Abstract
Chronic pain has long been considered an important risk factor for suicidal behavior. Less well understood are the factors associated with the increased risk for suicide death within chronic pain populations. The purpose of this review is to examine recent research with regard to rates of and risk factors for suicide mortality in patients with chronic musculoskeletal pain. We conclude that patients with a number of chronic pain states are at increased risk for suicide death, and that this risk appears to be due, at least in part, to other well-known correlates of pain such as depression and substance use disorders. However, in all likelihood, there are aspects of chronic pain itself that add uniquely to an individual’s suicide risk profile. Lastly, we address a theoretical perspective and offer recommendations for clinical practice.

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Centers for Disease Control and Prevention. Web-based Injury Statistics Query and Reporting System (WISQARS). Fatal Injury Reports. Atlanta, GA: National Center for Injury Prevention and Control. http://www.cdc.gov/injury/wisqars/index.html. Accessed 15 Nov 2013.
Ilgen MA, Zivin K, Austin KL, Bohnert AS, Czyz EK, Valenstein M, et al. Severe pain predicts greater likelihood of subsequent suicide. Suicide Life Threat Behav. 2010;40:597–608.
Bohman H, Jonsson U, Paaren A, von Knorring L, Olsson G, von Knorring AL. Prognostic significance of functional somatic symptoms in adolescence: a 15-year community-based follow-up study of adolescents with depression compared with healthy peers. BMC Psychiatry. 2012;12:90. PMC3439696.
Fishbain DA, Bruns D, Disorbio JM, Lewis JE. Risk for five forms of suicidality in acute pain patients and chronic pain patients vs pain-free community controls. Pain Med. 2009;10:1095–105.
Tang NK, Crane C. Suicidality in chronic pain: a review of the prevalence, risk factors and psychological links. Psychol Med. 2006;36:575–86.
Institute of Medicine. Relieving pain in America a blueprint for transforming prevention, care, education, and research. In. Washington, DC: National Academy of Sciences; 2011.
Lu D, Fall K, Sparen P, Ye W, Adami HO, Valdimarsdottir U, Fang F. Suicide and suicide attempt after a cancer diagnosis among young individuals. Ann Oncol. 2013.
Dreyer L, Kendall S, Danneskiold-Samsoe B, Bartels EM, Bliddal H. Mortality in a cohort of Danish patients with fibromyalgia: increased frequency of suicide. Arthritis Rheum. 2010;62:3101–8. The risk for suicide in patients with fibromyalgia may be particularly high, especially in those with psychiatric comorbidity. The risk was found to be higher at diagnosis, and remained elevated five years later.
Wolfe F, Hassett AL, Walitt B, Michaud K. Mortality in fibromyalgia: a study of 8,186 patients over thirty-five years. Arthritis Care Res (Hoboken). 2011;63:94–101.
McBeth J, Silman AJ, Macfarlane GJ. Association of widespread body pain with an increased risk of cancer and reduced cancer survival: a prospective, population-based study. Arthritis Rheum. 2003;48:1686–92.
McBeth J, Symmons DP, Silman AJ, Allison T, Webb R, Brammah T, et al. Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality. Rheumatology (Oxford). 2009;48:74–7. PMC2639482.
Macfarlane GJ, McBeth J, Silman AJ. Widespread body pain and mortality: prospective population based study. BMJ. 2001;323:662–5. PMC55925.
Kikuchi N, Ohmori-Matsuda K, Shimazu T, Sone T, Kakizaki M, Nakaya N, et al. Pain and risk of completed suicide in Japanese men: a population-based cohort study in Japan (Ohsaki Cohort Study). J Pain Symptom Manag. 2009;37:316–24.
Ilgen MA, Kleinberg F, Ignacio RV, Bohnert AS, Valenstein M, McCarthy JF, et al. Noncancer pain conditions and risk of suicide. JAMA Psychiatry. 2013;70:692–7. This study demonstrated that the risk for suicide varies among chronic pain patient populations. The authors found that patients with back pain, migraine, and psychogenic pain were at the greatest risk.
Löfman S, Rasanen P, Hakko H, Mainio A. Suicide among persons with back pain: a population-based study of 2310 suicide victims in Northern Finland. Spine (Phila Pa 1976) 2011;36:541–8.
Nock MK, Borges G, Bromet EJ, Cha CB, Kessler RC, Lee S. Suicide and suicidal behavior. Epidemiol Rev. 2008;30:133–54. PMC2576496.
Nitter AK, Forseth KO. Mortality rate and causes of death in women with self-reported musculoskeletal pain: results from a 17-year follow-up study. Scand J Pain. 2013;4:86–92.
Madadi P, Hildebrandt D, Lauwers AE, Koren G. Characteristics of opioid-users whose death was related to opioid-toxicity: a population-based study in Ontario. Can PLoS One. 2013;8:e60600. PMC3618438.
Pereira A, Gitlin MJ, Gross RA, Posner K, Dworkin RH. Suicidality associated with antiepileptic drugs: implications for the treatment of neuropathic pain and fibromyalgia. Pain. 2013;154:345–9.
