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Recent Advancements in Treating Sleep Disorders in Co-Occurring PTSD

  • Anxiety Disorders (A Pelissolo, Section Editor)
  • Published:
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Abstract

Purpose of Review

Comorbidity of posttraumatic stress disorder (PTSD) and insomnia, nightmares, and obstructive sleep apnea (OSA) is high. We review recent research on psychotherapeutic and pharmacological interventions for sleep disorders in PTSD.

Recent Findings

PTSD treatments decrease PTSD severity and nightmare frequency, but do not resolve OSA or insomnia. Research on whether insomnia hinders PTSD treatment shows mixed results; untreated OSA does interfere with PTSD treatment. Cognitive behavioral therapy for insomnia is the recommended treatment for insomnia; however, optimal ordering with PTSD treatment is unclear. PTSD treatment may be most useful for PTSD-related nightmares. CPAP therapy is recommended for OSA but adherence can be low.

Summary

Targeted treatment of sleep disorders in the context of PTSD offers a unique and underutilized opportunity to advance clinical care and research. Research is needed to create screening protocols, determine optimal order of treatment, and elucidate mechanisms between sleep and PTSD treatments.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Ohayon MM, Shapiro CM. Sleep disturbances and psychiatric disorders associated with posttraumatic stress disorder in the general population. Compr Psychiatry. 2000;41(6):469–78.

    Article  PubMed  CAS  Google Scholar 

  2. Plumb TR, Peachey JT, Zelman DC. Sleep disturbance is common among servicemembers and veterans of Operations Enduring Freedom and Iraqi Freedom. Psychol Serv. 2014;11(2):209–19.

    Article  PubMed  Google Scholar 

  3. Jenkins MM, Colvonen PJ, Norman SB, Afari N, Allard CB, Drummond SP. Prevalence and mental health correlates of insomnia in first-encounter veterans with and without military sexual trauma. Sleep. 2015;38(10):1547–54.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Neylan TC, Marmar CR, Metzler TJ, Weiss DS, Zatzick DF, Delucchi KL, et al. Sleep disturbances in the Vietnam generation: findings from a nationally representative sample of male Vietnam veterans. Sleep. 1998;155(7):929–33.

    CAS  Google Scholar 

  5. Krakow B, Melendrez D, Johnston L, Warner TD, Clark JO, Pacheco M, et al. Sleep-disordered breathing, psychiatric distress, and quality of life impairment in sexual assault survivors. J Nerv Ment Dis. 2002;190(7):442–52.

    Article  PubMed  Google Scholar 

  6. •• Colvonen PJ, Masino T, Drummond SP, Myers US, Angkaw AC, Norman SB. Obstructive sleep apnea and posttraumatic stress disorder among OEF/OIF/OND veterans. J Clin Sleep Med. 2015;11(5):513–8. This study found high rates of OSA in younger, lower BMI veterans with PTSD suggesting the classic signs of OSA may not fit for OEF/OIF/OND veterans.

    PubMed  PubMed Central  Google Scholar 

  7. Nadorff MR, Nazem S, Fiske A. Insomnia symptoms, nightmares, and suicidal ideation in a college student sample. Sleep. 2011;34(1):93–8.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Baran B, Pace-Schott EF, Ericson C, Spencer RM. Processing of emotional reactivity and emotional memory over sleep. J Neurosci. 2012;32(3):1035–42.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Seelig AD, Jacobson IG, Smith B, Hooper TI, Boyko EJ, et al. Sleep patterns before, during, and after deployment to Iraq and Afghanistan. DTIC Document, 2010.

  10. Sharon A, Levav I, Brodsky J, Shemesh AA, Kohn R. Psychiatric disorders and other health dimensions among holocaust survivors 6 decades later. Br J Psychiatry. 2009;195(4):331–5.

    Article  PubMed  Google Scholar 

  11. Noll JG, Trickett PK, Susman EJ, Putnam FW. Sleep disturbances and childhood sexual abuse. J Pediatr Psychol. 2005;31(5):469–80.

    Article  PubMed  Google Scholar 

  12. Brown TH, Mellman TA, Alfano CA, Weems CF. Sleep fears, sleep disturbance, and PTSD symptoms in minority youth exposed to hurricane Katrina. J Trauma Stress. 2011;24(5):575–80.

    Article  PubMed  Google Scholar 

  13. MC USNR RNM, Volkert SL. Insomnia is the most commonly reported symptom and predicts other symptoms of post-traumatic stress disorder in US service members returning from military deployments. Mil Med. 2010;175(10):759.

    Article  Google Scholar 

  14. Wallace D, Shafazand S, Ramos A, Carvalho D, Gardener H, Lorenzo D, et al. Insomnia characteristics and clinical correlates in operation enduring freedom/operation Iraqi freedom veterans with post-traumatic stress disorder and mild traumatic brain injury: an exploratory study. Sleep Med. 2011;12(9):850–9.

    Article  PubMed  CAS  Google Scholar 

  15. Levin R, Nielsen TA. Disturbed dreaming, posttraumatic stress disorder, and affect distress: a review and neurocognitive model. Psychol Bull. 2007;133(3):482–528.

