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Rheumatic mimics and selected triggers of fibromyalgia

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Abstract

Fibromyalgia is a chronic pain syndrome of unknown etiology characterized by diffuse pain and tender points, which have been present for more than 3 months. Many patients with systemic illnesses can have diffuse pain similar to that found in fibromyalgia, including rheumatic diseases such as polymyalgia rheumatica, rheumatoid arthritis, idiopathic inflammatory myopathy, systemic lupus erythematosus, and joint hypermobility. Osteomalacia and thyroid disease are also in the differential diagnosis of diffuse pain and are imminently treatable. In addition, there has been interest throughout the past 10 years in infectious diseases including hepatitis C, Lyme disease, coxsackie B, HIV, and parvovirus infection, which may cause or trigger fibromyalgia. This paper provides a framework to use when identifying these diseases as part of the evaluation of a patient with chronic widespread musculoskeletal pain.

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References and Recommended Reading

  1. Wolfe F, Smythe HA, Yunus MB, et al.: The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia: Report of the Multicenter Criteria Committee. Arthritis Rheum 1990, 33(2):160–172.

    Article  PubMed  CAS  Google Scholar 

  2. Wolfe F, Ross K, Anderson J, et al.: The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995, 38(1):19–28.

    Article  PubMed  CAS  Google Scholar 

  3. Buskila D, Neumann L: Musculoskeletal injury as a trigger for fibromyalgia/post-traumatic fibromyalgia. Curr Rheumatol Rep 2000, 2(2):104–108.

    Article  PubMed  CAS  Google Scholar 

  4. Buskila D, Neumann L, Vaisberg G, et al.: Increased rates of fibromyalgia following cervical spine injury: a controlled study of 161 cases of traumatic injury. Arthritis Rheum 1997, 40(3):446–452.

    Article  PubMed  CAS  Google Scholar 

  5. Buskila D, Shnaider A, Neumann L, et al.: Fibromyalgia in hepatitis C virus infection: another infectious disease relationship. Arch Intern Med 1997, 157(21):2497–2500.

    Article  PubMed  CAS  Google Scholar 

  6. Boisset-Pioro MH, Esdaile JM, Fitzcharles MA: Sexual and physical abuse in women with fibromyalgia syndrome. Arthritis Rheum 1995, 38(2):235–241.

    Article  PubMed  CAS  Google Scholar 

  7. Drewes AM: Pain and sleep disturbances with special reference to fibromyalgia and rheumatoid arthritis. Rheumatology (Oxford) 1999, 38(11):1035–1038.

    Article  CAS  Google Scholar 

  8. Drewes AM, Gade K, Nielsen KD, et al.: Clustering of sleep electroencephalographic patterns in patients with the fibromyalgia syndrome. Br J Rheumatol 1995, 34(12):1151–1156.

    Article  PubMed  CAS  Google Scholar 

  9. Branco J, Atalaia A, Paiva T: Sleep cycles and alpha-delta sleep in fibromyalgia syndrome. J Rheumatol 1994, 21(6):1113–1117.

    PubMed  CAS  Google Scholar 

  10. Affleck G, Urrows S, Tennen H, et al.: Sequential daily relations of sleep, pain intensity, and attention to pain among women with fibromyalgia. Pain 1996, 68(2-3):363–368.

    Article  PubMed  CAS  Google Scholar 

  11. Nash P, Chard M, Hazleman B: Chronic coxsackie B infection mimicking primary fibromyalgia. J Rheumatol 1989, 16(11):1506–1508.

    PubMed  CAS  Google Scholar 

  12. Berg AM, Naides SJ, Simms RW: Established fibromyalgia syndrome and parvovirus B19 infection. J Rheumatol 1993, 20(11):1941–1943.

    PubMed  CAS  Google Scholar 

  13. Leventhal LJ, Naides SJ, Freundlich B: Fibromyalgia and parvovirus infection. Arthritis Rheum 1991, 34(10):1319–1324.

    Article  PubMed  CAS  Google Scholar 

  14. Griep EN, Boersma JW, de Kloet ER: Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome. J Rheumatol 1993, 20(3):469–474.

    PubMed  CAS  Google Scholar 

  15. Demitrack MA, Crofford LJ: Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis disregulation in fibromyalgia and chronic fatigue syndrome. Ann N Y Acad Sci 1998, 840:684–697.This paper describes hypothalamic-pituitary-adrenal perturbations in fibromyalgia, providing an explanation for the apparent multisystem involvement.

    Article  PubMed  CAS  Google Scholar 

  16. Crofford LJ, Pillemer SR, Kalogeras KT, et al.: Hypothalamicpituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 1994, 37(11):1583–1592.

    Article  PubMed  CAS  Google Scholar 

  17. Rivera J, de Diego A, Trinchet M, Garcia MA: Fibromyalgiaassociated hepatitis C virus infection. Br J Rheumatol 1997, 36(9):981–985.

    Article  PubMed  CAS  Google Scholar 

  18. Barkhuizen A, Rosen HR, Wolf S, et al.: Musculoskeletal pain and fatigue are associated with chronic hepatitis C: a report of 239 hepatology clinic patients. Am J Gastroenterol 1999, 94(5):1355–1360.This study confirms the frequent occurrence of musculoskeletal pain and fatigue in patients with chronic hepatitis C infection independent of the severity of liver disease or mode of acquiring the infection.

