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The role of TGF-beta signaling in dendritic cell tolerance

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Abstract

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine present in vertebrate and invertebrate organisms that functions in numerous physiological and pathological processes. TGF-β impacts all the cells of the immune system, and of the three known TGF-β isoforms, TGF-β1 is the predominant isoform expressed in immune cells. TGF-β1 is known to play a pivotal role in the function of all immune cells especially in the regulation of T cell development and in the induction of immunological tolerance in dendritic cells (DCs). Based on the importance of DCs in regulation of the innate and adaptive arms of the immune system, in this review we explore the regulatory functions of TGF-β required for establishment and maintenance of DC-mediated immune tolerance.

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Acknowledgements

The authors are indebted to Dr. Ubaldo Soto for his kind help with the artwork material used in this manuscript.

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  1. Department of Earth and Biological Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA

    Grace E. Esebanmen

  2. Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Mortensen Hall, Loma Linda, CA, USA

    Grace E. Esebanmen & William H. R. Langridge

  3. Division of Biochemistry, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA

    William H. R. Langridge

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Esebanmen, G.E., Langridge, W.H.R. The role of TGF-beta signaling in dendritic cell tolerance. Immunol Res 65, 987–994 (2017). https://doi.org/10.1007/s12026-017-8944-9

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