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Fructose and Uric Acid: Is There a Role in Endothelial Function?

  • Hypertension and Metabolic Syndrome (JR Sowers and AT Whaley-Connell, Section Editors)
  • Published:
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Abstract

Population level data support that consumption of fructose and fructose-based sweeteners has dramatically increased and suggest that high dietary intake of fructose is an important factor in the development of the cardiorenal metabolic syndrome (CRS). The CRS is a constellation of cardiac, kidney and metabolic disorders including insulin resistance, obesity, metabolic dyslipidemia, high blood pressure, and evidence of early cardiac and kidney disease. The consequences of fructose metabolism may result in intracellular ATP depletion, increased uric acid production, oxidative stress, inflammation, and increased lipogenesis, which are associated with endothelial dysfunction. Endothelial dysfunction is an early manifestation of vascular disease and a driver for the development of CRS. A better understanding of fructose overconsumption in the development of CRS may provide new insights into pathogenesis and future therapeutic strategies.

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Acknowledgments

The authors would like to thank Brenda Hunter for her editorial assistance. This research was supported by National Institutes of Health grants HL-73101 and HL-107910 to J.R.S. and AG-040638 to A.W.-C. and the Veterans Affairs Merit System 0018 (J.R.S.) and CDA-2 (A.W.-C.).

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA

    Guanghong Jia, Annayya R. Aroor, Adam T. Whaley-Connell & James R. Sowers

  2. Division of Nephrology and Hypertension, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA

    Adam T. Whaley-Connell

  3. Research Service Harry S Truman Memorial Veterans Hospital, Research Service, 800 Hospital Dr, Columbia, MO, 65201, USA

    Guanghong Jia, Annayya R. Aroor, Adam T. Whaley-Connell & James R. Sowers

  4. Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, MA415 Medical Sciences Building, One Hospital Drive, Columbia, MO, 65212, USA

    James R. Sowers

  5. Diabetes and Cardiovascular Center, University of Missouri School of Medicine, Columbia, MO, USA

    Guanghong Jia, Annayya R. Aroor, Adam T. Whaley-Connell & James R. Sowers

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  1. Guanghong Jia
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  2. Annayya R. Aroor
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Correspondence to James R. Sowers.

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Conflict of Interest Guanghong Jia, Annayya R. Aroor, Adam T. Whaley-Connell, and James R. Sowers declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Hypertension and Metabolic Syndrome

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Jia, G., Aroor, A.R., Whaley-Connell, A.T. et al. Fructose and Uric Acid: Is There a Role in Endothelial Function?. Curr Hypertens Rep 16, 434 (2014). https://doi.org/10.1007/s11906-014-0434-z

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