    PubMed  CAS  Google Scholar 

  19. Barkhuizen A, Bennett RM: Hepatitis C infection presenting with rheumatic manifestations. J Rheumatol 1997, 24(6):1238–1239.

    PubMed  CAS  Google Scholar 

  20. Steere AC, Taylor E, McHugh GL, Logigian EL: The overdiagnosis of Lyme disease. JAMA 1993, 269(14):1812–1816.

    Article  PubMed  CAS  Google Scholar 

  21. Dinerman H, Steere AC: Lyme disease associated with fibromyalgia. Ann Intern Med 1992, 117(4):281–285.

    PubMed  CAS  Google Scholar 

  22. Hunder GG: Clinical features of GCA/PMR. Clin Exp Rheumatol 2000, 18(4 Suppl 20):S6-S8.

    PubMed  CAS  Google Scholar 

  23. Proven A, Gabriel SE, O’Fallon WM, Hunder GG: Polymyalgia rheumatica with low erythrocyte sedimentation rate at diagnosis. J Rheumatol 1999, 26(6):1333–1337.

    PubMed  CAS  Google Scholar 

  24. Gonzalez-Gay MA, Rodriguez-Valverde V, Blanco R, et al.: Polymyalgia rheumatica without significantly increased erythrocyte sedimentation rate: a more benign syndrome. Arch Intern Med 1997, 157(3):317–320.

    Article  PubMed  CAS  Google Scholar 

  25. Helfgott SM, Kieval RI: Polymyalgia rheumatica in patients with a normal erythrocyte sedimentation rate. Arthritis Rheum 1996, 39(2):304–307.

    Article  PubMed  CAS  Google Scholar 

  26. Simms RW, Zerbini CA, Ferrante N, et al.: Fibromyalgia syndrome in patients infected with human immunodeficiency virus. The Boston City Hospital Clinical AIDS Team. Am J Med 1992, 92(4):368–374.

    Article  PubMed  CAS  Google Scholar 

  27. Buskila D, Gladman DD, Langevitz P, et al.: Fibromyalgia in human immunodeficiency virus infection. J Rheumatol 1990, 17(9):1202–1206.

    PubMed  CAS  Google Scholar 

  28. Salvarani C, Cantini F, Olivieri I, et al.: Proximal bursitis in active polymyalgia rheumatica. Ann Intern Med 1997, 127(1):27–31.

    PubMed  CAS  Google Scholar 

  29. Salvarani C, Gabriel SE, O’Fallon WM, Hunder GG: Epidemiology of polymyalgia rheumatica in Olmsted County, Minnesota, 1970–1991. Arthritis Rheum 1995, 38(3):369–0373.

    Article  PubMed  CAS  Google Scholar 

  30. Narvaez J, Nolla-Sole JM, Valverde-Garcia J, Roig-Escofet D: Sex differences in temporal arteritis and polymyalgia rheumatica. J Rheumatol 2002, 29(2):321–325.

    PubMed  Google Scholar 

  31. Arslan S, Yunus MB, Aldag JC: Fibromyalgia syndrome (FMS) in rheumatoid arthritis [Abstract]. Arthritis Rheum 2002, 44(suppl 9):S71.

    Google Scholar 

  32. Patrick M, Buchbinder R, Jolley D, et al.: Incidence of inflammatory myopathies in Victoria, Australia, and evidence of spatial clustering. J Rheumatol 1999, 26(5):1094–1100.

    PubMed  CAS  Google Scholar 

  33. Oddis CV, Conte CG, Steen VD, Medsger TA, Jr: Incidence of polymyositis-dermatomyositis: a 20-year study of hospital diagnosed cases in Allegheny County, PA 1963–1982. J Rheumatol 1990, 17(10):1329–1334.

    PubMed  CAS  Google Scholar 

  34. Buskila D: Hepatitis C-associated arthritis. Curr Opin Rheumatol 2000, 12(4):295–299.

    Article  PubMed  CAS  Google Scholar 

  35. Lawrence RC, Helmick CG, Arnett FC, et al.: Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998, 41(5):778–799.

    Article  PubMed  CAS  Google Scholar 

  36. Middleton GD, McFarlin JE, Lipsky PE: The prevalence and clinical impact of fibromyalgia in systemic lupus erythematosus. Arthritis Rheum 1994, 37(8):1181–1188.

    Article  PubMed  CAS  Google Scholar 

  37. Hudson N, Starr MR, Esdaile JM, Fitzcharles MA: Diagnostic associations with hypermobility in rheumatology patients. Br J Rheumatol 1995, 34(12):1157–1161.

    Article  PubMed  CAS  Google Scholar 

  38. Karaaslan Y, Haznedaroglu S, Ozturk M: Joint hypermobility and primary fibromyalgia: a clinical enigma. J Rheumatol 2000, 27(7):1774–1776.

    PubMed  CAS  Google Scholar 

  39. Hsu VM, Patella SJ, Sigal LH: "Chronic Lyme disease" as the incorrect diagnosis in patients with fibromyalgia. Arthritis Rheum 1993, 36(11):1493–1500.

    Article  PubMed  CAS  Google Scholar 

  40. Goldenberg DL: Do infections trigger fibromyalgia? Arthritis Rheum 1993, 36(11):1489–1492.

    Article  PubMed  CAS  Google Scholar 

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Daoud, K.F., Barkhuizen, A. Rheumatic mimics and selected triggers of fibromyalgia. Current Science Inc 6, 284–288 (2002). https://doi.org/10.1007/s11916-002-0049-y

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