    Article  PubMed  Google Scholar 

  16. Hasler BP, Germain A. Correlates and treatments of nightmares in adults. Sleep medicine clinics. 2009;4(4):507–17.

    Article  PubMed  PubMed Central  Google Scholar 

  17. • Creamer JL, Brock MS, Matsangas P, Motamedi V, Mysliwiec V. Nightmares in United States military personnel with sleep disturbances. J Clin Sleep Med. 2018;14(03):419–26. This study suggests that rates of nightmares were high in active duty personnel, but were rarely the reason for seeking sleep evaluations.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Schwab R, Goldberg A, Pack A. Sleep apnea syndromes. Fishman’s pulmonary diseases and disorders, vol. 1617. New York: McGraw-Hill Book Company; 1998. p. 37.

    Google Scholar 

  19. Krakow B, Melendrez D, Warner TD, Clark JO, Sisley BN, Dorin R, et al. Signs and symptoms of sleep-disordered breathing in trauma survivors: a matched comparison with classic sleep apnea patients. J Nerv Ment Dis. 2006;194(6):433–9.

    Article  PubMed  Google Scholar 

  20. Kinoshita LM, Yesavage JA, Noda A, Jo B, Hernandez B, Taylor J, et al. Modeling the effects of obstructive sleep apnea and hypertension in Vietnam veterans with PTSD. Sleep Breath. 2012;16(4):1201–9.

    Article  PubMed  Google Scholar 

  21. Liempt S, Westenberg HM, Arends J, Vermetten E. Obstructive sleep apnea in combat-related posttraumatic stress disorder: a controlled polysomnography study. Eur J Psychotraumatol. 2011;2(1):8451.

    Article  Google Scholar 

  22. • Gupta MA, Simpson FC. Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med. 2015;11(2):165–75. This study examined the prevalence and treatment of OSA in psychiatric populations, including PTSD; they found increased prevlence of OSA in those with PTSD compared to those without.

    PubMed  PubMed Central  Google Scholar 

  23. •• Zhang Y, Weed JG, Ren R, Tang X, Zhang W. Prevalence of obstructive sleep apnea in patients with posttraumatic stress disorder and its impact on adherence to continuous positive airway pressure therapy: a meta-analysis. Sleep Med. 2017;36:125–32. A meta-analysis to detect the pooled prevalence of OSA in PTSD and its impact on adherence to continuous positive airway pressure (CPAP) therapy.

    Article  PubMed  Google Scholar 

  24. Sharafkhaneh A, Giray N, Richardson P, Young T, Hirshkowitz M. Association of psychiatric disorders and sleep apnea in a large cohort. Sleep. 2005;28(11):1405–11.

    Article  PubMed  Google Scholar 

  25. Williams SG, Collen J, Orr N, Holley AB, Lettieri CJ. Sleep disorders in combat-related PTSD. Sleep and Breathing. 2015;19(1):175–82.

    Article  PubMed  Google Scholar 

  26. • Rezaeitalab F, Mokhber N, Ravanshad Y, Saberi S, Rezaeetalab F. Different polysomnographic patterns in military veterans with obstructive sleep apnea in those with and without post-traumatic stress disorder. Sleep and Breathing. 2018:1–6. In veterans with OSA, the authors compare sleep architecture between those with and without PTSD.

  27. • Germain A, McKeon AB, Campbell RL. Sleep in PTSD: conceptual model and novel directions in brain-based research and interventions. Current opinion in psychology. 2017;14:84–9. This paper underscores sleep as a comorbid, rather than secondary, condition to PTSD. They review the temporal relationship and neurobilogical correlates of the two disorders.

    Article  PubMed  Google Scholar 

  28. Spoormaker VI, Montgomery P. Disturbed sleep in post-traumatic stress disorder: secondary symptom or core feature? Sleep Med Rev. 2008;12(3):169–84.

    Article  PubMed  Google Scholar 

  29. Bryant RA, Creamer M, O'Donnell M, Silove D, McFarlane AC. Sleep disturbance immediately prior to trauma predicts subsequent psychiatric disorder. Sleep. 2010;33(1):69–74.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Germain A, Buysse DJ, Nofzinger E. Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses. Sleep Med Rev. 2008;12(3):185–95.

    Article  PubMed  Google Scholar 

  31. Bonn-Miller MO, Babson KA, Vujanovic AA, Feldner MT. Sleep problems and PTSD symptoms interact to predict marijuana use coping motives: a preliminary investigation. Journal of Dual Diagnosis. 2010;6(2):111–22.

    Article  Google Scholar 

  32. Gehrman P, Seelig AD, Jacobson IG, Boyko EJ, Hooper TI, Gackstetter GD, et al. Predeployment sleep duration and insomnia symptoms as risk factors for new-onset mental health disorders following military deployment. Sleep. 2013;36(7):1009–18.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Wright KM, Britt TW, Bliese PD, Adler AB, Picchioni D, Moore D. Insomnia as predictor versus outcome of PTSD and depression among Iraq combat veterans. J Clin Psychol. 2011;67(12):1240–58.

    Article  PubMed  Google Scholar 

  34. Peterson AL, Goodie JL, Satterfield WA, Brim WL. Sleep disturbance during military deployment. Mil Med. 2008;173(3):230–5.

    Article  PubMed  Google Scholar 

  35. Perlis ML, Giles DE, Mendelson WB, Bootzin RR, Wyatt JK. Psychophysiological insomnia: the behavioural model and a neurocognitive perspective. J Sleep Res. 1997;6(3):179–88.