Smith MT, Edwards RR, Robinson RC, Dworkin RH. Suicidal ideation, plans, and attempts in chronic pain patients: factors associated with increased risk. Pain. 2004;111:201–8.
Timonen M, Viilo K, Hakko H, Sarkioja T, Ylikulju M, Meyer-Rochow VB, et al. Suicides in persons suffering from rheumatoid arthritis. Rheumatology (Oxford). 2003;42:287–91.
Goldsmith SK, Pellmar TC, Kleinman AM, Bunney WE. Reducing suicide. A national imperative. Washington, DC: Institute of Medicine. The National Academies Press; 2002.
Calandre EP, Vilchez JS, Molina-Barea R, Tovar MI, Garcia-Leiva JM, Hidalgo J, et al. Suicide attempts and risk of suicide in patients with fibromyalgia: a survey in Spanish patients. Rheumatology (Oxford). 2011;50:1889–93.
Okifuji A, Benham B. Suicidal and self-harm behaviors in chronic pain patients. J Appl Biobehav Res. 2011;16:57–77.
Fitzcharles MA, Ste-Marie PA, Gamsa A, Ware MA, Shir Y. Opioid use, misuse, and abuse in patients labeled as fibromyalgia. Am J Med. 2011;124:955–60.
Racine M, Choiniere M, Nielson WR. Predictors of Suicidal Ideation in Chronic Pain Patients: An Exploratory Study. Clin J Pain. 2013. Twenty-four percent of patients with chronic pain were found to have current suicidal ideation. Poor perceived mental health, pain-related helplessness, and a history of substance abuse were associated with increased risk for suicidal ideation.
Fishbain DA, Bruns D, Meyer LJ, Lewis JE, Gao J, Disorbio JM. Exploration of the relationship between disability perception, preference for death over disability, and suicidality in patients with acute and chronic pain. Pain Med. 2012;13:552–61.
Van Orden KA, Witte TK, Cukrowicz KC, Braithwaite SR, Selby EA, Joiner Jr TE. The interpersonal theory of suicide. Psychol Rev. 2010;117:575–600. PMC3130348.
Wilson KG, Kowal J, Henderson PR, McWilliams LA, Peloquin K. Chronic pain and the interpersonal theory of suicide. Rehabil Psychol. 2013;58:111–5.
Kanzler KE, Bryan CJ, McGeary DD, Morrow CE. Suicidal ideation and perceived burdensomeness in patients with chronic pain. Pain Pract. 2012;12:602–9.
Franklin JC, Hessel ET, Prinstein MJ. Clarifying the role of pain tolerance in suicidal capability. Psychiatry Res. 2011;189:362–7.
Hawton K, van Heeringen K. Suicide. Lancet. 2009;373:1372–81.
van Heeringen C, Bijttebier S, Godfrin K. Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev. 2011;35:688–98.
Goesling J, Clauw DJ, Hassett AL. Pain and depression: an integrative review of neurobiological and psychological factors. Curr Psychiatry Rep. 2013;15:421.
Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, et al. Roles of the insular cortex in the modulation of pain: insights from brain lesions. J Neurosci. 2009;29:2684–94. PMC2748680.
Legrain V, Iannetti GD, Plaghki L, Mouraux A. The pain matrix reloaded: a salience detection system for the body. Prog Neurobiol. 2011;93:111–24.
Posner K, Brown GK, Stanley B, Brent DA, Yershova KV, Oquendo MA, et al. The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am J Psychiatry. 2011;168:1266–77.
Brown GK, Ten Have T, Henriques GR, Xie SX, Hollander JE, Beck AT. Cognitive therapy for the prevention of suicide attempts: a randomized controlled trial. JAMA. 2005;294:563–70.
Linehan MM, Comtois KA, Murray AM, Brown MZ, Gallop RJ, Heard HL, et al. Two-year randomized controlled trial and follow-up of dialectical behavior therapy vs therapy by experts for suicidal behaviors and borderline personality disorder. Arch Gen Psychiatry. 2006;63:757–66.
Acknowledgments
This work was financially supported by the Metzger Family Foundation (ALH) and the California State University Sally Casanova Pre-Doctoral Scholarship (JKA).
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Conflict of Interest
Dr. Afton L. Hassett received a grant from Bristol-Myers Squibb. Dr. Hassett received payment for development of educational presentations, including service on speakers’ bureaus from inPractice and travel/accommodations expenses covered or reimbursed by the American College of Rheumatology.
Mr. Jordan K. Aquino received a grant from California State University (Sally Casanova Pre-Doctoral Scholarship).
Dr. Mark A. Ilgen declares no potential conflict of interest.
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Hassett, A.L., Aquino, J.K. & Ilgen, M.A. The Risk of Suicide Mortality in Chronic Pain Patients. Curr Pain Headache Rep 18, 436 (2014). https://doi.org/10.1007/s11916-014-0436-1
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DOI: https://doi.org/10.1007/s11916-014-0436-1