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Omega-3 Fatty Acids and Primary and Secondary Prevention of Cardiovascular Disease

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Abstract

The prevalence of cardiovascular disease (CVD) is increasing dramatically especially in developing countries like India. CVD is a leading cause of morbidity and mortality. There has been a growing awareness of the role of nutrients in the prevention of CVD. One specific recommendation in the battle against CVD is the increased intake of omega-3 fatty acids, which are polyunsaturated fatty acids. Studies have reported inverse associations of CVD with dietary intake of omega-3 fatty acids, suggesting that omega-3 fatty acids supplementation might exert protective effects on CVD. They exert their cardioprotective effect through multiple mechanisms. Omega-3 fatty acid therapy has shown promise as a useful tool in the primary and secondary prevention of CVD. This review briefly summarizes the effects of omega-3 fatty acids in primary and secondary prevention of CVD.

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References

  1. Defilippis, A. P., Blaha, M. J., & Jacobson, T. A. (2010). Omega-3 fatty acids for cardiovascular disease prevention. Current Treatment Options in Cardiovascular Medicine, 12, 365–380.

    Article  PubMed  Google Scholar 

  2. Getz, G. S., & Reardon, C. A. (2007). Nutrition and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 2499–2506.

    Article  CAS  PubMed  Google Scholar 

  3. Kris-Etherton, P. M., Hu, F. B., Ros, E., & Sabaté, J. (2008). The role of tree nuts and peanuts in the prevention of coronary heart disease: Multiple potential mechanisms. Journal of Nutrition, 138, 1746S–1751S.

    CAS  PubMed  Google Scholar 

  4. Carrero, J. J., Fonollá, J., Marti, J. L., Jiménez, J., Boza, J. J., & López-Huertas, E. (2007). Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program. Journal of Nutrition, 137, 384–390.

    CAS  PubMed  Google Scholar 

  5. Artham, S. M., Lavie, C. J., Milani, R. V., Anand, R. G., O’Keefe, J. H., & Ventura, H. O. (2008). Fish oil in primary and secondary cardiovascular prevention. Ochsner Journal, 8(2), 49–60.

    PubMed Central  PubMed  Google Scholar 

  6. Lavie, C. J., Milani, R. V., Mehra, M. R., & Ventura, H. O. (2009). Omega-3 polyunsaturated fatty acids and cardiovascular diseases. Journal of the American College of Cardiology, 54, 585–594.

    Article  CAS  PubMed  Google Scholar 

  7. Roth, E. M., & Harris, W. S. (2010). Fish oil for primary and secondary prevention of coronary heart disease. Current Atherosclerosis Reports, 12, 66–72.

    Article  CAS  PubMed  Google Scholar 

  8. Kandasamy, N., Joseph, F., & Goenka, N. (2008). The role of omega-3 fatty acids in cardiovascular disease, hypertriglyceridaemia and diabetes mellitus. The British Journal of Diabetes & Vascular Disease, 8, 121–128.

    Article  CAS  Google Scholar 

  9. Kromhout, D., Bosschieter, E. B., & de Lezenne, Coulander C. (1985). The inverse relation between fish consumption and 20-year mortality from coronary heart disease. New England Journal of Medicine, 312, 1205–1209.

    Article  CAS  PubMed  Google Scholar 

  10. Ascherio, A., Rimm, E. B., Stampfer, M. J., Giovannucci, E. L., & Willett, W. C. (1995). Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. New England Journal of Medicine, 332, 977–982.

    Article  CAS  PubMed  Google Scholar 

  11. Morris, M. C., Manson, J. E., Rosner, B., Buring, J. E., Willett, W. C., & Hennekens, C. H. (1995). Fish consumption and cardiovascular disease in the physicians’ health study: A prospective study. American Journal of Epidemiology, 142, 166–175.

    CAS  PubMed  Google Scholar 

  12. Hu, F. B., Bronner, L., Willett, W. C., Rexrode, K. M., Albert, C. M., Hunter, D., et al. (2002). Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA, 287, 1815–1821.

    Article  CAS  PubMed  Google Scholar 

  13. Dolecek, T. A. (1992). Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proceedings of the Society for Experimental Biology and Medicine, 200, 177–182.

    Article  CAS  PubMed  Google Scholar 

  14. Rodriguez, B. L., Sharp, D. S., Abbott, R. D., Burchfiel, C. M., Masaki, K., Chyou, P. H., et al. (1996). Fish intake may limit the increase in risk of coronary heart disease morbidity and mortality among heavy smokers. The Honolulu Heart Program. Circulation, 94, 952–956.

