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Role of Collectrin, an ACE2 Homologue, in Blood Pressure Homeostasis

  • Hypertension and the Kidney (RM Carey, Section Editor)
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Abstract

Collectrin (Tmem27) is a transmembrane glycoprotein that is highly expressed in the kidney and vascular endothelium. It is a homologue of the angiotensin-converting enzyme 2 (ACE2) but harbors no catalytic domain. In the extravascular tissues of the kidney, collectrin is localized to the proximal tubule and collecting duct. Collectrin-deficient mice are featured with hypertension and exaggerated salt sensitivity. These phenotypes are associated with impaired uptake of the nitric oxide precursor l-arginine and the expression of its amino acid transporters, CAT-1 and y+LAT1, in endothelial cells. In addition, collectrin-deficient mice display decreased dimerization of nitric oxide synthase and decreased nitric oxide synthesis, but enhanced superoxide generation, suggesting that deletion of collectrin leads to a state of nitric oxide synthase uncoupling. These findings suggest that collectrin plays a protective role against hypertension. The collectrin knockout mouse represents a unique model for hypertension research. Furthermore, collectrin may serve as a novel therapeutic target in the treatment of hypertension.

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Acknowledgment

This work was supported by NIH/NIDDK T32 DK072922 Training Grant, Division of Nephrology, University of Virginia to P.L.C.

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Pei-Lun Chu and Thu H. Le declare no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. University of Virginia Health System, Division of Nephrology, Department of Medicine, University of Virginia, PO Box 800133, Charlottesville, VA, 22908, USA

    Pei-Lun Chu & Thu H. Le

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Correspondence to Thu H. Le.

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This article is part of the Topical Collection on Hypertension and the Kidney

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Chu, PL., Le, T.H. Role of Collectrin, an ACE2 Homologue, in Blood Pressure Homeostasis. Curr Hypertens Rep 16, 490 (2014). https://doi.org/10.1007/s11906-014-0490-4

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