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Haptoglobin phenotype in women with preeclampsia

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Abstract

In pre-eclampsia, poor placentation causes both oxidative and endoplasmic reticulum stress of the placenta. The anti-oxidative protein Haptoglobin has three phenotypes: 1-1, 1-2, and 2-2. Haptoglobin 1-1 is a more potent antioxidant. Our objective was to determine whether haptoglobin 1-1 was less common in women with preeclampsia which is a disease with an oxidatives-stress component, compared to the healthy population. Haptoglobin phenotype was compared in 240 healthy and 120 preeclamptic gravida in a case–control study. Statistical analysis was performed using Chi square test. The prevalence of haptoglobin 1-1 was 13% among healthy women and 6% among preeclamptic women (P = 0.049). Secondary analysis was also performed. The prevalence of haptoglobin 1-1 is higher in healthy compared to preeclamptic subjects, a finding compatible with a protective role. Haptoglobin 1-1 might have a protective role in preeclampsia. Further work is needed with more Hp 1-1 subjects before we can conclude on the possible use of Haptoglobin phenotype to assess the risk of preeclampsia.

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Acknowledgment

This work was supported in part by Abutbul Family in the memory of Abutbul Daniel

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Bnai-Zion Medical Center, Haifa, Israel

    Rami N. Sammour, Ron Gonen & Gonen Ohel

  2. Ambulatory Nephrology Unit, Rambam Health-Care Campus, Technion-Faculty of Medicine, Haifa, Israel

    Farid M. Nakhoul

  3. Department of Vascular Medicine, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel

    Farid M. Nakhoul, Andrew P. Levy, Rachel Miller-Lotan, Nakhoul Nakhoul & Hoda R. Awad

  4. Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel

    Farid M. Nakhoul, Andrew P. Levy, Ron Gonen & Gonen Ohel

Authors
  1. Rami N. Sammour
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  2. Farid M. Nakhoul
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  3. Andrew P. Levy
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  4. Rachel Miller-Lotan
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  5. Nakhoul Nakhoul
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  6. Hoda R. Awad
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  7. Ron Gonen
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  8. Gonen Ohel
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Correspondence to Farid M. Nakhoul.

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Rami Samour and Nakhoul Farid contribute equally to the manuscript.

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Sammour, R.N., Nakhoul, F.M., Levy, A.P. et al. Haptoglobin phenotype in women with preeclampsia. Endocr 38, 303–308 (2010). https://doi.org/10.1007/s12020-010-9392-7

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  • DOI: https://doi.org/10.1007/s12020-010-9392-7

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