Abstract
Purpose of Review
We summarize the history of the clinical high-risk stage of psychosis (CHR), current research on this stage and recent critiques of the field, and evaluate current CHR guidelines and frameworks.
Recent Findings
Following its identification and characterization, CHR services have successfully been developed in North America, Europe, Australia and elsewhere. As reflected in guidelines, these services and their orientation largely emerged as an outgrowth of the framework pioneered by early intervention services for first-episode psychosis. We critically discuss what is known so far about the subjective experience of the CHR syndrome, the meaning of this “unofficial” diagnosis as well as what is known and unknown about the service-related needs.
Summary
While a range of outstanding questions remain in the field, there is a particular need for patient-oriented work and to investigate the service-related needs of young people at CHR.
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References
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Fusar-Poli P, Borgwardt S, Bechdolf A, Addington J, Riecher-Rössler A, Schultze-Lutter F, et al. The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry. 2013;70(1):107–20.
Srihari VH, Shah J, Keshavan MS. Is early intervention for psychosis feasible and effective? Psychiatr Clin North Am. 2012;35(3):613–31. https://doi.org/10.1016/j.psc.2012.06.004.
Birchwood M, Todd P, Jackson C. Early intervention in psychosis: the critical period hypothesis. Br J Psychiatry. 1998;172(S33):53–9.
Kotlicka-Antczak M, Podgorski M, Oliver D, Maric NP, Valmaggia L, Fusar-Poli P. Worldwide implementation of clinical services for the prevention of psychosis: the IEPA early intervention in mental health survey. Early Interv Psychiatry. 2020;14:741–50. https://doi.org/10.1111/eip.12950.
Meares A. The diagnosis of prepsychotic schizophrenia. Lancet. 1959;273(7063):55–8.
Huber G, Gross G. The concept of basic symptoms in schizophrenic and schizoaffective psychoses. Recenti Prog Med. 1989;80(12):646–52.
Schultze-Lutter F. Subjective symptoms of schizophrenia in research and the clinic: the basic symptom concept. Schizophr Bull. 2009;35(1):5–8.
Häfner H, Riecher-Rössler A, Hambrecht M, Maurer K, Meissner S, Schmidtke A, et al. IRAOS: an instrument for the assessment of onset and early course of schizophrenia. Schizophr Res. 1992;6(3):209–23.
Yung AR, McGorry PD, McFarlane CA, Patton GC. The PACE Clinic: development of a clinical service for young people at high risk of psychosis. Australas Psychiatry. 1995;3(5):345–9.
Yung AR, McGorry PD. The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophr Bull. 1996;22(2):353–70.
Yung AR, Yuen HP, McGorry PD, Phillips LJ, Kelly D, Dell'Olio M, et al. Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States. Aust N Z J Psychiatry. 2005;39(11–12):964–71.
Addington J, Cadenhead KS, Cannon TD, Cornblatt B, McGlashan TH, Perkins DO, et al. North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research. Schizophr Bull. 2007;33(3):665–72.
Miller TJ, McGlashan TH, Rosen JL, Somjee L, Markovich PJ, Stein K, et al. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. Am J Psychiatry. 2002;159(5):863–5. https://doi.org/10.1176/appi.ajp.159.5.863.
Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A. Monitoring and care of young people at incipient risk of psychosis. Focus. 2004;22(1):283–174.
Yung AR, Phillips LJ, Yuen HP, Francey SM, McFarlane CA, Hallgren M, et al. Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophr Res. 2003;60(1):21–32.
Fusar-Poli P, Bonoldi I, Yung AR, Borgwardt S, Kempton MJ, Valmaggia L, et al. Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry. 2012;69(3):220–9.
Michel C, Ruhrmann S, Schimmelmann BG, Klosterkötter J, Schultze-Lutter F. Course of clinical high-risk states for psychosis beyond conversion. Eur Arch Psychiatry Clin Neurosci. 2018;268(1):39–48.
Fusar-Poli P, Rutigliano G, Stahl D, Davies C, De Micheli A, Ramella-Cravaro V, et al. Long-term validity of the At Risk Mental State (ARMS) for predicting psychotic and non-psychotic mental disorders. Eur Psychiatry. 2017;42:49–54.
Fusar-Poli P, Cappucciati M, De Micheli A, Rutigliano G, Bonoldi I, Tognin S, et al. Diagnostic and prognostic significance of brief limited intermittent psychotic symptoms (BLIPS) in individuals at ultra high risk. Schizophr Bull. 2016;43(1):48–56.
Fusar-Poli P, Cappucciati M, Rutigliano G, Lee T, Beverly Q, Bonoldi I, et al. Towards a standard psychometric diagnostic interview for subjects at ultra high risk of psychosis: CAARMS versus SIPS. Psychiatry J. 2016;2016:1–11.
van Os J, Guloksuz S. A critique of the “ultra-high risk” and “transition” paradigm. World Psychiatry. 2017;16(2):200–6.
