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Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats

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Abstract

Doxorubicin is associated with cardiotoxicity, and physical exercise seeks to minimize the toxic effects of doxorubicin through physiological cardiac remodeling, as well as the reduction of oxidative stress, evidenced by previous studies. This study aimed to analyze whether running training before treatment with doxorubicin influences tolerance to physical exertion and cardiotoxicity. Thirty-nine male Wistar rats, aged 90 days and weighing between 250 and 300 g, were divided into 4 groups: Control (C), Doxorubicin (D), Trained (T), and Trained + Doxorubicin (TD). Animals in groups T and DT were submitted to treadmill running for 3 weeks, 5 times a week at 18 m/min for 20–30 min before treatment with doxorubicin. Animals in groups D and DT received intraperitoneal injections of doxorubicin hydrochloride three times a week for two weeks, reaching a total cumulative dose of 7.50 mg/kg. Our results show an increase in total collagen fibers in the D group (p = 0.01), but no increase in the TD group, in addition to the attenuation of the number of cardiac mast cells in the animals in the TD group (p = 0.05). The animals in the TD group showed maintenance of tolerance to exertion compared to group D. Therefore, running training attenuated the cardiac damage caused by the treatment with doxorubicin, in addition to maintaining the tolerance to exertion in the rats.

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Data Availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

To the Foundation for Research Support in the state of Minas Gerais (FAPEMIG), for the scholarship received PAPG-Health Sciences (MASTER) for 24 months-Identifier: 11415.

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Authors and Affiliations

  1. Experimental Medicine Laboratory, Department of Medicine, Universidade Federal de Uberlândia-UFU, Uberlândia, MG, Brazil

    Talita Cristina Rodrigues Pereira & Eduardo de Sales Cabral

  2. Department of Medicine, Federal University of Catalão- UFCAT, Catalão-Goiás, Brazil

    Thiago Montes Fidale

  3. Experimental Medicine Laboratory, Department of Medicine, Universidade Federal de Uberlândia-UFU, Uberlândia, MG, Brazil

    Lucas Costa Guimarães, Fernanda Rodrigues de Souza & Luiz Duarte de Ulhôa Rocha Júnior

  4. Department of Physiology, Institute of Biomedical Sciences, Universidade Federal de Uberlândia-UFU, Uberlândia, MG, Brazil

    Simone Ramos Deconte

  5. Veterinary Hospital Universidade Federal de Uberlândia, Uberlândia, MG, Brazil

    Gustavo Cavinato Herrera

  6. Veterinary Medicine, Universidade Federal de Uberlândia-UFU, Uberlândia, MG, Brazil

    Antônio Vicente Mundim

  7. Department of Physiology and Pathology, School of Dentistry-FOAr, Paulista State University “Julio de Mesquita Filho”-UNESP, Araraquara, SP, Brazil

    Paulo Ricardo Lopes

  8. Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Luiz Ricardo Goulart Filho, Universidade Federal de Uberlândia-UFU, Prof. Dr, Uberlândia, MG, Brazil

    Alinne Tatiane Faria Silva

  9. Graduate Program in Health Sciences-PPGCS, Faculty of Medicine, Universidade Federal de Uberlândia-UFU, Uberlândia, MG, Brazil

    Elmiro Santos Resende

  10. Uberlândia, Brazil

    Talita Cristina Rodrigues Pereira

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TCRP, ATFS, LCG, TMF, and ESR: Planning of experiments, TCRP and ATFS: Experiments, TCRP, ATFS, ESC, PRL, FRS, and SRD: Data collection, TCRP, ATFS, TMF, SRD, PRL, and LDURJ: Data analysis, SRD, GCH, and AVM: Space supply, reagents, technicians, and laboratory support, TCRP: Manuscript Writing, TCRP, ATFS, LCG, SRD, GCH, AVM, ESC, PRL, FRS, LDURJ, LR, TMF, and ESR: Manuscript edition, ESR: Study supervision. All authors contributed to this article.

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Correspondence to Talita Cristina Rodrigues Pereira.

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Pereira, T.C.R., Fidale, T.M., Guimarães, L.C. et al. Cardioprotective Effects of the 4-Week Aerobic Running Exercises Before Treatment with Doxorubicin in Rats. Cardiovasc Toxicol 23, 265–277 (2023). https://doi.org/10.1007/s12012-023-09798-2

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