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Circulating Biomarkers in Patients with Heart Failure and Preserved Ejection Fraction

  • Pathophysiology of Myocardial Failure (IS Anand and M Sarraf, Section Editors)
  • Published:
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Abstract

Patients with heart failure with preserved ejection fraction (HF-PEF) comprise a growing proportion of the overall HF burden. The pathophysiology of HF-PEF is complex, and relates to the interplay between cardiac risk factors (notably diabetes/insulin resistance, hypertension), systemic inflammation, and comorbid medical illness (e.g. chronic kidney disease) that conspire to promote endothelial dysfunction, ventricular-vascular stiffening, and diastolic dysfunction. Efficient diagnosis and optimal therapy remain challenging in this population. Imaging, electrocardiographic, and circulating biomarkers, as well as pharmacogenetics, may help to facilitate HF diagnosis, stratify risk, and individualize therapy. In this review, we focus on established and emerging circulating biomarkers in HF-PE, including circulating biomarkers of myocyte stress, myocyte injury, renal function, systemic inflammation, and fibrosis. Such markers have contributed to better understanding of the pathophysiologic mechanisms relevant to HF-PEF, and may eventually help to facilitate more effective and personalized management of this syndrome.

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Conflict of Interest

Eileen O’Meara has received compensation from Novartis, Servier, and Pfizer for service as a consultant, and is supported through grants from Servier and Johnson & Johnson.

Simon de Denus has received compensation from Servier for service as a consultant, is supported through grants from Pfizer, AstraZeneca, Roche, and Novartis, and has received payment for lectures including service on speaker bureaus from Pfizer.

Jean-Lucien Rouleau declares that he has no conflict of interest.

Akshay Desai has received compensation from Novartis, Boston Scientific, and Reata for service as a consultant; has received compensation from Rindler Morgan/Coverys for providing expert testimony; is supported through a grant from AtCor Medical, Inc.; and has received reimbursement for travel/accommodations/meeting expenses from Amgen.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Montreal Heart Institute, 5000 Belanger, Montreal, Canada, H1T 1C8

    Eileen O’Meara, Simon de Denus & Jean-Lucien Rouleau

  2. Université de Montréal, Montreal, Canada

    Eileen O’Meara, Simon de Denus & Jean-Lucien Rouleau

  3. Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Akshay Desai

  4. Harvard Medical School, Boston, MA, USA

    Akshay Desai

Authors
  1. Eileen O’Meara
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  2. Simon de Denus
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  3. Jean-Lucien Rouleau
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  4. Akshay Desai
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Correspondence to Eileen O’Meara.

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O’Meara, E., de Denus, S., Rouleau, JL. et al. Circulating Biomarkers in Patients with Heart Failure and Preserved Ejection Fraction. Curr Heart Fail Rep 10, 350–358 (2013). https://doi.org/10.1007/s11897-013-0160-x

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