    Article  PubMed  CAS  Google Scholar 

  36. Bootzin RR, Epstein D, Wood JM. Stimulus control instructions. Case studies in insomnia: Springer; 1991. p. 19–28.

  37. Sjöström N, Hetta J, Waern M. Persistent nightmares are associated with repeat suicide attempt. Psychiatry Res. 2009;170(2):208–11.

    Article  PubMed  Google Scholar 

  38. Bernert RA, Joiner TE Jr, Cukrowicz KC, Schmidt NB, Krakow B. Suicidality and sleep disturbances. Sleep. 2005;28(9):1135–41.

    Article  PubMed  Google Scholar 

  39. Van Liempt S, Vermetten E, Geuze E, Westenberg H. Pharmacotherapeutic treatment of nightmares and insomnia in posttraumatic stress disorder. Ann N Y Acad Sci. 2006;1071(1):502–7.

    Article  PubMed  CAS  Google Scholar 

  40. Kobayashi I, Sledjeski EM, Spoonster E, Fallon WF, Delahanty DL. Effects of early nightmares on the development of sleep disturbances in motor vehicle accident victims. J Trauma Stress. 2008;21(6):548–55.

    Article  PubMed  Google Scholar 

  41. Pietrzak RH, Goldstein RB, Southwick SM, Grant BF. Physical health conditions associated with posttraumatic stress disorder in US older adults: results from wave 2 of the National Epidemiologic Survey on alcohol and related conditions. J Am Geriatr Soc. 2012;60(2):296–303.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003;290(14):1906–14.

    Article  PubMed  CAS  Google Scholar 

  43. Sledjeski EM, Speisman B, Dierker LC. Does number of lifetime traumas explain the relationship between PTSD and chronic medical conditions? Answers from the National Comorbidity Survey-Replication (NCS-R). J Behav Med. 2008;31(4):341–9.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Krakow BJ, Ulibarri VA, Moore BA, McIver ND. Posttraumatic stress disorder and sleep-disordered breathing: a review of comorbidity research. Sleep Med Rev. 2015;24:37–45.

    Article  PubMed  Google Scholar 

  45. •• Jaoude P, Vermont LN, Porhomayon J, El-Solh AA. Sleep-disordered breathing in patients with post-traumatic stress disorder. Ann Am Thorac Soc. 2015;12(2):259–68. The article is a thorough review of the literature on the relationship between SDB and PTSD; they propose pathways and mechanisms between the two disorders.

    Article  PubMed  Google Scholar 

  46. De Kloet C, Vermetten E, Geuze E, Lentjes E, Heijnen C, Stalla G, et al. Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder. Prog Brain Res. 2007;167:287–91.

    Article  CAS  Google Scholar 

  47. Kim E, Grover LM, Bertolotti D, Green TL. Growth hormone rescues hippocampal synaptic function after sleep deprivation. Am J Phys Regul Integr Comp Phys. 2010;298(6):R1588–R96.

    CAS  Google Scholar 

  48. Spoormaker VI, Schröter MS, Andrade KC, Dresler M, Kiem SA, Goya-Maldonado R, et al. Effects of rapid eye movement sleep deprivation on fear extinction recall and prediction error signaling. Hum Brain Mapp. 2012;33(10):2362–76.

    Article  PubMed  Google Scholar 

  49. Arnetz BB, Templin T, Saudi W, Jamil H. Obstructive sleep apnea, posttraumatic stress disorder, and health in immigrants. Psychosom Med. 2012;74(8):824–31.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Krakow B, Melendrez D, Ferreira E, Clark J, Warner TD, Sisley B, et al. Prevalence of insomnia symptoms in patients with sleep-disordered breathing. Chest. 2001;120(6):1923–9.

    Article  PubMed  CAS  Google Scholar 

  51. Krakow B, Melendrez D, Pedersen B, Johnston L, Hollifield M, Germain A, et al. Complex insomnia: insomnia and sleep-disordered breathing in a consecutive series of crime victims with nightmares and PTSD. Biol Psychiatry. 2001;49(11):948–53.

    Article  PubMed  CAS  Google Scholar 

  52. • Brock MS, Mysliwiec V. Comorbid insomnia and sleep apnea: a prevalent but overlooked disorder. Sleep Breath. 2018;22:1–3. A letter to the editor which suggests that OSA is often overlooked and may contribute to detrimental outcomes. They make treatment recommendations to include OSA screening and CPAP therapy.

    Article  PubMed  Google Scholar 

  53. Gupta MA, Knapp K. Cardiovascular and psychiatric morbidity in obstructive sleep apnea (OSA) with insomnia (sleep apnea plus) versus obstructive sleep apnea without insomnia: a case–control study from a nationally representative US sample. PLoS One. 2014;9(3):e90021.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  54. • El-Solh AA, Adamo D, Kufel T. Comorbid insomnia and sleep apnea in veterans with post-traumatic stress disorder. Sleep Breath. 2018:1–9. This study found that veterans with PTSD, insomnia, and OSA had worse quality of life, sleep, and depression than veterans with PTSD and OSA only.

  55. Weathers FW, Blake DD, Schnurr PP, Kaloupek DG, Marx BP, Keane TM. The clinician-administered PTSD scale for DSM-5 (CAPS-5). Interview available from the National Center for PTSD at www.ptsd.va.gov. 2013.

  56. Weathers FW, Litz BT, Keane TM, Palmieri PA, Marx BP, Schnurr PP. The PTSD checklist for DSM-5 (PCL-5). www.ptsd.va.gov. 2013.

  57. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213.

