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Review on Headache Related to Dietary Supplements

  • Uncommon and/or Unusual Headaches and Syndromes (J Ailani, Section Editor)
  • Published:
Current Pain and Headache Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The lifetime prevalence of headaches is 96%. Approximately 11% of the adult population worldwide has a migraine headache. Migraine is a complex disorder that is more than a simple headache. So far, many underlying mechanisms, i.e. inflammatory, vascular, neurogenic have been hypothesized. In recent years evidences proposed that an energy deficit due to changes in mitochondrial function contributes to migraine pathophysiology as an upstream disorder. Recent insights suggested that the coexistence of sensory-stimuli surplus and energy-reserve shortage activate the trigeminovascular system. Some nutrients are considered as essential elements in mitochondrial bioenergetics and some others are known as natural immuno-modulatory components. Also, evidence showed their beneficial effect in headache prophylaxis and treatment. In present study, we aimed to review the available data in this field.

Recent Findings

Vitamin B group, magnesium, and Coenzyme Q10 (CoQ10) are well-known for their function in mitochondrial energy metabolism. On the other hand, studies support their beneficial role in controlling migraine headache symptoms. For instance, daily intake of 400-milligram riboflavin for 3 months resulted in more than 50% reduction in migraine attacks in more than half of the consumers. According to recent evidence, vitamin D and Omega-3 which are considered as famous immune-modulatory compounds are also reported to be effective in migraine prophylaxis. For example, every 22% reduction in migraine headache occurrence was reported for every 5 ng/ml rise in serum vitamin D.

Summary

Supplementation with vitamin B group, CoQ10, magnesium, vitamin D and Omega-3 could be considered as an effective, less costly strategy in headache/migraine prophylaxis.

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Article Open access 14 November 2019

Soodeh Razeghi Jahromi, Zeinab Ghorbani, … On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)

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  1. Shadi Ariyanfar and Soodeh Razeghi Jahromi contributed equally to this work.

Authors and Affiliations

  1. Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, USA

    Shadi Ariyanfar

  2. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soodeh Razeghi Jahromi

  3. Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mansoureh Togha

  4. Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

    Zeinab Ghorbani

Authors
  1. Shadi Ariyanfar
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  2. Soodeh Razeghi Jahromi
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  3. Mansoureh Togha
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  4. Zeinab Ghorbani
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Corresponding author

Correspondence to Mansoureh Togha.

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This article is part of the Topical Collection on Uncommon and/or Unusual Headaches and Syndromes

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Ariyanfar, S., Razeghi Jahromi, S., Togha, M. et al. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep 26, 193–218 (2022). https://doi.org/10.1007/s11916-022-01019-9

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