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AID expression during B-cell development: searching for answers

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Abstract

Expression of activation-induced cytidine deaminase (AID) by germinal center (GC) B cells drives the processes of immunoglobulin (Ig) somatic hypermutation (SHM) and class switch recombination (CSR) necessary for the generation of high affinity IgG serum antibody and the memory B-cell compartment. Increasing evidence indicates that AID is also expressed at low levels in developing B cells but to date, this early, developmentally regulated AID expression has no known function. Does the timing and extent of AID expression in developmentally immature, non-GC B cells provide clues to reveal its physiologic role?

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Acknowledgments

Our laboratory has benefitted from the intelligence and diligence of many persons over the years. Among those individuals, we thank Dongmei Liao, Mandy Womble, Yi Li, Yoshihiro Ueda, Lindsay G. Cowell, T. Matt Holl, Derek Cain, and Deborah Feyes for their help with the research topics outlined in this article.

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  1. Department of Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Masayuki Kuraoka & Garnett Kelsoe

  2. Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Laurie McWilliams

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  1. Masayuki Kuraoka
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Correspondence to Garnett Kelsoe.

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Kuraoka, M., McWilliams, L. & Kelsoe, G. AID expression during B-cell development: searching for answers. Immunol Res 49, 3–13 (2011). https://doi.org/10.1007/s12026-010-8185-7

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