    Article  PubMed  CAS  Google Scholar 

  58. Bastien CH, Vallières A, Morin CM. Validation of the insomnia severity index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297–307.

    Article  PubMed  Google Scholar 

  59. Straus LD, Drummond S, Nappi CM, Jenkins MM, Norman SB. Sleep variability in military-related PTSD: a comparison to primary insomnia and healthy controls. J Trauma Stress. 2015;28(1):8–16.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Krakow B. Nightmare complaints in treatment-seeking patients in clinical sleep medicine settings: diagnostic and treatment implications. Sleep. 2006;29(10):1313–9.

    Article  PubMed  Google Scholar 

  61. Gehrman P. CBT for insomnia in veterans with PTSD. Sleep Med. 2015;16:S9–S10.

    Article  Google Scholar 

  62. Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, et al. STOP Questionnaire: a tool to screen patients for obstructive sleep apnea. Anesthesiology. 2008;108(5):812–21.

    Article  PubMed  Google Scholar 

  63. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131(7):485–91.

    Article  PubMed  CAS  Google Scholar 

  64. Germain A, Hall M, Katherine Shear M, Nofzinger EA, Buysse DJ. Ecological study of sleep disruption in PTSD. Ann N Y Acad Sci. 2006;1071(1):438–41.

    Article  PubMed  Google Scholar 

  65. guideline VDcp. VA/DOD clinical practice guideline for management of post-traumatic stress. Washington (DC): Department of Veterans Affairs, Department of Defense; 2010. 2016.

  66. •• Guina J, Rossetter SR, DeRHODES BJ, Nahhas RW, Welton RS. Benzodiazepines for PTSD: a systematic review and meta-analysis. J Psychiatr Pract. 2015;21(4):281–303. This meta-analysis suggests benzodiazepines have modest, beneficial effects on PTSD and sleep but risks associated with their use outweigh potential short-term benefits.

    Article  PubMed  Google Scholar 

  67. Luyster FS, Buysse DJ, Strollo PJ Jr. Comorbid insomnia and obstructive sleep apnea: challenges for clinical practice and research. J Clin Sleep Med. 2010;6(2):196–204.

    PubMed  PubMed Central  Google Scholar 

  68. Sloan EP, Shapiro CM. Hypnotics should never be used in patients with sleep apnea. J Psychosom Res. 1993;37:59–65.

    Article  Google Scholar 

  69. Huedo-Medina TB, Kirsch I, Middlemass J, Klonizakis M, Siriwardena AN. Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration. BMJ. 2012;345:e8343.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  70. Pollack MH, Hoge EA, Worthington JJ, Moshier SJ, Wechsler RS, Brandes M, et al. Eszopiclone for the treatment of posttraumatic stress disorder and associated insomnia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2011;72(7):892–7.

    Article  PubMed  CAS  Google Scholar 

  71. Zhang XJ, Li QY, Wang Y, Xu HJ, Lin YN. The effect of non-benzodiazepine hypnotics on sleep quality and severity in patients with OSA: a meta-analysis. Sleep Breath. 2014;18(4):781–9.

    Article  PubMed  Google Scholar 

  72. Warner M, Dorn M, Peabody C. Survey on the usefulness of trazodone in patients with PTSD with insomnia or nightmares. Pharmacopsychiatry. 2001;34(04):128–31.

    Article  PubMed  CAS  Google Scholar 

  73. Mendelson WB. A review of the evidence for the efficacy and safety of trazodone in insomnia. J Clin Psychiatry. 2005;66(4):469–76.

    Article  PubMed  CAS  Google Scholar 

  74. Friedmann PD, Rose JS, Swift R, Stout RL, Millman RP, Stein MD. Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial. Alcohol Clin Exp Res. 2008;32(9):1652–60.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  75. Smales ET, Edwards BA, Deyoung PN, McSharry DG, Wellman A, Velasquez A, et al. Trazodone effects on obstructive sleep apnea and non-REM arousal threshold. Ann Am Thorac Soc. 2015;12(5):758–64.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Roth AJ, McCall WV, Liguori A. Cognitive, psychomotor and polysomnographic effects of trazodone in primary insomniacs. J Sleep Res. 2011;20(4):552–8.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Stein MB, Kline NA, Matloff JL. Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study. Am J Psychiatr. 2002;159(10):1777–9.

    Article  PubMed  Google Scholar 

  78. Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, et al. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs Cooperative Study #504. J Clin Psychiatry. 2016;77(4):483–91.

    Article  PubMed  Google Scholar 

  79. • Villarreal G, Hamner MB, Cañive JM, Robert S, Calais LA, Durklaski V, et al. Efficacy of quetiapine monotherapy in posttraumatic stress disorder: a randomized, placebo-controlled trial. Am J Psychiatr. 2016;173(12):1205–12. This study found that quetiapine monotherapy improved PTSD symptoms overall, but had modest and transient effects on insomnia.

    Article  PubMed  Google Scholar 

  80. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353(12):1209–23.

    Article  PubMed  CAS  Google Scholar 

  81. Green B. Prazosin in the treatment of PTSD. J Psychiatr Pract. 2014;20(4):253–9.

    Article  PubMed  Google Scholar 

  82. • George KC, Kebejian L, Ruth LJ, Miller CW, Himelhoch S. Meta-analysis of the efficacy and safety of prazosin versus placebo for the treatment of nightmares and sleep disturbances in adults with posttraumatic stress disorder. J Trauma Dissociation. 2016;17(4):494–510. This meta-analysis identified prazosin as more effective than placebo in improving nightmares, sleep quality, and illness severity.

