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Ameliorating Effect of Sodium Selenite on Developmental and Molecular Response of Bovine Cumulus-Oocyte Complexes Matured in Vitro Under Heat Stress Condition

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Abstract

Selenium (Se), an essential trace element, plays an important role in the antioxidative defense mechanism, and it has been proven to improve fertility and reproductive efficiency in dairy cattle. The present study evaluated the potential protective action of Se supplement of in vitro maturation (IVM) media on the maturation and subsequent development of bovine cumulus-oocyte complexes (COCs) exposed to heat stress (HS). The treatment with Se improved the viability of cumulus cells (CCs) and oocytes (P < 0.05). The proportion of oocytes reached metaphase II (MII) and those arrested at metaphase I (MI) was greater and lower in treatment than control respectively (P < 0.05). Supplementation with Se increased the percentage of cleaved embryos, total blastocysts, and blastocyst/cleavage ratio (P < 0.05). Moreover, the upregulation of CCND1, SEPP1, GPX-4, SOD, CAT, and downregulation of GRP78, CHOP, and BAX in both Se-treated CCs and oocytes were recorded. The upregulation of NRF2 was detected in Se-treated CCs other than in oocytes, which showed upregulation of IGF2R and SOX-2 as the markers of quality as well. Se supplement in IVM media improved the viability, maturation, and the level of transcripts related to antioxidant defense and quality of heat-treated oocytes, which coincided with greater subsequent development outcomes. Se ameliorated the viability of CCs along with upregulation of antioxidative candidate gene expression and downregulation of apoptosis-related ones to support their protective role on restoring the quality of oocytes against compromising effects of HS.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This work was supported by Shahrekord University, Shahrekord, Iran (grant numbers: 0GRD34M40481).

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Authors and Affiliations

  1. Department of Animal Sciences, Faculty of Basic Science, Shahrekord University, Shahrekord, Iran

    Shervin Toosinia & Mehran Arabi

  2. Research Institute of Animal Embryo Technology, Shahrekord University, Shahrekord, Iran

    Najmeh Davoodian & Ali Kadivar

  3. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

    Ali Kadivar

Authors
  1. Shervin Toosinia
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  2. Najmeh Davoodian
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  3. Mehran Arabi
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  4. Ali Kadivar
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Contributions

Najmeh Davoodian, Mehran Arabi, and Ali Kadivar contributed to the studies conception and design. The manuscript writing was conducted by Najmeh Davoodian. Material preparation and data collection were performed by Najmeh Davoodian and Shervin Toosinia. The molecular analysis and statistical analysis were carried out by Ali Kadivar. All the authors read and approved the final manuscript.

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Correspondence to Najmeh Davoodian.

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No approval of research ethics committees was required to accomplish the goals of this study because all the experiments were conducted with materials collected from a local slaughterhouse.

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All the authors contributed to the performance of the study. The final manuscript was read and approved by all the authors.

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Toosinia, S., Davoodian, N., Arabi, M. et al. Ameliorating Effect of Sodium Selenite on Developmental and Molecular Response of Bovine Cumulus-Oocyte Complexes Matured in Vitro Under Heat Stress Condition. Biol Trace Elem Res 202, 161–174 (2024). https://doi.org/10.1007/s12011-023-03678-0

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