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The Impact of Maternal Overweight on Hair Essential Trace Element and Mineral Content in Pregnant Women and Their Children

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Abstract

The aim of the present study was to investigate hair essential trace elements and mineral levels in 105 pregnant normal-weight (control) and 55 overweight and obese women in the third trimester of pregnancy, as well as in their children at the age of 9 months. The hair essential trace elements and mineral levels were assessed using inductively coupled plasma mass-spectrometry. Overweight pregnant women had significantly reduced Cr (− 24%; p = 0.047) and Zn (− 13%; p = 0.008) content, as well as elevated hair Na and K levels as compared to the controls. Children from overweight and obese mothers had lower hair Mo (− 18%; p = 0.017), Se (− 8%; p = 0.043), and V (− 24%; p = 0.028) levels, as well as elevated Sr content (19%; p = 0.025). Correlation analysis revealed a significant relationship between maternal and child hair levels of Co (r = 0.170; p = 0.038), Cu (r = 0.513; p < 0.001), Mn (r = 0.240; p = 0.003), and Na (r = 0.181; p = 0.027) in the whole sample. Pre-pregnancy maternal body mass index (BMI) positively correlated with maternal hair K (r = 0.336; p < 0.001) and Na (r = 0.212; p = 0.008) and negatively correlated with V (r = − 0.204; p = 0.011) and Zn (r = − 0.162; p = 0.045) levels. The results indicate that impaired trace element and mineral metabolism may play a role in the link between maternal obesity, complications of pregnancy and child’s postnatal development. Hypothetically, dietary improvement may be used as a tool to reduce these risks. However, further experimental and clinical studies are required to investigate the relationship between obesity and trace element metabolism in pregnancy.

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Funding

This work was supported by the Tomsk State University Grant (project No. 8.1.11.2018).

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Authors and Affiliations

  1. Yaroslavl State University, Yaroslavl, Russia

    Anatoly V. Skalny & Alexey A. Tinkov

  2. Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

    Anatoly V. Skalny, Alexey A. Tinkov & Margarita G. Skalnaya

  3. IM Sechenov First Moscow State Medical University, Moscow, Russia

    Anatoly V. Skalny, Alexey A. Tinkov & Margarita G. Skalnaya

  4. Laboratory for Cognitive Investigations and Behavioural Genetics, Tomsk State University, Tomsk, Russia

    Tatiana G. Bohan, Marina B. Shabalovskaya, Olga Terekhina, Svetlana B. Leshchinskaia & Yulia Kovas

  5. Research Institute of Obstetrics, Gynecology and Perinatology, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

    Lyubov A. Agarkova

  6. Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, Orenburg, Russia

    Svetlana V. Notova

  7. Orenburg State University, Orenburg, Russia

    Svetlana V. Notova

  8. Goldsmiths, University of London, London, UK

    Yulia Kovas

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  1. Anatoly V. Skalny
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Correspondence to Alexey A. Tinkov.

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The present study was performed in agreement with the principles of the Declaration of Helsinki and its later amendments. The protocol of the study was approved by the Ethics Committee for Interdisciplinary Investigations (Tomsk State University, Russia) (project No. 8.1.11.2018). All women participated in the investigation on a voluntary basis and were informed about the objectives and procedures of the study. The women signed informed consent for their own and their children’s participation. Hair sampling procedures involving children were performed in the presence of one of the parents.

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Skalny, A.V., Tinkov, A.A., Bohan, T.G. et al. The Impact of Maternal Overweight on Hair Essential Trace Element and Mineral Content in Pregnant Women and Their Children. Biol Trace Elem Res 193, 64–72 (2020). https://doi.org/10.1007/s12011-019-01693-8

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