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Spontaneous Mutations in the HBV Genome and their Clinical Implications

  • Hepatitis B: Therapeutics (P Martin and WG Cooksley, Section Editors)
  • Published:
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Abstract

Chronic hepatitis B infection remains a significant cause of morbidity and mortality worldwide despite the availability of an effective vaccine. The clinical management of chronic hepatitis B infection is complex often requiring the use of nucleotide analogs as well as immune modulators. The natural history and response to therapy are affected by the presence of naturally occurring mutations in the HBV genome particularly those in the basal core promoter and precore sites. Understanding the role of these mutations in outcome of infection and response to therapy can enable physicians to customize management in order to achieve optimal clinical outcomes.

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Conflict of Interest

Pejman G. Mansourian declares that he has no conflict of interest.

Marc G. Ghany declares that he has no conflict of interest.

Emmanuel Thomas declares that he has no conflict of interest.

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Authors and Affiliations

  1. Schiff Center For Liver Diseases, University of Miami Miller School of Medicine, Miami, FL, USA

    Pejman G. Mansourian & Emmanuel Thomas

  2. Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA

    Marc G. Ghany

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  1. Pejman G. Mansourian
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Correspondence to Emmanuel Thomas.

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Mansourian, P.G., Ghany, M.G. & Thomas, E. Spontaneous Mutations in the HBV Genome and their Clinical Implications. Curr Hepatitis Rep 12, 79–87 (2013). https://doi.org/10.1007/s11901-013-0170-x

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