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Long-term remission of disseminated parathyroid cancer following immunotherapy

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Abstract

Purpose

Parathyroid cancer is a rare tumor associated with poor prognosis particularly when disseminated. While chemotherapy and/or radiotherapy are of no clinical value in disseminated disease, immunotherapy should be considered.

Subject and results

A patient with CDC73-associated metastatic parathyroid carcinoma was treated with combined anti-hPTH immunotherapy and surgery.

Conclusions

Following five courses of anti-hPTH immunotherapy and subsequent surgery, a 12-year long remission of disseminated parathyroid cancer is reported. This case further supports the ever-expanding spectrum of cancers that may benefit from immunotherapy.

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Acknowledgements

We thank the members of the NIH Clinical Center for their involvement in treating this patient and the Medical team at the Centro de Tecnologia e Medicina Molecular, Faculdade de Medicina/UFMG, in Belo Horizonte, Brazil.

Funding

This work was partially funded by grant from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq # 405053/2013-4).

Author information

Authors and Affiliations

  1. Department of Surgery, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190, Belo Horizonte, 30130-100, Brazil

    Marta Sarquis, Maria Aparecida C. Bicalho & Luiz De Marco

  2. Section on Genetics and Endocrinology (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, USA

    Stephen J. Marx

  3. Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Liège Université, Liège, Belgium

    Albert Beckers, Adrian F. Daly & Daniela Betea

  4. College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Arthur R. Bradwell

  5. Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

    William F. Simonds

  6. The Suzanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel

    Eitan Friedman

Authors
  1. Marta Sarquis
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  2. Stephen J. Marx
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  3. Albert Beckers
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  4. Arthur R. Bradwell
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  5. William F. Simonds
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  6. Maria Aparecida C. Bicalho
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  7. Adrian F. Daly
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  8. Daniela Betea
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  9. Eitan Friedman
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  10. Luiz De Marco
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Corresponding author

Correspondence to Luiz De Marco.

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Sarquis, M., Marx, S.J., Beckers, A. et al. Long-term remission of disseminated parathyroid cancer following immunotherapy. Endocrine 67, 204–208 (2020). https://doi.org/10.1007/s12020-019-02136-z

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  • DOI: https://doi.org/10.1007/s12020-019-02136-z

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