    Article  CAS  PubMed  Google Scholar 

  15. Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., et al. (2007). Japan EPA Lipid Intervention Study (JELIS) Investigators. Effects of eicosapentaenoic acid on major coronary events in hyper-cholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis. Lancet, 369, 1090–1098.

    Article  CAS  PubMed  Google Scholar 

  16. GISSI-Prevention Investigators (Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico). (1999). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-prevention trial. Lancet, 354, 447–455.

    Article  Google Scholar 

  17. Leaf, A. (2002). On the reanalysis of the GISSI-Prevenzione. Circulation, 105, 1874–1875.

    Article  PubMed  Google Scholar 

  18. Marchioli, R., Barzi, F., Bomba, E., Chieffo, C., Di Gregorio, D., Di Mascio, R., et al. (2002). GISSI-Prevenzione Investigators. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: Time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation, 105, 1897–1903.

    Article  CAS  PubMed  Google Scholar 

  19. Macchia, A., Levantesi, G., Franzosi, M. G., Geraci, E., Maggioni, A. P., Marfisi, R., et al. (2005). Left ventricular systolic dysfunction, total mortality, and sudden death in patients with myocardial infarction treated with n-3 polyunsaturated fatty acids. European Journal of Heart Failure, 7, 904–909.

    Article  CAS  PubMed  Google Scholar 

  20. Burr, M. L., Fehily, A. M., Gilbert, J. F., Rogers, S., Holliday, R. M., Sweetnam, P. M., et al. (1989). Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and reinfarction trial (DART). Lancet, 2, 757–761.

    Article  CAS  PubMed  Google Scholar 

  21. Patel, J. V., Tracey, I., Hughes, E. A., & Lip, G. Y. (2009). Omega-3 polyunsaturated fatty acids: A necessity for a comprehensive secondary prevention strategy. Vascular Health and Risk Management, 5, 801–810.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Singh, R. B., Niaz, M. A., Sharma, J. P., Kumar, R., Rastogi, V., & Moshiri, M. (1997). Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: The Indian experiment of infarct survival-4. Cardiovascular Drugs and Therapy, 11, 485–491.

    Article  CAS  PubMed  Google Scholar 

  23. de Lorgeril, M., Salen, P., Martin, J. L., Monjaud, I., Delaye, J., & Mamelle, N. (1999). Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study. Circulation, 99, 779–785.

    Article  PubMed  Google Scholar 

  24. von Schacky, C., Angerer, P., Kothny, W., Theisen, K., & Mudra, H. (1999). The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine, 130, 554–562.

    Article  Google Scholar 

  25. Leaf, A., Albert, C. M., Josephson, M., Steinhaus, D., Kluger, J., Kang, J. X., et al. (2005). Fatty Acid Antiarrhythmia Trial Investigators. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation, 112, 2762–2768.

    Article  CAS  PubMed  Google Scholar 

  26. Anand, R. G., Alkadri, M., Lavie, C. J., & Milani, R. V. (2008). The role of fish oil in arrhythmia prevention. Journal of Cardiopulmonary Rehabilitation and Prevention, 28, 92–98.

    Article  PubMed  Google Scholar 

  27. Morris, M. C., Sacks, F., & Rosner, B. (1993). Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation, 88, 523–533.

    Article  CAS  PubMed  Google Scholar 

  28. Appel, L. J., Miller, E. R, 3rd, Seidler, A. J., & Whelton, P. K. (1993). Does supplementation of diet with ‘fish oil’ reduce blood pressure? A meta-analysis of controlled clinical trials. Archives of Internal Medicine, 153, 1429–1438.

    Article  CAS  PubMed  Google Scholar 

  29. Ueshima, H., Stamler, J., Elliott, P., Chan, Q., Brown, I. J., Carnethon, M. R., et al. (2007). INTERMAP Research Group. Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. Hypertension, 50, 313–319.

    Article  CAS  PubMed  Google Scholar 

  30. Calò, L., Bianconi, L., Colivicchi, F., Lamberti, F., Loricchio, M. L., de Ruvo, E., et al. (2005). N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: A randomized, controlled trial. Journal of the American College of Cardiology, 45, 1723–1728.

    Article  PubMed  Google Scholar 

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Correspondence to Peiying Zhang.

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Yong Cao, Lei Lu, and Jun Liang have contributed equally to this work.

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Cao, Y., Lu, L., Liang, J. et al. Omega-3 Fatty Acids and Primary and Secondary Prevention of Cardiovascular Disease. Cell Biochem Biophys 72, 77–81 (2015). https://doi.org/10.1007/s12013-014-0407-5

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  • DOI: https://doi.org/10.1007/s12013-014-0407-5

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