG. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Am J Pathol. 2005;166(6):1619–28.

    CAS  PubMed  Google Scholar 

  13. Acebo E, Val-Bernal JF, Gomez-Roman JJ, Revuelta JM. Clinicopathologic study and DNA analysis of 37 cardiac myxomas: a 28-year experience. Chest. 2003;123(5):1379–85.

    Article  PubMed  Google Scholar 

  14. Amano J, Kono T, Wada Y, et al. Cardiac myxoma: its origin and tumor characteristics. Ann Thorac Cardiovasc Surg. 2003;9(4):215–21.

    PubMed  Google Scholar 

  15. Koo YH, Kim TG, Kim OJ, Oh SH. Multiple fusiform cerebral aneurysms and highly elevated serum interleukin-6 in cardiac myxoma. J Korean Neurosurg Soc. 2009;45(6):394–6.

    Article  PubMed  Google Scholar 

  16. Yeh HH, Yang CC, Tung WF, Wang HF, Tung JN. Young stroke, cardiac myxoma, and multiple emboli: a case report and literature review. Acta Neurol Taiwan. 2006;15(3):201–5.

    PubMed  Google Scholar 

  17. Jean WC, Walski-Easton SM, Nussbaum ES. Multiple intracranial aneurysms as delayed complications of an atrial myxoma: case report. Neurosurgery. 2001;49(1):200–2. discussion 202–3.

    Article  CAS  PubMed  Google Scholar 

  18. Sabolek M, Bachus-Banaschak K, Bachus R, Arnold G, Storch A. Multiple cerebral aneurysms as delayed complication of left cardiac myxoma: a case report and review. Acta Neurol Scand. 2005;111(6):345–50.

    Article  CAS  PubMed  Google Scholar 

  19. Yilmaz MB, Akin Y, Guray U, Kisacik HL, Korkmaz S. Late recurrence of left atrial myxoma with multiple intracranial aneurysms. Int J Cardiol. 2003;87(2–3):303–5.

    Article  PubMed  Google Scholar 

  20. Nakatomi H, Segawa H, Kurata A, et al. Clinicopathological study of intracranial fusiform and dolichoectatic aneurysms: insight on the mechanism of growth. Stroke. 2000;31(4):896–900.

    CAS  PubMed  Google Scholar 

  21. Dispensa BP, Saloner DA, Acevedo-Bolton G, et al. Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging. J Magn Reson Imaging. 2007;26(1):177–83.

    Article  PubMed  Google Scholar 

  22. Ducruet AF, Hickman ZL, Zacharia BE, et al. Intracranial infectious aneurysms: a comprehensive review. Neurosurg Rev. 2009;33(1):37–6.

    Google Scholar 

  23. Eddleman CS, Surdell D, DiPatri A Jr, Tomita T, Shaibani A. Infectious intracranial aneurysms in the pediatric population: endovascular treatment with Onyx. Childs Nerv Syst. 2008;24(8):909–15.

    Article  PubMed  Google Scholar 

  24. Kannoth S, Thomas SV. Intracranial microbial aneurysm (infectious aneurysm): current options for diagnosis and management. Neurocrit Care. 2009;11(1):120–9.

    Article  PubMed  Google Scholar 

  25. Li Q, Lv F, Li Y, Li K, Luo T, Xie P. Subtraction CT angiography for evaluation of intracranial aneurysms: comparison with conventional CT angiography. Eur Radiol. 2009;19(9):2261–7.

    Article  PubMed  Google Scholar 

  26. Furuya K, Sasaki T, Yoshimoto Y, Okada Y, Fujimaki T, Kirino T. Histologically verified cerebral aneurysm formation secondary to embolism from cardiac myxoma. Case report. J Neurosurg. 1995;83(1):170–3.

    Article  CAS  PubMed  Google Scholar 

  27. Kvitting JP, Engvall J, Broqvist M, et al. Recurrence of myxoma in the left ventricle with concurrent cerebral fusiform aneurysms after previous atrial myxoma surgery. J Thorac Cardiovasc Surg. 2008;135(5):1172–3.

    Article  PubMed  Google Scholar 

  28. Li Q, Shang H, Zhou D, Liu R, He L, Zheng H. Repeated embolism and multiple aneurysms: central nervous system manifestations of cardiac myxoma. Eur J Neurol. 2008;15(12):e112–3.

    Article  CAS  PubMed  Google Scholar 

  29. Rodrigues D, Matthews N, Scoones D, Aziz F, Nath F. Recurrent cerebral metastasis from a cardiac myxoma: case report and review of literature. Br J Neurosurg. 2006;20(5):318–20.

    Article  CAS  PubMed  Google Scholar 

  30. Steinmetz EF, Calanchini PR, Aguilar MJ. Left atrial myxoma as a neurological problem: a case report and review. Stroke. 1973;4(3):451–8.

    CAS  PubMed  Google Scholar 

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Correspondence to Richard A. Bernstein.

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Eddleman, C.S., Gottardi-Littell, N.R., Bendok, B.R. et al. Rupture of Cerebral Myxomatous Aneurysm Months After Resection of the Primary Cardiac Tumor. Neurocrit Care 13, 252–255 (2010). https://doi.org/10.1007/s12028-010-9400-z

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  • DOI: https://doi.org/10.1007/s12028-010-9400-z

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