    Article  PubMed  Google Scholar 

  83. •• Khachatryan D, Groll D, Booij L, Sepehry AA, Schütz CG. Prazosin for treating sleep disturbances in adults with posttraumatic stress disorder: a systematic review and meta-analysis of randomized controlled trials. Gen Hosp Psychiatry. 2016;39:46–52. This meta-anlysis examined 6 RTCs and found that prazosin impoved sleep quality and reduced overall PTSD symptoms.

    Article  PubMed  Google Scholar 

  84. • Raskind MA, Peskind ER, Chow B, Harris C, Davis-Karim A, Holmes HA, et al. Trial of prazosin for post-traumatic stress disorder in military veterans. N Engl J Med. 2018;378(6):507–17. This study found that prazosin showed no differences when compared to placebo in alleviate distressing dreams, improve sleep quality, or show improvement in any other PTSD symptom cluster.

    Article  PubMed  CAS  Google Scholar 

  85. Tamanna S, Parker JD, Lyons J, Ullah M. The effect of continuous positive air pressure (CPAP) on nightmares in patients with posttraumatic stress disorder (PTSD) and obstructive sleep apnea (OSA). J Clin Sleep Med. 2014;10(6):631–6.

    PubMed  PubMed Central  Google Scholar 

  86. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of sleep medicine clinical practice guideline. J Clin Sleep Med. 2017;13(2):307–49.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Ahmadpanah M, Sabzeiee P, Hosseini SM, Torabian S, Haghighi M, Jahangard L, et al. Comparing the effect of prazosin and hydroxyzine on sleep quality in patients suffering from posttraumatic stress disorder. Neuropsychobiology. 2014;69(4):235–42.

    Article  PubMed  CAS  Google Scholar 

  88. Galovski TE, Monson C, Bruce SE, Resick PA. Does cognitive–behavioral therapy for PTSD improve perceived health and sleep impairment? J Trauma Stress. 2009;22(3):197–204.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Gutner CA, Casement MD, Gilbert KS, Resick PA. Change in sleep symptoms across cognitive processing therapy and prolonged exposure: a longitudinal perspective. Behav Res Ther. 2013;51(12):817–22.

    Article  PubMed  Google Scholar 

  90. Belleville G, Guay S, Marchand A. Persistence of sleep disturbances following cognitive-behavior therapy for posttraumatic stress disorder. J Psychosom Res. 2011;70(4):318–27.

    Article  PubMed  Google Scholar 

  91. •• Pruiksma KE, Taylor DJ, Wachen JS, Mintz J, Young-McCaughan S, Peterson AL, Yarvis JS, Borah EV, Dondanville KA, Litz BT, Hembree EA, Resick PA Residual sleep disturbances following PTSD treatment in active duty military personnel. Psychol Trauma. 2016;8(6):697–701. This study found that insomnia is the most frequently reported symptom before and after PTSD treatment in active duty military participants, and did not decrease following PTSD treatment.

  92. Zayfert C, DeViva JC. Residual insomnia following cognitive behavioral therapy for PTSD. J Trauma Stress. 2004;17(1):69–73.

    Article  PubMed  Google Scholar 

  93. • Levrier K, Leathead C, Bourdon D-É, Lacerte S, Marchand A, Belleville G. The impact of cognitive-behavioral therapies for nightmares and prazosin on the reduction of post-traumatic nightmares, sleep, and PTSD symptoms: a systematic review and meta-analysis of randomized and non-randomized studies. A multidimensional approach to post-traumatic stress disorder-from theory to practice: InTech; 2016. This meta-analysis found that both prazosin and CBTs for nightmares reduced PTSD, sleep symptoms, and nightmares; however, prazosin had larger effects sizes on reducing nightmares than CBTs for nightmare treatments.

  94. •• Brownlow JA, McLean CP, Gehrman PR, Harb GC, Ross RJ, Foa EB. Influence of sleep disturbance on global functioning after posttraumatic stress disorder treatment. J Trauma Stress. 2016;29(6):515–21. This study found that PE was effective in reducing PTSD and insomnia symptoms, but that higher insomnia and nightmares predicted poorer global functioning post-treatment. This suggests that addressing insomnia and nightmares may extend beyond just PTSD/insomnia symptoms.

    Article  PubMed  Google Scholar 

  95. • López CM, Lancaster CL, Gros DF, Acierno R. Residual sleep problems predict reduced response to prolonged exposure among veterans with PTSD. J Psychopathol Behav Assess. 2017;39(4):755–63. This study found that greater residual insomnia symptoms following PE were predictive of smaller improvement in PTSD symptoms.

    Article  PubMed  PubMed Central  Google Scholar 

  96. •• Lommen MJ, Grey N, Clark DM, Wild J, Stott R, Ehlers A. Sleep and treatment outcome in posttraumatic stress disorder: results from an effectiveness study. Depress Anxiety. 2016;33(7):575–83. This study found that patients with worse comorbid depression and poorer sleep showed less decrease in PTSD symptoms with CT-PTSD treatment.

    Article  PubMed  Google Scholar 

  97. •• Woodward E, Hackmann A, Wild J, Grey N, Clark DM, Ehlers A. Effects of psychotherapies for posttraumatic stress disorder on sleep disturbances: results from a randomized clinical trial. Behav Res Ther. 2017;97:75–85. This study found that CT-PTSD, compared to waitlist, improved self-reported sleep duration and nightmares. Additionally, baseline sleep did not interfere with PTSD treatment outcomes.

