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Salt-Rich Selenium for Prevention and Control Children with Kashin–Beck Disease: a Meta-analysis of Community-Based Trial

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Abstract

Kashin–Beck disease (KBD) in western China is not well controlled. The objective of this study is to evaluate prevention and control children with KBD through a meta-analysis of a community-based trial. Web of knowledge, PubMed, Elsevier, the Chinese National Knowledge Infrastructure (CNKI), VIP and Wanfang data had been electronically searched up to February 2015. Search terms included the trial terms “Salt rich selenium” and “Kashin-Beck disease.” Eligible studies were prospective trials of salt-rich selenium in endemic villages. Data extraction was performed by two authors using predefined data fields that also included quality evaluation. Of 292 potentially relevant articles initially screened, reporting 11 community-based trials with a total enrollment of 2652 participants were included, from five provinces in China. The pooled odds ratios (OR) and 95 % confidence intervals (CI) of primary prevention in healthy children were 0.16 and 0.08∼0.33, respectively. The OR and 95 % CI of clinical improvement in KBD children were 6.57 and 3.33∼12.93, respectively. The OR of repairing rate of metaphysis lesions was 5.53 (95 % CI 2.92∼10.47) based on X-ray film, which was statistically significantly different in favor of salt-rich selenium. The combined standard mean difference (SMD) of selenium content in hair was 2.54 (95 % CI 1.21∼3.87) which was significantly higher in selenium group. Current evidence showed that supplement salt-rich selenium was effective in reducing new incidence in healthy children and clinical improvement including repairing metaphysis lesions instead of repairing distal end of phalanx lesions in KBD children.

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Acknowledgments

We thank the help of Syed Nasir Ali Shah (Xi’an Jiaotong University) in the revision of our English manuscript. We also thank the National Natural Scientific Foundation of China (81472924) who supported our work.

Authors’ Contributions

Yu FF and Han J together contributed to the design of the research. Wang X and Fang H contributed to the search papers and data extraction as described in the methods. Yu FF and Han J carried out the data analysis and preparation of the manuscript. Liu H contributed to the proofreading of the paper. And all authors approved the version to be published.

Conflict of Interest

The authors declare that they have no competing interests.

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    Authors and Affiliations

    1. Institute of Endemic Diseases of School of Public Health, Health Science Center, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xian Jiaotong University, Xi’an, 710061, China

      Fang-fang Yu, Jing Han, Xi Wang, Hua Fang, Huan Liu & Xiong Guo

    2. School of Public Health, Health Science Center of Xi’an Jiaotong University, No.76 Yan Ta West Road, Xi’an, Shannxi, 710061, People’s Republic of China

      Xiong Guo

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    1. Fang-fang Yu
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    4. Hua Fang
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    Correspondence to Xiong Guo.

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    Fang-fang Yu and Jing Han contributed equally to this work and should be considered co-first authors.

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    Yu, Ff., Han, J., Wang, X. et al. Salt-Rich Selenium for Prevention and Control Children with Kashin–Beck Disease: a Meta-analysis of Community-Based Trial. Biol Trace Elem Res 170, 25–32 (2016). https://doi.org/10.1007/s12011-015-0437-x

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