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Different Changing Patterns of Three NOS–NO System Activities after Ischemia–Reperfusion in Rabbit with AMI

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Abstract

NOS–NO system activity is closely correlated with ischemia–reperfusion injury (IRI) and NOS subtypes were suggested to play different roles in IRI. In this work, the activity of serum NOS, NO levels, and ischemic necrosis after reperfusion in rabbit with AMI at different time was studied. We also explored the NOS–NO system activity changes and its correlation with myocardial ischemia and necrosis. It shows that after reperfusion in rabbits with AMI, NO–NOS system activities present different changes at each time point due to inactivation of NO and iNOS activation, and different experimental animals, ischemia–reperfusion degree, and length of time will also lead to different research results. Therefore, it is necessary to conduct dynamic observation on animals from different species at multi-temporal point under the state of NOS–NO system activities, and simultaneously detect inflammatory factor, MDA, and SOD indexes. Therefore, it is a must to conduct relevant drug research studies to make NOS–NO system activities maintain the level in favor of ideal myocardial ischemia reperfusion.

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Authors and Affiliations

  1. Department of Cardiology, CangZhou Central Hospital, CangZhou, Hebei, China

    Jun Zhang, Chao Chen, Fengpeng Li, Guangren Gao, Jinguo Fu, Heping Niu, Kai Yu, Lei Wang, Run Guo, Yanfang Wan, Zhanfeng Ma, Qianyu Zhang, Liping Mu, Jing Liu, Jing Yang & Linlin Wang

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  1. Jun Zhang
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  2. Chao Chen
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  3. Fengpeng Li
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  16. Linlin Wang
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Correspondence to Jun Zhang.

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Zhang, J., Chen, C., Li, F. et al. Different Changing Patterns of Three NOS–NO System Activities after Ischemia–Reperfusion in Rabbit with AMI. Cell Biochem Biophys 79, 857–862 (2021). https://doi.org/10.1007/s12013-021-01011-x

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  • DOI: https://doi.org/10.1007/s12013-021-01011-x

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