Shah JL, Crawford A, Mustafa SS, Iyer SN, Joober R, Malla AK. Is the clinical high-risk state a valid concept? Retrospective examination in a first-episode psychosis sample. Psychiatr Serv. 2017;68(10):1046–52.
Addington J, Cornblatt BA, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, et al. At clinical high risk for psychosis: outcome for nonconverters. Am J Psychiatr. 2011;168(8):800–5.
Pruessner M, Iyer SN, Faridi K, Joober R, Malla AK. Stress and protective factors in individuals at ultra-high risk for psychosis, first episode psychosis and healthy controls. Schizophr Res. 2011;129(1):29–35.
McGorry PD. The next stage for diagnosis: validity through utility. World Psychiatry. 2013;12(3):213–5. https://doi.org/10.1002/wps.20080.
Fusar-Poli P, Byrne M, Badger S, Valmaggia L, McGuire P. Outreach and Support in South London (OASIS), 2001–2011: ten years of early diagnosis and treatment for young individuals at high clinical risk for psychosis. Eur Psychiatry. 2013;28(5):315–26.
Pruessner M, Faridi K, Shah JL, Rabinovitch M, Iyer SN, Abadi S, et al. The Clinic for Assessment of Youth at Risk (CAYR): 10 years of service delivery and research targeting the prevention of psychosis in Montreal, Canada. Early Interv Psychiatry. 2015;11(2). https://doi.org/10.1111/eip.12300.
Focus on Youth Psychosis Prevention (FYPP) Clinic. The Centre for Addiction and Mental Health. https://www.camh.ca/en/your-care/programs-and-services/focus-on-youth-psychosis-prevention-clinic-fypp. Accessed 6 June 2020.
Addington J, Epstein I, Reynolds A, Furimsky I, Rudy L, Mancini B, et al. Early detection of psychosis: finding those at clinical high risk. Early Interv Psychiatry. 2008;2(3):147–53.
Addington J, Liu L, Buchy L, Cadenhead KS, Cannon TD, Cornblatt BA, et al. North American Prodrome Longitudinal Study (NAPLS 2): the prodromal symptoms. J Nerv Ment Dis. 2015;203(5):328–35.
McIlwaine SV, Jordan G, Pruessner M, Malla A, Faridi K, Iyer SN, et al. Does an integrated outreach intervention targeting multiple stages of early psychosis improve the identification of individuals at clinical high risk? Early Interv Psychiatry. 2018;13:989–92. https://doi.org/10.1111/eip.12750.
Perez J, Jin H, Russo DA, Stochl J, Painter M, Shelley G, et al. Clinical effectiveness and cost-effectiveness of tailored intensive liaison between primary and secondary care to identify individuals at risk of a first psychotic illness (the LEGs study): a cluster-randomised controlled trial. Lancet Psychiatry. 2015;2(11):984–93.
Addington J, Addington D, Abidi S, Raedler T, Remington G. Canadian treatment guidelines for individuals at clinical high risk of psychosis. Can J Psychiatr. 2017;62(9):656–61.
Thompson E, Millman ZB, Okuzawa N, Mittal V, DeVylder J, Skadberg T, et al. Evidence-based early interventions for individuals at clinical high risk for psychosis: a review of treatment components. J Nerv Ment Dis. 2015;203(5):342–51.
Schmidt SJ, Schultze-Lutter F, Schimmelmann BG, Maric NP, Salokangas RK, Riecher-Rossler A, et al. EPA guidance on the early intervention in clinical high risk states of psychoses. Eur Psychiatry. 2015;30(3):388–404. https://doi.org/10.1016/j.eurpsy.2015.01.013.
Petros N, Mechelli A, Fusar-Poli P, Vieira S, Rowland E, McGuire P. Towards a framework for good outcome in people at clinical high risk for psychosis: a Delphi consensus study. Schizophr Res. 2019;208:209–16.
Petros N, Cullen AE, Vieira S, Rowland E, King G, Leung WS, et al. Examining service-user perspectives for the development of a good outcome checklist for individuals at clinical high risk for psychosis. Early Interv Psychiatry. 2020. https://doi.org/10.1111/eip.12991.
Hardy KV, Dickson JM, Morrison AP. Journey into and through an early detection of psychosis service: the subjective experience of persons at risk of developing psychosis. Early Interv Psychiatry. 2009;3(1):52–7.
Gronholm PC, Thornicroft G, Laurens KR, Evans-Lacko S. Conditional disclosure on pathways to care: coping preferences of young people at risk of psychosis. Qual Health Res. 2017;27(12):1842–55.
• Ben-David S, Cole A, Brucato G, Girgis RR, Munson MR. Mental health service use decision-making among young adults at clinical high risk for developing psychosis. Early intervention in psychiatry. 2018;13(5):1050–5. https://doi.org/10.1111/eip.12725. A qualitative study exploring service use of young people at CHR using the unified theory of behaviour framework.
