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Risk factors for corticosteroid-induced hyperglycemia requiring insulin therapy in hospitalized patients without diabetes

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All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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References

  1. S. Suh, M.K. Park, Glucocorticoid-induced diabetes mellitus: an important but overlooked problem. Endocrinol. Metab. 32(2), 180–189 (2017). https://doi.org/10.3803/EnM.2017.32.2.180

    Article  CAS  Google Scholar 

  2. G.E. Umpierrez, S.D. Isaacs, N. Bazargan et al. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J. Clin. Endocrinol. Metab. 87(3), 978–982 (2002). https://doi.org/10.1210/jcem.87.3.8341

    Article  CAS  PubMed  Google Scholar 

  3. American Diabetes Association. 15. Diabetes care in the hospital: standards of medical care in diabetes—2019. Diabetes Care. 2019;42(Suppl 1):S173–S181.A.C. Donihi, D. Raval, M. Saul et al.

  4. Prevalence and predictors of corticosteroid-related hyperglycemia in hospitalized patients. Endocr Pract. 12(4), 358–362 (2006). https://doi.org/10.4158/EP.12.4.358.

  5. X.X. Liu, X.M. Zhu, Q. Miao et al. Hyperglycemia induced by glucocorticoids in nondiabetic patients: a meta-analysis. Ann. Nutr. Metab. 65(4), 324–332 (2014). https://doi.org/10.1159/000365892.

    Article  CAS  PubMed  Google Scholar 

  6. J.D. Udoetuk, Y. Dai, G.S. Ying et al. Risk of corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye diseases. Ophthalmology 119(8), 1569–1574 (2012). https://doi.org/10.1016/j.ophtha.2012.01.043.

    Article  PubMed  Google Scholar 

  7. A.C. Fong, N.W. Cheung, The high incidence of steroid-induced hyperglycaemia in hospital. Diabetes Res. Clin. Pract. 99, 277–280 (2013). https://doi.org/10.1016/j.diabres.2012.12.023

    Article  CAS  PubMed  Google Scholar 

  8. S.Y. Kim, C.G. Yoo, C.T. Lee et al. Incidence and risk factors of steroid-induced diabetes in patients with respiratory disease. J. Korean Med. Sci. 26(2), 264 (2011). https://doi.org/10.3346/jkms.2011.26.2.264

    Article  PubMed  PubMed Central  Google Scholar 

  9. P. Darmon, F. Dadoun, S. Boullu-Ciocca et al. Insulin resistance induced by hydrocortisone is increased in patients with abdominal obesity. Am. J. Physiol. Endocrinol. Metab. 291(5), (2006).https://doi.org/10.1152/ajpendo.00654.2005.

  10. J.E. Henriksen, F. Alford, G.M. Ward et al. Risk and mechanism of dexamethasone-induced deterioration of glucose tolerance in non-diabetic first-degree relatives of NIDDM patients. Diabetologia 40(12), 1439–1448 (1997). https://doi.org/10.1007/s001250050847

    Article  CAS  PubMed  Google Scholar 

  11. F. Aberer, J.K. Mader, J. Holzgruber et al. Feasibility and safety of using an automated decision support system for insulin therapy in the treatment of steroid-induced hyperglycemia in patients with acute graft-versus-host disease: A Randomized Trial. J. Diabetes Investig. 10(2), 339–342 (2019). https://doi.org/10.1111/jdi.12919

    Article  CAS  PubMed  Google Scholar 

  12. A. Agudo-Tabuenca, J.A. Gimeno-Orna, D. Saenz-Abad. Assessment of the efficacy and safety of a protocol to manage glucocorticoid-induced hyperglycemia in diabetic patients during hospital stay. Endocrinol. Diabetes Nutr. 66(6), 353–360 (2019). https://doi.org/10.1016/j.endinu.2019.01.008

    Article  Google Scholar 

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Authors and Affiliations

Authors

Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by C.L. and G.S. The manuscript was written by C.L. with input from all authors. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Gretchen Stern.

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Conflict of interest

The authors declare no competing interests.

Ethical approval

This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Human Investigation Committee (IRB) of Partners HealthCare approved this study.

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Li, C., Krause, P. & Stern, G. Risk factors for corticosteroid-induced hyperglycemia requiring insulin therapy in hospitalized patients without diabetes. Endocrine 73, 476–479 (2021). https://doi.org/10.1007/s12020-021-02703-3

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  • DOI: https://doi.org/10.1007/s12020-021-02703-3

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