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Assessment of metabolic control and use of flash glucose monitoring systems in a cohort of pediatric, adolescents, and adults patients with Type 1 diabetes

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Abstract

Purpose

Flash glucose monitoring (FGM) in patients with type 1 diabetes (DM1) provides glucometric data that allow assessing glycemic control beyond HbA1c. The objective of this study was to evaluate metabolic control and use of FGM in a cohort of the pediatric and adult population with DM1.

Material and methods

A cross-sectional study of patients with DM1 and FGM. Data on the use of the system and metabolic control were evaluated, carrying out a comparative study between different age ranges, ≤12 years; 13–19 years, 20–25 years, and ≥26 years.

Results

One hundred and ninety-five patients have included: 35.9% children and adolescents (≤19 years), 42.6% female, 26.2% in treatment with an insulin pump. Mean age was 28.5 ± 15.9 years, mean duration of diabetes 13.7 ± 11.0 years, and mean HbA1c 7.1 ± 0.9% (54 ± 6 mmol/l). Average daily FGM scans were 11.1 ± 6.7. Mean glucose was 162 ± 35 mg/dl, mean standard deviation (SD) 66.1 ± 20.4 mg/dl, mean coefficient of variation 41.4 ± 7.9%, mean time in range (TIR) 58.8 ± 17.0%, mean time above range 33.7 ± 17.6% and mean time below range 7.5 ± 5.8%. The pediatric group showed higher TIR, lower HbA1c, lower glycemic variability, lower mean glucose, and higher use of the device than the adult population. In the entire cohort, the device scans showed a negative quadratic correlation with HbA1c, mean glucose, SD, and age and a positive quadratic correlation with TIR.

Conclusions

Children under 12 years showed the best metabolic control and the most frequent use of the device. Metabolic control deteriorates with age. The greater number of device scans was in correlation with better metabolic control in all age groups.

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Author notes

  1. These authors contributed equally: Mª Pilar Bahíllo-Curieses, Gonzalo Díaz-Soto

Authors and Affiliations

  1. Pediatrics Department. Pediatric Endocrinology Unit, Hospital Clínico Universitario Valladolid, Avenida Ramón y Cajal number 3, 47005, Valladolid, Spain

    Mª Pilar Bahíllo-Curieses, Ana Mª Vidueira-Martínez & Irune Torres-Ballester

  2. Endocrinology and Nutrition Department, Hospital Clínico Universitario Valladolid, Avenida Ramón y Cajal 3, 47005, Valladolid, Spain

    Gonzalo Díaz-Soto, Emilia Gómez-Hoyos & Daniel de Luis-Román

Authors
  1. Mª Pilar Bahíllo-Curieses
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  2. Gonzalo Díaz-Soto
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  3. Ana Mª Vidueira-Martínez
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  4. Irune Torres-Ballester
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  5. Emilia Gómez-Hoyos
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Correspondence to Mª Pilar Bahíllo-Curieses.

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Conflict of interest

The authors hereby confirm that neither the manuscript nor any part of it has been published or is being considered for publication elsewhere. By signing this letter, each of us acknowledges that we participated sufficiently in the work to take public responsibility for its content. Each author listed on the manuscript has seen and approved the submission of this version of the manuscript and takes full responsibility for the manuscript. The authors declare that they do not have any potential conflict of interest (real or perceived) and no sponsors contributed to the study design, collection, and interpretation of data, writing of the report, or in the decision to submit the paper for publication.

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Ethics approval statement was obtained (Protocol number PI-19-1390).

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Bahíllo-Curieses, M.P., Díaz-Soto, G., Vidueira-Martínez, A.M. et al. Assessment of metabolic control and use of flash glucose monitoring systems in a cohort of pediatric, adolescents, and adults patients with Type 1 diabetes. Endocrine 73, 47–51 (2021). https://doi.org/10.1007/s12020-021-02691-4

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  • DOI: https://doi.org/10.1007/s12020-021-02691-4

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