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Mpox in 2023: Current Epidemiology and Management

  • Tropical, Travel and Emerging Infections (LH Chen and F Norman, Section Editors)
  • Published:
Current Infectious Disease Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The 2022 global mpox outbreak is a significant public health challenge. This review provides a summary of recent advancements in mpox phylogenetics, epidemiology, transmission, clinical presentation, treatment, and vaccination.

Recent Findings

The 2022 outbreak saw a shift in epidemiology, with human-to-human transmission, particularly among men who have sex with men (MSM), becoming the primary mode of spread. Among IIb.B.1 sequences, there is evidence for an emerging human-adapted monkeypox virus (MPXV). Antiviral treatments like tecovirimat have shown promise in severe cases. Two doses of the non-replicative 3rd generation vaccine MVA-BN provide better protection than a single dose.

Summary

This outbreak underscores the importance of global surveillance, prompt response, and effective vaccination strategies in managing emerging infectious diseases. Efforts to destigmatize the disease and increase awareness among high-risk populations are vital in curbing transmission. Continued research and international collaboration are essential for understanding the MPXV and improving preparedness for future outbreaks.

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Authors and Affiliations

  1. J.D. MacLean Centre for Tropical Diseases at McGill University, 1001 Boulevard Decarie, Montreal, QC, H4A 3J1, Canada

    Sapha Barkati

  2. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montreal, QC, Canada

    Sapha Barkati, Luke B. Harrison & Marina B. Klein

  3. Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Sapha Barkati & Marina B. Klein

  4. Department of Medicine, Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC, Canada

    Marina B. Klein

  5. Infectious Diseases Department, National Referral Unit for Tropical Diseases, Ramón y Cajal University Hospital, IRYCIS, CIBERINFEC, Madrid, Spain

    Francesca F. Norman

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  1. Sapha Barkati
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  2. Luke B. Harrison
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  3. Marina B. Klein
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  4. Francesca F. Norman
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Contributions

S. B., L. B. H., F. F. N., and M. B. K. contributed to the conception and design of the work. S. B., L. B. H., and F. F. N drafted the manuscript. S. B., L. B. H., F. F. N., and M. B. K. revised the manuscript critically for important intellectual content. All authors reviewed the manuscript and approved the version to be published.

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Correspondence to Sapha Barkati.

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Barkati, S., Harrison, L.B., Klein, M.B. et al. Mpox in 2023: Current Epidemiology and Management. Curr Infect Dis Rep 25, 199–209 (2023). https://doi.org/10.1007/s11908-023-00812-w

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