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Integrins in the Regulation of Mesenchymal Stem Cell Differentiation by Mechanical Signals

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Abstract

Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a chemical response. Integrins are involved in the mechanotransduction from inside to outside and from outside to inside, and ultimately affect the fate of MSCs responding to different mechanical signals. Different integrins participate in different signaling pathways to regulate MSCs multi-differentiation. In this review, we summarize the latest advances in the effects of mechanical signals on the differentiation of MSCs, the importance of integrins in mechanotransduction, the relationship between integrin heterodimers and different mechanical signals, and the interaction among mechanical signals. We put forward our views on the prospect and challenges of developing mechanical biology in tissue engineering and regenerative medicine.

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The datasets used and/or analyzed during the cur- rent study are available from the corresponding author on reasonable request.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (Grant No. 31201052). The authors confirm independence from the sponsors; the content of the article has not been influenced by the sponsors.

Funding

This study was funded by the National Natural Science Foundation of China (Grant No. 31201052). The authors confirm independence from the sponsors; the content of the article has not been influenced by the sponsors.

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  1. Lei Wang and Fuwen Zheng are contributed equally to this study.

Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Jilin University First Hospital, Jilin University, 130021, Changchun, People’s Republic of China

    Lei Wang & Jian Suo

  2. Norman Bethune College of Medicine, Jilin University, 130021, Changchun, People’s Republic of China

    Fuwen Zheng, Ruixue Song & Lequan Zhuang

  3. Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, 130021, Changchun, People’s Republic of China

    Ming Yang

  4. The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, 130021, Changchun, People’s Republic of China

    Lisha Li

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Lei Wang, Fuwen Zheng, Ruixue Song, and Lequan Zhuang participated in the writing. Fuwen Zheng and Lequan Zhuang designed and prepared the figures. Fuwen Zheng and Ruixue Song designed and prepared the tables. Fuwen Zheng and Jian Suo was in charge of proofreading manuscripts. Lisha Li, Jian Suo and Ming Yang designed and polished the paper.

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Correspondence to Ming Yang, Jian Suo or Lisha Li.

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Wang, L., Zheng, F., Song, R. et al. Integrins in the Regulation of Mesenchymal Stem Cell Differentiation by Mechanical Signals. Stem Cell Rev and Rep 18, 126–141 (2022). https://doi.org/10.1007/s12015-021-10260-5

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