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Effects of Chromium Methionine Supplementation on Growth Performance, Serum Metabolites, Endocrine Parameters, Antioxidant Status, and Immune Traits in Growing Pigs

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Abstract

The effects of dietary chromium methionine (CrMet) on growth performance, serum metabolites, endocrine parameters, antioxidant status, and immune traits in growing pigs were investigated. A total of 180 crossbred pigs (30.18 ± 0.28 kg initial body mass) were randomly divided into five groups, each group with six pens, six pigs per pen. Pigs were fed on the same basal diet supplemented with 0 (control), 100, 200, 400, and 800 μg/kg Cr from CrMet for 35 days. The results showed that supplemental CrMet did not affect growth performance. Cr at 200–800 μg/kg significantly decreased serum glucose levels (P < 0.05), while other serum metabolites were unaffected by Cr supplementation. Serum growth hormone (GH) levels were significantly decreased by Cr addition (P < 0.05). Furthermore, serum insulin-like growth factor I (IGF-I) levels were linearly decreased with increased Cr dose, and a significant reduction was observed in pigs fed 800 μg/kg Cr diets (P < 0.05). Serum immunoglobulin A, G, and M concentrations were increased linearly with increased Cr dosage, and pigs fed 400 μg/kg Cr had greater serum immunoglobulin M contents (P < 0.05). Cr at 400 μg/kg significantly increased serum superoxide dismutase and total antioxidant capacity activities (T-AOC) (P < 0.05). However, Cr at 800 μg/kg increased serum catalase activities, while decreasing serum T-AOC contents (P < 0.05). Additionally, there was a significant increase in serum malondialdehyde levels for pigs fed 800 μg/kg Cr diets (P < 0.05). These results indicated that dietary supplementation CrMet decreased serum glucose, GH, and IGF-I levels. Besides, supplemental 400 μg/kg Cr as CrMet improved serum antioxidant status and immune responses, but additional 800 μg/kg Cr resulted in lipid peroxidation in growing pigs.

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Acknowledgments

This study was financially supported by the China Ministry of Agriculture. The authors are grateful to the staff of the Ministry of Agriculture Feed Industry Centre for the help in laboratory analysis.

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All authors have read the manuscript, and none have any potential conflict of interests.

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Authors and Affiliations

  1. State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing, 100193, China

    Yao-Yao Tian, Li-Ying Zhang, Bing Dong, Jun Cao, Jian-Xiang Xue & Li-Min Gong

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  1. Yao-Yao Tian
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  2. Li-Ying Zhang
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Tian, YY., Zhang, LY., Dong, B. et al. Effects of Chromium Methionine Supplementation on Growth Performance, Serum Metabolites, Endocrine Parameters, Antioxidant Status, and Immune Traits in Growing Pigs. Biol Trace Elem Res 162, 134–141 (2014). https://doi.org/10.1007/s12011-014-0147-9

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