Abstract
The prevalence of cardiovascular disease (CVD) is increasing dramatically especially in developing countries like India. CVD is a leading cause of morbidity and mortality. There has been a growing awareness of the role of nutrients in the prevention of CVD. One specific recommendation in the battle against CVD is the increased intake of omega-3 fatty acids, which are polyunsaturated fatty acids. Studies have reported inverse associations of CVD with dietary intake of omega-3 fatty acids, suggesting that omega-3 fatty acids supplementation might exert protective effects on CVD. They exert their cardioprotective effect through multiple mechanisms. Omega-3 fatty acid therapy has shown promise as a useful tool in the primary and secondary prevention of CVD. This review briefly summarizes the effects of omega-3 fatty acids in primary and secondary prevention of CVD.
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Defilippis, A. P., Blaha, M. J., & Jacobson, T. A. (2010). Omega-3 fatty acids for cardiovascular disease prevention. Current Treatment Options in Cardiovascular Medicine, 12, 365–380.
Getz, G. S., & Reardon, C. A. (2007). Nutrition and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 2499–2506.
Kris-Etherton, P. M., Hu, F. B., Ros, E., & Sabaté, J. (2008). The role of tree nuts and peanuts in the prevention of coronary heart disease: Multiple potential mechanisms. Journal of Nutrition, 138, 1746S–1751S.
Carrero, J. J., Fonollá, J., Marti, J. L., Jiménez, J., Boza, J. J., & López-Huertas, E. (2007). Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program. Journal of Nutrition, 137, 384–390.
Artham, S. M., Lavie, C. J., Milani, R. V., Anand, R. G., O’Keefe, J. H., & Ventura, H. O. (2008). Fish oil in primary and secondary cardiovascular prevention. Ochsner Journal, 8(2), 49–60.
Lavie, C. J., Milani, R. V., Mehra, M. R., & Ventura, H. O. (2009). Omega-3 polyunsaturated fatty acids and cardiovascular diseases. Journal of the American College of Cardiology, 54, 585–594.
Roth, E. M., & Harris, W. S. (2010). Fish oil for primary and secondary prevention of coronary heart disease. Current Atherosclerosis Reports, 12, 66–72.
Kandasamy, N., Joseph, F., & Goenka, N. (2008). The role of omega-3 fatty acids in cardiovascular disease, hypertriglyceridaemia and diabetes mellitus. The British Journal of Diabetes & Vascular Disease, 8, 121–128.
Kromhout, D., Bosschieter, E. B., & de Lezenne, Coulander C. (1985). The inverse relation between fish consumption and 20-year mortality from coronary heart disease. New England Journal of Medicine, 312, 1205–1209.
Ascherio, A., Rimm, E. B., Stampfer, M. J., Giovannucci, E. L., & Willett, W. C. (1995). Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. New England Journal of Medicine, 332, 977–982.
Morris, M. C., Manson, J. E., Rosner, B., Buring, J. E., Willett, W. C., & Hennekens, C. H. (1995). Fish consumption and cardiovascular disease in the physicians’ health study: A prospective study. American Journal of Epidemiology, 142, 166–175.
Hu, F. B., Bronner, L., Willett, W. C., Rexrode, K. M., Albert, C. M., Hunter, D., et al. (2002). Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA, 287, 1815–1821.
Dolecek, T. A. (1992). Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proceedings of the Society for Experimental Biology and Medicine, 200, 177–182.
Rodriguez, B. L., Sharp, D. S., Abbott, R. D., Burchfiel, C. M., Masaki, K., Chyou, P. H., et al. (1996). Fish intake may limit the increase in risk of coronary heart disease morbidity and mortality among heavy smokers. The Honolulu Heart Program. Circulation, 94, 952–956.
Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., et al. (2007). Japan EPA Lipid Intervention Study (JELIS) Investigators. Effects of eicosapentaenoic acid on major coronary events in hyper-cholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis. Lancet, 369, 1090–1098.
GISSI-Prevention Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico). (1999). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-prevention trial. Lancet, 354, 447–455.
Leaf, A. (2002). On the reanalysis of the GISSI-Prevenzione. Circulation, 105, 1874–1875.
Marchioli, R., Barzi, F., Bomba, E., Chieffo, C., Di Gregorio, D., Di Mascio, R., et al. (2002). GISSI-Prevenzione Investigators. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: Time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation, 105, 1897–1903.
Macchia, A., Levantesi, G., Franzosi, M. G., Geraci, E., Maggioni, A. P., Marfisi, R., et al. (2005). Left ventricular systolic dysfunction, total mortality, and sudden death in patients with myocardial infarction treated with n-3 polyunsaturated fatty acids. European Journal of Heart Failure, 7, 904–909.
Burr, M. L., Fehily, A. M., Gilbert, J. F., Rogers, S., Holliday, R. M., Sweetnam, P. M., et al. (1989). Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and reinfarction trial (DART). Lancet, 2, 757–761.
Patel, J. V., Tracey, I., Hughes, E. A., & Lip, G. Y. (2009). Omega-3 polyunsaturated fatty acids: A necessity for a comprehensive secondary prevention strategy. Vascular Health and Risk Management, 5, 801–810.
Singh, R. B., Niaz, M. A., Sharma, J. P., Kumar, R., Rastogi, V., & Moshiri, M. (1997). Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: The Indian experiment of infarct survival-4. Cardiovascular Drugs and Therapy, 11, 485–491.
de Lorgeril, M., Salen, P., Martin, J. L., Monjaud, I., Delaye, J., & Mamelle, N. (1999). Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study. Circulation, 99, 779–785.
von Schacky, C., Angerer, P., Kothny, W., Theisen, K., & Mudra, H. (1999). The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine, 130, 554–562.
Leaf, A., Albert, C. M., Josephson, M., Steinhaus, D., Kluger, J., Kang, J. X., et al. (2005). Fatty Acid Antiarrhythmia Trial Investigators. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation, 112, 2762–2768.
Anand, R. G., Alkadri, M., Lavie, C. J., & Milani, R. V. (2008). The role of fish oil in arrhythmia prevention. Journal of Cardiopulmonary Rehabilitation and Prevention, 28, 92–98.
Morris, M. C., Sacks, F., & Rosner, B. (1993). Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation, 88, 523–533.
Appel, L. J., Miller, E. R, 3rd, Seidler, A. J., & Whelton, P. K. (1993). Does supplementation of diet with ‘fish oil’ reduce blood pressure? A meta-analysis of controlled clinical trials. Archives of Internal Medicine, 153, 1429–1438.
Ueshima, H., Stamler, J., Elliott, P., Chan, Q., Brown, I. J., Carnethon, M. R., et al. (2007). INTERMAP Research Group. Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. Hypertension, 50, 313–319.
Calò, L., Bianconi, L., Colivicchi, F., Lamberti, F., Loricchio, M. L., de Ruvo, E., et al. (2005). N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: A randomized, controlled trial. Journal of the American College of Cardiology, 45, 1723–1728.
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Yong Cao, Lei Lu, and Jun Liang have contributed equally to this work.
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Cao, Y., Lu, L., Liang, J. et al. Omega-3 Fatty Acids and Primary and Secondary Prevention of Cardiovascular Disease. Cell Biochem Biophys 72, 77–81 (2015). https://doi.org/10.1007/s12013-014-0407-5
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DOI: https://doi.org/10.1007/s12013-014-0407-5