    Article  PubMed  PubMed Central  Google Scholar 

  98. •• Sexton MB, Avallone KM, Smith ER, Porter KE, Ashrafioun L, Arnedt JT, et al. Sleep disturbances as predictors of prolonged exposure therapy effectiveness among veterans with PTSD. Psychiatry Res. 2017;256:118–23. This study found that higher PSQI scores were related to higher baseline PCL scores. PSQI scores were not associated with reduced effectiveness of PE treatment or slope of PTSD symptom changes.

    Article  PubMed  Google Scholar 

  99. •• Mesa F, Dickstein BD, Wooten VD, Chard KM. Response to cognitive processing therapy in veterans with and without obstructive sleep apnea. J Trauma Stress. 2017;30(6):646–55. This study found that veterans with OSA reported greater PTSD severity over the course of CPT than veterans without OSA. Veterans treated with CPAP reported greater PTSD treatment improvements than veterans with untreated OSA.

    Article  PubMed  Google Scholar 

  100. •• Reist C, Gory A, Hollifield M. Sleep-disordered breathing impact on efficacy of prolonged exposure therapy for posttraumatic stress disorder. J Trauma Stress. 2017;30(2):186–9. This study found that untreated sleep disordered breathing reduced the efficacy of PE.

    Article  PubMed  Google Scholar 

  101. Qaseem A, Kansagara D, Forciea MA, Cooke M, Denberg TD. Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2016;165(2):125–33.

    Article  PubMed  Google Scholar 

  102. Bastien CH, Morin CM, Ouellet M-C, Blais FC, Bouchard S. Cognitive-behavioral therapy for insomnia: comparison of individual therapy, group therapy, and telephone consultations. J Consult Clin Psychol. 2004;72(4):653–9.

    Article  PubMed  Google Scholar 

  103. Edinger JD, Means MK. Cognitive–behavioral therapy for primary insomnia. Clin Psychol Rev. 2005;25(5):539–58.

    Article  PubMed  Google Scholar 

  104. Omvik S, Pallesen S, Havik OE, Kvale G, Nordhus IH. Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA. 2006;295(24):2851–8.

    Article  PubMed  Google Scholar 

  105. Morin CM, Hauri PJ, Espie CA, Spielman AJ, Buysse DJ, Bootzin RR. Nonpharmacologic treatment of chronic insomnia. An American Academy of sleep medicine review. Sleep. 1999;22(8):1134–56.

    Article  PubMed  CAS  Google Scholar 

  106. •• Wu JQ, Appleman ER, Salazar RD, Ong JC. Cognitive behavioral therapy for insomnia comorbid with psychiatric and medical conditions: a meta-analysis. JAMA Intern Med. 2015;175(9):1461–72. This meta-analysis found that CBT-I is efficacious for improving comorbid insomnia in patients with PTSD.

    Article  PubMed  Google Scholar 

  107. •• Ho FY-Y, Chan CS, Tang KN-S. Cognitive-behavioral therapy for sleep disturbances in treating posttraumatic stress disorder symptoms: a meta-analysis of randomized controlled trials. Clin Psychol Rev. 2016;43:90–102. This meta-analysis found that CBT-I is efficacious and feasible in treating PTSD symptoms.

    Article  PubMed  Google Scholar 

  108. Talbot LS, Maguen S, Metzler TJ, Schmitz M, McCaslin SE, Richards A, et al. Cognitive behavioral therapy for insomnia in posttraumatic stress disorder: a randomized controlled trial. Sleep. 2014;37(2):327–41.

    Article  PubMed  PubMed Central  Google Scholar 

  109. Ulmer CS, Edinger JD, Calhoun PS. A multi-component cognitive-behavioral intervention for sleep disturbance in veterans with PTSD: a pilot study. J Clin Sleep Med. 2011;7(1):57–68.

    PubMed  PubMed Central  Google Scholar 

  110. Margolies SO, Rybarczyk B, Vrana SR, Leszczyszyn DJ, Lynch J. Efficacy of a cognitive-behavioral treatment for insomnia and nightmares in Afghanistan and Iraq veterans with PTSD. J Clin Psychol. 2013;69(10):1026–42.

    Article  PubMed  Google Scholar 

  111. Rosenbaum S, Sherrington C, Tiedemann A. Exercise augmentation compared with usual care for post-traumatic stress disorder: a randomized controlled trial. Acta Psychiatr Scand. 2015;131(5):350–9.

    Article  PubMed  CAS  Google Scholar 

  112. Nakamura Y, Lipschitz DL, Landward R, Kuhn R, West G. Two sessions of sleep-focused mind–body bridging improve self-reported symptoms of sleep and PTSD in veterans: a pilot randomized controlled trial. J Psychosom Res. 2011;70(4):335–45.

    Article  PubMed  Google Scholar 

  113. King HC, Spence DL, Hickey AH, Sargent P, Elesh R, Connelly CD. Auricular acupuncture for sleep disturbance in veterans with post-traumatic stress disorder: a feasibility study. Mil Med. 2015;180(5):582–90.

    Article  PubMed  Google Scholar 

  114. • Galovski TE, Harik JM, Blain LM, Elwood L, Gloth C, Fletcher TD. Augmenting cognitive processing therapy to improve sleep impairment in PTSD: a randomized controlled trial. J Consult Clin Psychol. 2016;84(2):167–77. This study found that hypnosis plus CPT outperformed CPT alone on PTSD symptoms only in deperessed patients.

