References
J.H. Oppenheimer, H.L. Schwartz, Molecular basis of thyroid hormone-dependent brain development. Endocr. Rev. 18, 462–475 (1997)
J.E. Haddow, G.E. Palomaki, W.C. Allan, J.R. Williams, G.J. Knight, J. Gagnon, C.E. O’Heir, M.L. Mitchell, R.J. Hermos, S.E. Waisbren, J.D. Faix, R.Z. Klein, Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N. Engl. J. Med. 341, 549–555 (1999)
V.J. Pop, E.P. Brouwers, H.L. Vader, T. Vulsma, A.L. van Baar, J.J. de Vijlder, Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin. Endocrinol. 59, 282–288 (2003)
D. Glinoer, The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr. Rev. 18, 404–433 (1997)
S.J. Mandel, P.R. Larsen, E.W. Seely, G.A. Brent, Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N. Engl. J. Med. 323, 91–96 (1990)
A. Stagnaro-Green, M. Abalovich, E. Alexander, F. Azizi, J. Mestman, R. Negro, A. Nixon, E.N. Pearce, O.P. Soldin, S. Sullivan, W. Wiersinga, American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 21, 1081–1125 (2011)
L. De Groot, M. Abalovich, E.K. Alexander, N. Amino, L. Barbour, R.H. Cobin, C.J. Eastman, J.H. Lazarus, D. Luton, S.J. Mandel, J. Mestman, J. Rovet, S. Sullivan, Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 97, 2543–2565 (2012)
S. Downing, L. Halpern, J. Carswell, R.S. Brown, Severe maternal hypothyroidism corrected prior to the third trimester is associated with normal cognitive outcome in the offspring. Thyroid 22, 625–630 (2012)
N. Momotani, S. Iwama, K. Momotani, Neurodevelopment in children born to hypothyroid mothers restored to normal thyroxine (T4) concentration by late pregnancy in Japan: no apparent influence of maternal T4 deficiency. J. Clin. Endocrinol. Metab. 97, 1104–1108 (2012)
M. Rotondi, C. Caccavale, C. Di Serio, A. Del Buono, F. Sorvillo, D. Glinoer, A. Bellastella, C. Carella, Successful outcome of pregnancy in a thyroidectomized-parathyroidectomized young woman affected by severe hypothyroidism. Thyroid 9, 1037–1040 (1999)
B.C.L. Touwen, Examination of the child with minor neurological dysfunction (William International Medical Publications, London, 1979), p. 71
D. Wechsler, The Wechsler Preschool and Primary Scale of Intelligence (Organizzazioni Speciali, Firenze, 1998)
T.M. Achenbach, The Child Behaviour Checklist (University of Vermont, Burlington, 1991)
D. Wechsler, Wechsler Intelligence Scale for Children, 3rd edn. (The Psychological Corporation, San Antonio, 1991)
J. Piaget, Main Trends in Psychology (George Allen & Unwin, London, 1973)
A.W. Siegman, The effect of cultural factors on the relationship between personality, intelligence, and ethnocentric attitudes. J. Consult. Clin. Psychol. 22, 375–377 (1958)
M.M. Bohlken, R.M. Brouwer, R.C. Mandl, N.E. van Haren, R.G. Brans, G.C. van Baal, E.J. de Geus, D.I. Boomsma, R.S. Kahn, H.E. Hulshoff Pol, Genes contributing to subcortical volumes and intellectual ability implicate the thalamus. Hum. Brain Mapp. 35, 2632–2642 (2014)
D. Glinoer, Potential consequences of maternal hypothyroidism on the offspring: evidence and implications. Horm. Res. 55, 109–114 (2001)
M. Rotondi, G. Amato, B. Biondi, G. Mazziotti, A. Del Buono, M.R. Nicchio, S. Balzano, A. Bellastella, D. Glinoer, C. Carella, Parity as a thyroid size-determining factor in areas with moderate iodine deficiency. J. Clin. Endocrinol. Metab. 85, 4534–4537 (2000)
M. Rotondi, G. Mazziotti, F. Sorvillo, M. Piscopo, M. Cioffi, G. Amato, C. Carella, Effects of increased thyroxine dosage pre-conception on thyroid function during early pregnancy. Eur. J. Endocrinol. 151, 695–700 (2004)
K.L. Hynes, P. Otahal, I. Hay, J.R. Burgess, Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort. J. Clin. Endocrinol. Metab. 98, 1954–1962 (2013)
M. Moleti, F. Trimarchi, F. Vermiglio, Thyroid physiology in pregnancy. Endocr. Pract. 21, 1–26 (2014)
S.C. Bath, C.D. Steer, J. Golding, P. Emmett, M.P. Rayman, Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet 382, 331–337 (2013)
M.A. Beydoun, H.A. Beydoun, M.H. Kitner-Triolo, J.S. Kaufman, M.K. Evans, A.B. Zonderman, Thyroid hormones are associated with cognitive function: moderation by sex, race, and depressive symptoms. J. Clin. Endocrinol. Metab. 98, 3470–3481 (2013)
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Pasquali, D., Carotenuto, M., Leporati, P. et al. Maternal hypothyroidism and subsequent neuropsychological outcome of the progeny: a family portrait. Endocrine 50, 797–801 (2015). https://doi.org/10.1007/s12020-015-0564-3
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DOI: https://doi.org/10.1007/s12020-015-0564-3