Abstract
In patients with heart failure (HF), altered breathing patterns, including periodic breathing, Cheyne-Stokes breathing, and oscillatory ventilation, are seen in several situations. Since all forms of altered breathing cause similar detrimental effects on clinical outcomes, they may be considered collectively as an “altered breathing syndrome.” Altered breathing syndrome should be recognized as a comorbid condition of HF and as a potential therapeutic target. In this review, we discuss mechanisms and therapeutic options of altered breathing while sleeping, while awake at rest, and during exercise.
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Conflict of Interest
Yasuhiro Tomita declares that he has no conflict of interest.
Takatoshi Kasai has received unrestricted research funding through grants from Philips Respironics, Teijin Home Healthcare, and Fukuda Denshi.
Tomohiko Kisaka has received unrestricted research funding through a grant from Fukuda Health Foundation, Tokyo, Japan.
Harry B. Rossiter declares that he has no conflict of interest.
Yasuki Kihara declares that he has no conflict of interest.
Karlman Wasserman declares that he has no conflict of interest.
Hiroyuki Daida has received compensation for service as a consultant and financial support through grants from Teijin Pharma; AstraZeneca K.K.; Shionogi & Co., Ltd.; Kowa Pharmaceutical Company, Ltd.; Pfizer; Dainippon Sumitomo Pharma Co., Ltd.; Otsuka Pharmaceutical Co., Ltd.; Sanofi-Aventis K.K.; MSD K.K.; Novartis Pharma K.K.; Astellas Pharma, Inc.; Nippon Boehringer Ingelheim Co., Ltd.; Takeda Pharmaceutical Co., Ltd.; Bristol-Myers Squibb; Mochida Pharmaceutical Co., Ltd.; Bayer Yakuhin, Ltd.; Daiichi-Sankyo Co., Ltd.; Mitsubishi Tanabe Pharma Corp.; Kissei Pharmaceutical Co., Ltd.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
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This paper is partly supported by a Grant-in-Aid for Scientific Research (C) (Grant Number 26507010) and a grant to the Respiratory Failure Research Group from the Ministry of Health, Labour and Welfare, Japan.
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This article is part of the Topical Collection on Management of Heart Failure
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Tomita, Y., Kasai, T., Kisaka, T. et al. Altered Breathing Syndrome in Heart Failure: Newer Insights and Treatment Options. Curr Heart Fail Rep 12, 158–165 (2015). https://doi.org/10.1007/s11897-014-0250-4
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DOI: https://doi.org/10.1007/s11897-014-0250-4