    Article  PubMed  Google Scholar 

  115. Abramowitz EG, Barak Y, Ben-Avi I, Knobler HY. Hypnotherapy in the treatment of chronic combat-related PTSD patients suffering from insomnia: a randomized, zolpidem-controlled clinical trial. Int J Clin Exp Hypn. 2008;56(3):270–80.

    Article  PubMed  Google Scholar 

  116. Casement MD, Swanson LM. A meta-analysis of imagery rehearsal for post-trauma nightmares: effects on nightmare frequency, sleep quality, and posttraumatic stress. Clin Psychol Rev. 2012;32(6):566–74.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Hansen K, Höfling V, Kröner-Borowik T, Stangier U, Steil R. Efficacy of psychological interventions aiming to reduce chronic nightmares: a meta-analysis. Clin Psychol Rev. 2013;33(1):146–55.

    Article  PubMed  Google Scholar 

  118. Thünker J, Pietrowsky R. Effectiveness of a manualized imagery rehearsal therapy for patients suffering from nightmare disorders with and without a comorbidity of depression or PTSD. Behav Res Ther. 2012;50(9):558–64.

    Article  PubMed  Google Scholar 

  119. Cook JM, Harb GC, Gehrman PR, Cary MS, Gamble GM, Forbes D, et al. Imagery rehearsal for posttraumatic nightmares: a randomized controlled trial. J Trauma Stress. 2010;23(5):553–63.

    Article  PubMed  Google Scholar 

  120. Germain A, Richardson R, Moul DE, Mammen O, Haas G, Forman SD, et al. Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US military veterans. J Psychosom Res. 2012;72(2):89–96.

    Article  PubMed  Google Scholar 

  121. •• Seda G, Sanchez-Ortuno MM, Welsh CH, Halbower AC, Edinger JD. Comparative meta-analysis of prazosin and imagery rehearsal therapy for nightmare frequency, sleep quality, and posttraumatic stress. J Clin Sleep Med. 2015;11(1):11–22. This meta-analysis suggests that adding CBT to IRT enchances treatment outcomes related to sleep quality and PTSD.

    PubMed  PubMed Central  Google Scholar 

  122. Scott JC, Harb G, Brownlow JA, Greene J, Gur RC, Ross RJ. Verbal memory functioning moderates psychotherapy treatment response for PTSD-related nightmares. Behav Res Ther. 2017;91:24–32.

    Article  PubMed  Google Scholar 

  123. •• Ross R, Harb G. CBT for nightmares in OEF/OIF veterans. Philadelphia Research and Education Foundation Philadelphia United States, 2015. Compared CBT-I alone to IR + CBT-I and found no differences between the two groups on nightmare frequency or distress, suggesting CBT-I alone may be effective in reducing nightmares.

  124. Rybarczyk B, Stepanski E, Fogg L, Lopez M, Barry P, Davis A. A placebo-controlled test of cognitive-behavioral therapy for comorbid insomnia in older adults. J Consult Clin Psychol. 2005;73(6):1164–74.

    Article  PubMed  Google Scholar 

  125. Davis JL, Wright DC. Randomized clinical trial for treatment of chronic nightmares in trauma-exposed adults. J Trauma Stress. 2007;20(2):123–33.

    Article  PubMed  Google Scholar 

  126. Davis JL, Rhudy JL, Pruiksma KE, Byrd P, Williams AE, McCabe KM, et al. Physiological predictors of response to exposure, relaxation, and rescripting therapy for chronic nightmares in a randomized clinical trial. J Clin Sleep Med. 2011;7(6):622–31.

    PubMed  PubMed Central  Google Scholar 

  127. Balliett NE, Davis JL, Miller KE. Efficacy of a brief treatment for nightmares and sleep disturbances for veterans. Psychol Trauma. 2015;7(6):507–15.

    Article  PubMed  Google Scholar 

  128. • Miller K, Cranston C, Simonet D, Pruiksma K, Davis J. The impact of suspected sleep apnea on exposure, relaxation, and rescripting therapy (ERRT): a preliminary examination. J Sleep Disord Med Care. 2018;1(1) This study found symptom levels for participants with suspected OSA remained elevated after ERRT compared to non-apnea, which suggests OSA may be a primary treatment focus.

  129. Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating gess in a diverse population with obstructive sleep apnea: results of a meta-analysis. Arch Intern Med. 2003;163(5):565–71.

    Article  PubMed  Google Scholar 

  130. Stepnowsky CJ, Moore PJ. Nasal CPAP treatment for obstructive sleep apnea: developing a new perspective on dosing strategies and compliance. J Psychosom Res. 2003;54(6):599–605.

    Article  PubMed  Google Scholar 

  131. El-Solh AA, Ayyar L, Akinnusi M, Relia S, Akinnusi O. Positive airway pressure adherence in veterans with posttraumatic stress disorder. Sleep. 2010;33(11):1495–500.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Krakow B, Germain A, Tandberg D, Koss M, Schrader R, Hollifield M, et al. Sleep breathing and sleep movement disorders masquerading as insomnia in sexual-assault survivors. Compr Psychiatry. 2000;41(1):49–56.

