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The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries

  • Neurotrauma (M Kumar, Section Editor)
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Abstract

Traumatic brain injury (TBI) and traumatic spinal cord injury (SCI), collectively termed neurotrauma, are two parallel neurological conditions that can cause long-lasting neurological impairment and other comorbidities in patients, while at the same time, can create a high burden to society. To date, there are still no FDA-approved therapeutic interventions for either TBI or SCI. Recent advances in proteomic technologies, including tandem mass spectrometry, as well as imaging mass spectrometry, have enabled new approaches to study the differential proteome in TBI and SCI with the use of either animal disease models and/or biosamples from clinical observational studies. Thus, the applications of state-of-the-art proteomic method hold promises in shedding light on identifying clinically useful neurotrauma “biomarkers” and/or in identifying distinct and, otherwise, unobvious systems pathways or “key drivers” that can be further exploited as new therapeutic intervention targets.

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    Authors and Affiliations

    1. Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Department of Psychiatry, University of Florida, Gainesville, FL, 32611, USA

      George Anis Sarkis, Manasi D. Mangaonkar, Ahmed Moghieb, Hamad Yadikar, Zhihui Yang, Firas Kobeissy & Kevin K. W. Wang

    2. Department of Neuroscience, University of Florida, Gainesville, FL, 32611, USA

      Kevin K. W. Wang

    3. Department of Physiological Sciences, University of Florida, Gainesville, FL, 32611, USA

      Kevin K. W. Wang

    4. Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA

      George Anis Sarkis, Manasi D. Mangaonkar, Brian Lelling, Michael Guertin, Hamad Yadikar & Kevin K. W. Wang

    5. Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, PO Box 426, Alexandria, 21321, Egypt

      George Anis Sarkis

    6. Biological Sciences Division/Integrative Omics, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA, 99352, USA

      Ahmed Moghieb

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    George Anis Sarkis, Manasi D. Mangaonkar, Ahmed Moghieb, Brian Lelling, Michael Guertin, Hamad Yadikar, Zhihui Yang, Firas Kobeissy, and Kevin K.W. Wang declare that they have no conflict of interest.

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    George Anis Sarkis, Manasi D. Mangaonkar, Ahmed Moghieb, Firas Kobeissy and Kevin K. W. Wang contributed equally to this work.

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    Sarkis, G.A., Mangaonkar, M.D., Moghieb, A. et al. The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries. Curr Neurol Neurosci Rep 17, 23 (2017). https://doi.org/10.1007/s11910-017-0736-z

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