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Contemporary Treatment Approaches to Sinonasal Mucosal Melanoma

  • Head and Neck Cancers (EY Hanna, Section Editor)
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Abstract

Sinonasal mucosal melanoma (SNMM) is a rare oncological entity that comprises most head and neck mucosal melanomas. SNMM has distinctive genetic background, different from cutaneous melanoma. Survival outcomes among SNMM patients are poor; while there is no clear consensus on the optimal management of SNMM, the primary treatment modality is generally considered to be wide surgical excision, and radiation therapy (RT) is often used in the postoperative adjuvant setting to improve locoregional control. Systemic therapies have demonstrated little or no survival benefit, and most SNMM patients die of distant metastatic disease. Owing to the rarity of the disease, the literature describing treatment approaches for SNMM is lacking and largely limited to isolated case reports and retrospective series. Here, we describe contemporary diagnostic and therapeutic approaches to SNMM based on the most recent molecular and outcome data.

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We acknowledge the Department of Scientific Publications, The University of Texas MD Anderson Cancer Center.

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  1. Department of Head and Neck Surgery, Unit 1445, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA

    Moran Amit & Ehab Y. Hanna

  2. Department of Otolaryngology Head and Neck Surgery, Rambam Healthcare Campus, The Technion, Israel Institute of Technology, Haifa, Israel

    Shorook Na’ara

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Amit, M., Na’ara, S. & Hanna, E.Y. Contemporary Treatment Approaches to Sinonasal Mucosal Melanoma. Curr Oncol Rep 20, 10 (2018). https://doi.org/10.1007/s11912-018-0660-7

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