Skip to main content
SpringerLink
Log in

Pre-training levels of testosterone and sex hormone-binding globulin are not correlated with training adaptations in fat mass and insulin sensitivity in healthy young men

  • Research Letter
  • Published:
Endocrine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. J. Pritchard, J.P. Despres, J. Gagnon, A. Tchernof, A. Nadeau, A. Tremblay, C. Bouchard, Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins. Metabolism 48, 1120–1127 (1999)

    Article  CAS  PubMed  Google Scholar 

  2. A.C. Hackney, Effects of endurance exercise on the reproductive system of men: the “exercise-hypogonadal male condition”. J. Endocrinol. Invest. 31, 932–938 (2008)

    Article  CAS  PubMed  Google Scholar 

  3. J.A. Hounard, C. McCulley, M.H. Shinebarger, N.J. Bruno, Effects of exercise training on plasma androgens in men. Horm. Metab. Res. 26, 297–300 (1994)

    Article  Google Scholar 

  4. V.N. Hawkins, K. Foster-schubert, J. Chubak, B. Sorensen, C.M. Ulrich, F.Z. Stancyzk, S. Plymate, J. Stanford, E. White, J.D. Potter, A. McTiernan, Effect of exercise on serum sex hormones in men: a 12-month randomized clinical trial. Med. Sci. Sports Exerc. 40, 223–233 (2008)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. G.D. Wheeler, M. Singh, W.D. Pierce, W.F. Epling, D.C. Cumming, Endurance training decreases serum testosterone levels in men without change in luteinizing hormone pulsatile release. J. Clin. Endocrinol. Metab. 72, 422–425 (1991)

    Article  CAS  PubMed  Google Scholar 

  6. A. Rinnov, C. Yfanti, S. Nielsen, T. Akerström, L. Peijs, A. Zankari, C.P. Fischer, B.K. Pedersen, Endurance training enhances skeletal muscle interleukin-15 in human male subjects. Endocrine 45, 271–278 (2014)

    Article  CAS  PubMed  Google Scholar 

  7. C. Yfanti, A.R. Nielsen, T. Akerström, S. Nielsen, A. Rose, E.A. Richter, J. Lykkesfeldt, C.P. Fischer, B.K. Pedersen, Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. Am. J. Physiol. Endocrinol. Metab. 300, E761–E770 (2011)

    Article  CAS  PubMed  Google Scholar 

  8. C. Yfanti, T. Akerström, S. Nielsen, A.R. Nielsen, R. Mounier, O.H. Mortensen, J. Lykkesfeldt, A. Rose, C.P. Fischer, B.K. Pedersen, Antioxidant supplementation does not alter endurance training adaptation. Med. Sci. Sports Exerc. 42, 1388–1395 (2010)

    Article  CAS  PubMed  Google Scholar 

  9. S. Nielsen, C. Scheele, C. Yfanti, T. Akerström, A.R. Nielsen, B.K. Pedersen, M.J. Laye, Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle. J. Physiol. 588, 4029–4037 (2010)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. C. Yfanti, C.P. Fischer, S. Nielsen, T. Akerström, A.R. Nielsen, A.S. Veskoukis, D. Kouretas, J. Lykkesfeldt, H. Pilegaard, B.K. Pedersen, Role of vitamin C and E supplementation on IL-6 in response to training. J. Appl. Physiol. 112, 990–1000 (2012)

    Article  CAS  PubMed  Google Scholar 

  11. D.M. Greenfield, S.J. Walters, R.E. Coleman, B.W. Hancock, R. Eastell, H.A. Davies, J.A. Snowden, S.M. Derogatis, S.M. Shalet, R.J. Ross, Prevalence and consequences of androgen deficiency in young male cancer survivors in a controlled cross-sectional study. J. Clin. Endocrinol. Metab. 92, 3476–3482 (2007)

    Article  CAS  PubMed  Google Scholar 

  12. T.L. Nielsen, C. Hagen, K. Wraae, K. Brixen, P.H. Petersen, E. Haug, R. Larsen, M. Andersen, Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. J. Clin. Endocrinol. Metab. 92, 2696–2705 (2007)

    Article  CAS  PubMed  Google Scholar 

  13. A. Tchernof, J.P. Despres, A. Dupont, A. Belanger, A. Nadeau, S. Prud’homme, S. Moorjani, P.J. Lupien, F. Labrie, Relation of steroid hormones to glucose tolerance and plasma insulin levels in men. Importance of visceral adipose tissue. Diabetes Care 18, 292–299 (1995)

    Article  CAS  PubMed  Google Scholar 

  14. M. Grossmann, E.J. Gianatti, J.D. Zajac, Testosterone and type 2 diabetes. Curr. Opin. Endocrinol. Diabetes Obes. 17, 247–256 (2010)

    Article  CAS  PubMed  Google Scholar 

  15. D.E. Laaksonen, L. Niskanen, K. Punnonen, K. Nyyssönen, T.P. Tuomainen, V.P. Valkonen, R. Salonen, J.T. Salonen, Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 27, 1036–1041 (2004)

    Article  CAS  PubMed  Google Scholar 

  16. R. Haring, H. Völzke, S.B. Felix, S. Schipf, M. Dörr, D. Rosskopf, M. Nauck, C. Schöfl, H. Wallaschofski, Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania. Diabetes 58, 2027–2031 (2009)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

Ruth Rousing, Hanne Villumsen and Kirsten Jørgensen are acknowledged for their technical assistance.

Funding

The Centre of Inflammation and Metabolism (CIM) is supported by a grant from the Danish National Research Foundation (DNRF55). The Centre for Physical Activity Research (CFAS) is supported by a grant from Trygfonden. The Copenhagen Muscle Research Centre (CMRC) is supported by a grant from the Capital Region of Denmark.

Author information

Authors and Affiliations

  1. Department of Infectious Disease, Centre of Physical Activity Research, The Centre of Inflammation and Metabolism, Rigshospitalet 7641, Blegdamsvej 9, 2100, Copenhagen, Denmark

    Thine Hvid, Thorbjorn Akerstrom, Søren Nielsen, Christina Yfanti, Birgitte Lindegaard, Bente K. Pedersen & Pernille Hojman

  2. Department of Growth and Reproduction 6 EDMaRC, Faculty of Health and Medical Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    Anders Juul

Authors
  1. Thine Hvid
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thorbjorn Akerstrom
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Søren Nielsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christina Yfanti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anders Juul
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Birgitte Lindegaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bente K. Pedersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Pernille Hojman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pernille Hojman.

Ethics declarations

Conflict of Interest

The authors have no conflict of interest, financial or otherwise, to declare.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hvid, T., Akerstrom, T., Nielsen, S. et al. Pre-training levels of testosterone and sex hormone-binding globulin are not correlated with training adaptations in fat mass and insulin sensitivity in healthy young men. Endocrine 52, 660–663 (2016). https://doi.org/10.1007/s12020-015-0771-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-015-0771-y

Keywords

Search

Navigation