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Is parathyroid allotransplantation a viable option in the treatment of permanent hypoparathyroidism? A review of the literature

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Abstract

Background

The standard clinical treatment for hypoparathyroidism, replacement of calcium and vitamin metabolites (calcitriol), has been used for decades; however, evidence points to its inefficiency in acting on the pathophysiology of the disease, which may precipitate or aggravate conditions already related to hypoparathyroidism. Therapies based on recombinant human parathyroid hormone have emerged in recent years but still have low availability due to their high cost. Parathyroid allotransplantation (Pt-a) has been reported as a strategy for treating more severe cases.

Methods

This narrative review highlights relevant aspects of conventional permanent hypoparathyroidism treatment and provides a comprehensive and critical review of the reports of applications of Pt-a, especially those carried out in recent years. Particular focus is placed on the following key points: parathyroid immunogenicity, immunosuppression regimens (short-term or chronic), techniques to reduce the expression of immunogenic molecules, follow-up time, and reductions in calcium and vitamin D supplementation.

Conclusion

Pt-a has been considered a safe and relatively low-cost therapy and is believed to have the potential to cure the disease, in addition to treating symptoms. However, there is considerable heterogeneity in treatment protocols; therefore, more studies are required to improve the standardization of the procedure and thus improve the consistency of outcomes.

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  1. Federal University of Ceará, Fortaleza, Ceará, Brazil

    Daniel Duarte Gadelha, Wellington Alves Filho, Marjorie Azevedo Jales Brandão & Renan Magalhães Montenegro Jr

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All authors contributed to the study’s conception. Material preparation was performed by D.D.G. The first draft of the manuscript was written by D.D.G. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Gadelha, D.D., Filho, W.A., Brandão, M.A.J. et al. Is parathyroid allotransplantation a viable option in the treatment of permanent hypoparathyroidism? A review of the literature. Endocrine 80, 253–265 (2023). https://doi.org/10.1007/s12020-022-03292-5

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