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Transcriptional Factors of Thermogenic Adipocyte Development and Generation of Brown and Beige Adipocytes From Stem Cells

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Abstract

Brown and beige adipocytes have been widely known for their potential to dissipate excessive energy into heat form, resulting in an alleviation of obesity and other overweight-related conditions. This review highlights the origins, characteristics, and functions of the various kinds of adipocytes, as well as their anatomic distribution inside the human body. This review mainly focuses on various essential transcriptional factors such as PRDM16, FGF21, PPARα, PPARγ and PGC-1α, which exert their effects on the development and activation of thermogenic adipocytes via important pathways such as JAK-STAT, cAMP-PKA and PI3K-AKT signaling pathways. Additionally, this review will underline promising strategies to generate an unexhausted source of thermogenic adipocytes differentiated from human stem cells. These exogenous thermogenic adipocytes offer therapeutic potential for improvement of metabolic disorders via application as single cell or whole tissue transplantation.

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Abbreviations

ADSC:

adipose derived stem cell

ATP:

adenosine triphosphate

BA:

brown adipocytes

BAT:

brown adipose tissue

BMI:

body mass index

BM-MSC:

bone marrow derived mesenchymal stem cell

hESC:

human embryonic stem cell

hiPSC:

human induced pluripotent stem cell

MPC:

mesenchymal progenitor cell

MSC:

mesenchymal stem cell

UCB-MSC:

umbilical cord blood-derived mesenchymal stem cell

WA:

white adipocytes

WAT:

white adipose tissue

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Authors and Affiliations

  1. Stem Cell Institute, University of Science Ho Chi Minh City, Ho Chi Minh City, Viet Nam

    Thi-Tuong Van Nguyen, Vuong Van Vu & Phuc Van Pham

  2. Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam

    Thi-Tuong Van Nguyen, Vuong Van Vu & Phuc Van Pham

  3. Laboratory of Stem Cell Research and Application, University of Science Ho Chi Minh City, Ho Chi Minh City, Viet Nam

    Phuc Van Pham

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  1. Thi-Tuong Van Nguyen
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  2. Vuong Van Vu
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Correspondence to Phuc Van Pham.

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Van Nguyen, TT., Vu, V.V. & Pham, P.V. Transcriptional Factors of Thermogenic Adipocyte Development and Generation of Brown and Beige Adipocytes From Stem Cells. Stem Cell Rev and Rep 16, 876–892 (2020). https://doi.org/10.1007/s12015-020-10013-w

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