    Article  PubMed  CAS  Google Scholar 

  133. Collen JF, Lettieri CJ, Hoffman M. The impact of posttraumatic stress disorder on CPAP adherence in patients with obstructive sleep apnea. J Clin Sleep Med. 2012;8(6):667–72.

    PubMed  PubMed Central  Google Scholar 

  134. •• Lettieri CJ, Williams SG, Collen JF. OSA syndrome and posttraumatic stress disorder: clinical outcomes and impact of positive airway pressure therapy. Chest. 2016;149(2):483–90. This study found that greater use of CPAP was associated with a lower nightmare frequency.

    Article  PubMed  Google Scholar 

  135. • El-Solh AA, Vermont L, Homish GG, Kufel T. The effect of continuous positive airway pressure on post-traumatic stress disorder symptoms in veterans with post-traumatic stress disorder and obstructive sleep apnea: a prospective study. Sleep Med. 2017;33:145–50. This study found that treatment with CPAP had small symptoms reduction in PTSD that remained at 6-month follow-up.

    Article  PubMed  Google Scholar 

  136. • Orr JE, Smales C, Alexander TH, Stepnowsky C, Pillar G, Malhotra A, et al. Treatment of OSA with CPAP is associated with improvement in PTSD symptoms among veterans. J Clin Sleep Med. 2017;13(1):57–63. Evidence showed that treatment with CPAP had small symptoms reduction in PTSD that remained at 6-month follow-up.

    Article  PubMed  PubMed Central  Google Scholar 

  137. • Ullah M, Campbell DG, Bhagat R, Lyons JA, Tamanna S. Improving PTSD symptoms and preventing progression of subclinical PTSD to an overt disorder by treating comorbid OSA with CPAP. J Clin Sleep Med. 2017;13(10):1191–8. Found that treatment with CPAP had small symptoms reduction in PTSD that remained at 6-month follow-up and that CPAP therapy may limit progression of sub-clinical PTSD.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  138. Goldstein LA, Colvonen PJ, Sarmiento KF. Advancing treatment of comorbid PTSD and OSA. J Clin Sleep Med. 2017;13(6):843–4.

    Article  PubMed  PubMed Central  Google Scholar 

  139. Ramar K, Dort LC, Katz SG, Lettieri CJ, Harrod CG, Thomas SM, et al. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015: an American Academy of Sleep Medicine and American Academy of Dental Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2015;11(7):773–827.

    PubMed  PubMed Central  Google Scholar 

  140. Ferguson KA, Cartwright R, Rogers R, Schmidt-Nowara W. Oral appliances for snoring and obstructive sleep apnea: a review. Sleep. 2006;29(2):244–62.

    Article  PubMed  Google Scholar 

  141. Barnes M, McEvoy RD, Banks S, Tarquinio N, Murray CG, Vowles N, et al. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. Am J Respir Crit Care Med. 2004;170(6):656–64.

    Article  PubMed  Google Scholar 

  142. Engleman HM, McDonald JP, Graham D, Lello GE, Kingshott RN, Coleman EL, et al. Randomized crossover trial of two treatments for sleep apnea/hypopnea syndrome: continuous positive airway pressure and mandibular repositioning splint. Am J Respir Crit Care Med. 2002;166(6):855–9.

    Article  PubMed  Google Scholar 

  143. Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000;284(23):3015–21.

    Article  PubMed  CAS  Google Scholar 

  144. •• Iftikhar IH, Bittencourt L, Youngstedt SD, Ayas N, Cistulli P, Schwab R, et al. Comparative efficacy of CPAP, MADs, exercise-training, and dietary weight loss for sleep apnea: a network meta-analysis. Sleep Med. 2017;30:7–14. In a non-PTSD sample, CPAP was efficacious, followed by exercise and dietary weight loss, for reducing AHI.

    Article  PubMed  Google Scholar 

  145. Baddeley JL, Gros DF. Cognitive behavioral therapy for insomnia as a preparatory treatment for exposure therapy for posttraumatic stress disorder. Am J Psychother. 2013;67(2):199–210.

    Google Scholar 

  146. •• Colvonen PJ, Drummond SP, Angkaw AC, Norman SB. Cognitive behavioral therapy for insomnia integrated with prolonged exposure: rationale and pilot study. Psychological Trauma: Theory, Research, Practice, and Policy. Under Review. This study examined CBT-I prior to PE and found statistical and clinical changes in insomnia and PTSD symptoms.

  147. Galatzer-Levy IR, Nickerson A, Litz BT, Marmar CR. Patterns of lifetime PTSD comorbidity: a latent class analysis. Depress Anxiety. 2013;30(5):489–96.

    Article  PubMed  Google Scholar 

  148. Colvonen PJ, Ellison J, Haller M, Norman SB. Examining insomnia and PTSD over time in veterans in residential treatment for substance use disorders and PTSD. Behav Sleep Med. 2018:1–12.

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Acknowledgments

The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. Writing was supported by VA RR&D CDA Grant #1lK2Rx002120-01 (P.J.C.) and by the Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs (L.D.S. and L.A.G.).

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P.J.C., L.D.S., C.S., L.A.G., and S.B.N. each declare no potential conflicts of interest.

M.J.M. is an unpaid member of the scientific advisory board for Owaves.

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Colvonen, P.J., Straus, L.D., Stepnowsky, C. et al. Recent Advancements in Treating Sleep Disorders in Co-Occurring PTSD. Curr Psychiatry Rep 20, 48 (2018). https://doi.org/10.1007/s11920-018-0916-9

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