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Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress

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Abstract

In this paper, the preparation, characterization, and ameliorative effect on high-fat high-sucrose diet-induced hyperglycemia, insulin resistance, oxidative stress in mice of novel oxovanadium(IV)/chitosan (OV/CS) nanocomposites were investigated. The nanobiocomposite was produced by chemical reduction by chitosan and L-ascorbic acid using microwave heating, under environment-friendly conditions, using aqueous solutions, and notably, by using both mediators as reducing and stabilizing agents. In addition, OV/CS nanocomposites were characterized by transmission electron microscopy, energy dispersive spectroscopy, particle size, and zeta potential measurements. In vivo experiments were designed to examine whether the OV/CS nanocomposites would provide additional benefits on oxidative stress, hyperglycemia, and insulin resistance in mice with type 2 diabetes. The results rendered insulin resistant by treating with OV/CS nanocomposites alleviate insulin resistance and improve oxidative stress. Such nanocomposite seem to be a valuable therapy to achieve and/or maintain glycemic control and therapeutic agents in the treatment arsenal for insulin resistance and type 2 diabetes.

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Acknowledgments

We gratefully acknowledge the College of Food Science and Engineering, Ocean University of China for the financial support.

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Authors and Affiliations

  1. College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China

    Yanjun Liu, Xu Jie, Yongli Guo, Xin Zhang, Jingfeng Wang & Changhu Xue

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  1. Yanjun Liu
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  2. Xu Jie
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  3. Yongli Guo
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  4. Xin Zhang
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  5. Jingfeng Wang
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  6. Changhu Xue
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Correspondence to Xu Jie or Changhu Xue.

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Liu, Y., Jie, X., Guo, Y. et al. Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress. Biol Trace Elem Res 169, 310–319 (2016). https://doi.org/10.1007/s12011-015-0420-6

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