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Protective Effect of Zinc on Cyclophosphamide-Induced Hematoxicity and Urotoxicity

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An Erratum to this article was published on 09 January 2009

An Erratum to this article was published on 09 January 2009

Abstract

Cyclophosphamide (CP) is widely used for the treatment of neoplastic diseases; however, its toxicity causes dose-limiting side effects. Zinc (Zn) is an essential trace element and has important biological functions that control many cell processes including DNA synthesis, normal growth, reproduction, fetal development, bone formation, and wound healing. Therefore, the toxicity of CP and the possible protective effect of Zn on blood cells, bone marrow, and bladder of rat were investigated in this study. Intraperitoneal administration of 50, 100, or 150 mg/kg CP for 3 days caused, in a dose-dependent manner, reductions in the number of leukocytes, thrombocytes, and bone marrow nucleated cells and a serious urotoxicity. To explore whether CP-induced damages could be prevented by Zn, other groups of rats were pretreated with 4 or 8 mg/kg ZnCl2 intraperitoneally for 3 days then challenged with respective doses of CP plus ZnCl2 on day 4 for three more days. The results indicated that treatment of rats with Zn could dose-dependently alleviate CP-induced toxicities on blood cells, bone marrow cells, and urinary bladder. We suggest that Zn could be a potentially effective drug in the prevention of CP-related hematoxicity and urotoxicity.

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Authors and Affiliations

  1. Department of Biology, Faculty of Medicine, Faculty of Art and Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey

    Adnan Ayhanci

  2. Department of Physiology, Faculty of Art and Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey

    Ruhi Uyar & Selda Kabadere

  3. Department of Histology, Faculty of Art and Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey

    Erinc Aral

  4. Department of Molecular Biology and Genetics, Faculty of Science, Izmir Institute of Technology, 35430, Urla, Izmir, Turkey

    Sila Appak

Authors
  1. Adnan Ayhanci
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  2. Ruhi Uyar
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  3. Erinc Aral
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  4. Selda Kabadere
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  5. Sila Appak
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Corresponding author

Correspondence to Sila Appak.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s12011-008-8292-7

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Ayhanci, A., Uyar, R., Aral, E. et al. Protective Effect of Zinc on Cyclophosphamide-Induced Hematoxicity and Urotoxicity. Biol Trace Elem Res 126, 186–193 (2008). https://doi.org/10.1007/s12011-008-8189-5

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  • DOI: https://doi.org/10.1007/s12011-008-8189-5

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