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DILI Associated with Skin Reactions

  • Drug-Induced Liver Injury (NP Chalasani and MS Ghabril, Section Editors)
  • Published:
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Abstract

Purpose of Review

Adverse drug reactions (ADR) frequently involve the liver and skin in the form of drug-induced liver injury or cutaneous drug eruption.

Recent Findings

Skin ADR can range from harmless rash to severe skin manifestations such as drug rash with eosinophilia and systemic symptom syndrome (DRESS syndrome), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP), all of which can be associated with severe outcome, including a 30% mortality rate in case of TEN. The association with co-occurring liver injury varies and in DRESS and SJS/TEN can contribute to substantial morbidity and mortality.

Summary

Liver and skin ADR are frequent but rarely severe; however, if severe, they are not uncommonly fatal.

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Authors and Affiliations

  1. Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA

    Sahand Rahnama-Moghadam

  2. Division of Gastroenterology, East Carolina University, Greenville, NC, USA

    Hans L. Tillmann

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  1. Sahand Rahnama-Moghadam
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Correspondence to Sahand Rahnama-Moghadam.

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Conflict of Interest

Sahand Rahnama-Moghadam declares no conflicts of interest. Hans L. Tillmann reports that his spouse is a full-time employee of AbbVie; reports grants from NIH-NIDDK, during the conduct of the study; reports personal fees from AbbVie, Abbott, and Gilead for stocks; and reports personal fees from Novartis and Novo Nordisk for consulting, outside the submitted work.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Drug-Induced Liver Injury

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Rahnama-Moghadam, S., Tillmann, H.L. DILI Associated with Skin Reactions. Curr Hepatology Rep 17, 225–234 (2018). https://doi.org/10.1007/s11901-018-0414-x

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