• Yung AR, Wood SJ, Malla A, Nelson B, McGorry P, Shah J. The reality of at risk mental state services: a response to recent criticisms. Psychol Med. 2019:1–7. https://doi.org/10.1017/S003329171900299X. The commentary provides a general overview of recent criticisms regarding the CHR state and its associated services. It comments on stigma associated with CHR services, duration of untreated psychosis, predictive validity of CHR criteria as well as the effectiveness and timing of CHR services.
Fusar-Poli P, Nelson B, Valmaggia L, Yung AR, McGuire PK. Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis. Schizophr Bull. 2012;40(1):120–31.
Falkenberg I, Valmaggia L, Byrnes M, Frascarelli M, Jones C, Rocchetti M, et al. Why are help-seeking subjects at ultra-high risk for psychosis help-seeking? Psychiatry Res. 2015;228(3):808–15.
Brummitt K, Addington J. Treatment possibilities for individuals at clinical high risk of psychosis. Early Interv Psychiatry. 2013;7(2):155–61.
Stowkowy J, Colijn MA, Addington J. Pathways to care for those at clinical high risk of developing psychosis. Early Interv Psychiatry. 2013;7(1):80–3.
• Allan S, Hodgekins J, Beazley P, Oduola S. Pathways to care in at-risk mental states: a systematic review. Early Interv Psychiatry. 2020:1–12. https://doi.org/10.1111/eip.13053. This systematic review summarizes what we currently know regarding pathways to care for individuals at CHR specifically. It describes key pathway agents, number of help-seeking contacts, duration of untreated illness as well as barriers and facilitators influencing pathways to care.
Wiltink S, Velthorst E, Nelson B, McGorry PM, Yung AR. Declining transition rates to psychosis: the contribution of potential changes in referral pathways to an ultra–high-risk service. Early Interv Psychiatry. 2015;9(3):200–6.
MacDonald K, Fainman-Adelman N, Anderson KK, Iyer SN. Pathways to mental health services for young people: a systematic review. Soc Psychiatry Psychiatr Epidemiol. 2018;53(10):1005–38. https://doi.org/10.1007/s00127-018-1578-y.
Shin YM, Jung HY, Kim SW, Lee SH, Shin SE, Park JI, et al. A descriptive study of pathways to care of high risk for psychosis adolescents in Korea. Early Interv Psychiatry. 2010;4(2):119–23.
• Ben-David S, Cole AR, Brucato G, Girgis R, Munson MR. A conceptual model of mental health service utilization among young adults at clinical high-risk for developing psychosis. Psychiatr Rehabil J. 2019;42(1):17. This qualitative study uses a grounded theory approach to develop a conceptual model of help-seeking for young people at CHR. In particular, it highlights the role of contextual, individual, and environmental factors in help-seeking.
Rapado-Castro M, McGorry PD, Yung A, Calvo A, Nelson B. Sources of clinical distress in young people at ultra high risk of psychosis. Schizophr Res. 2015;165(1):15–21.
Ben-David S, Birnbaum ML, Eilenberg ME, DeVylder JE, Gill KE, Schienle J, et al. The subjective experience of youths at clinically high risk of psychosis: a qualitative study. Psychiatr Serv. 2014;65(12):1499–501.
Welsh P, Tiffin PA. Observations of a small sample of adolescents experiencing an at-risk mental state (ARMS) for psychosis. Schizophr Bull. 2011;38(2):215–8.
Reilly T, Mechelli A, McGuire P, Fusar-Poli P, Uhlhaas PJ. E-clinical high risk for psychosis: viewpoint on potential of digital innovations for preventive psychiatry. JMIR Ment Health. 2019;6(10):e14581.
McGorry PD, Nelson B, Wood SJ, Shah JL, Malla A, Yung A. Transcending false dichotomies and diagnostic silos to reduce disease burden in mental disorders. Soc Psychiatry Psychiatr Epidemiol. 2020;55:1098–1103. https://doi.org/10.1007/s00127-020-01913-w.
Shah JL. Bringing clinical staging to youth mental health: from concept to operationalization (and back again). JAMA Psychiatry. 2019;76(11):1121–3.
Acknowledgements
S.V.M. has received funds to support her graduate studies from the Fonds de recherche du Québec-Santé (doctoral training award). J.L.S. has received clinician-scientist career funding from the Fonds de recherche du Québec-Santé.
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McIlwaine, S.V., Shah, J. Mental Health Services Research Targeting the Clinical High-Risk State for Psychosis: Lessons, Future Directions and Integration with Patient Perspectives. Curr Psychiatry Rep 23, 11 (2021). https://doi.org/10.1007/s11920-021-01224-0
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DOI: https://doi.org/10.1007/s11920-021-01224-0