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Mapping Lifestyle Interventions for Gestational Diabetes Prevention: A Scoping Review

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Abstract

Purpose of Review

The purpose of this study was to conduct a scoping review to map intervention, sample, and physiologic measurement characteristics of lifestyle interventions for gestational diabetes mellitus (GDM) prevention.

Recent Findings

A total of 19 studies met selection criteria from 405 articles screened (PubMed, Web of Science). No studies were US-based (47% multi-site), and all were delivered in clinical settings. The most targeted nutrition components were low carbohydrate intake (sugar rich foods/added sugars, low glycemic index), low fat intake (mainly low-fat meat, dairy, and saturated fat), and increased fruits and vegetables. Many studies promoted 150 min/week moderate-intensity physical activity. Only two studies provided supervised physical activity sessions. Dietitians and nurses were the most common implementers. Samples were characterized as adults with obesity (mean age 31 yr, BMI 31 kg/m2). Asian populations were predominantly studied. Four studies used theoretical frameworks (75% of which used Social Cognitive Theory). GDM diagnostic criteria set forth by the American Diabetes Association were the most widely used. Insulin sensitivity was commonly assessed via fasting indices.

Summary

There was a lack of multi-disciplinary, multi-level, and theory-based lifestyle interventions for reducing GDM risk. Addressing these gaps and prioritizing high-risk populations in the US with measurement of traditional and novel biomarkers will advance the field.

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Data Availability

Spreadsheets with data used in this study are publicly available at https://osf.io/gjw2n/.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Shah NS, et al. Trends in gestational diabetes at first live birth by race and ethnicity in the US, 2011–2019. JAMA. 2021;326(7):660–9. This study demonstrates the increasing trends in gestational diabetes mellitus in the United States and by racial/ethnic sub-groups.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Noctor E, Dunne FP. Type 2 diabetes after gestational diabetes: the influence of changing diagnostic criteria. World J Diabetes. 2015;6(2):234–44.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Li S, et al. Offspring risk of obesity in childhood, adolescence and adulthood in relation to gestational diabetes mellitus: a sex-specific association. Int J Epidemiol. 2017;46(5):1533–41.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Tam WH, et al. In utero exposure to maternal hyperglycemia increases childhood cardiometabolic risk in offspring. Diabetes Care. 2017;40(5):679–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Li W, et al. Maternal prepregnancy BMI and glucose level at 24–28 gestational weeks on offspring’s overweight status within 3 years of age. Biomed Res Int. 2017;2017:7607210.

    PubMed  PubMed Central  Google Scholar 

  6. American College of O, B-O. Gynecologists' Committee on Practice. Obesity in pregnancy: ACOG Practice Bulletin, Number 230. Obstet Gynecol. 2021;137(6):e128-e144.

  7. •• Cantor AG, et al. Counseling and behavioral interventions for healthy weight and weight gain in pregnancy: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2021;325(20):2094–109. This study by the US Preventive Services Task Force reviewed 68 intervention studies and found a significant reduction in gestational diabetes mellitus from lifestyle interventions.

    Article  PubMed  Google Scholar 

  8. Guo XY, et al. Improving the effectiveness of lifestyle interventions for gestational diabetes prevention: a meta-analysis and meta-regression. BJOG. 2019;126(3):311–20.

    Article  PubMed  Google Scholar 

  9. Bennett CJ, et al. Interventions designed to reduce excessive gestational weight gain can reduce the incidence of gestational diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials. Diabetes Res Clin Pract. 2018;141:69–79.

    Article  PubMed  Google Scholar 

  10. Rogozinska E, et al. Nutritional manipulation for the primary prevention of gestational diabetes mellitus: a meta-analysis of randomised studies. PLoS ONE. 2015;10(2):e0115526.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Madhuvrata P, et al. Prevention of gestational diabetes in pregnant women with risk factors for gestational diabetes: a systematic review and meta-analysis of randomised trials. Obstet Med. 2015;8(2):68–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. •• Griffith RJ, et al. Interventions to prevent women from developing gestational diabetes mellitus: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2020;6(6):CD012394. This study of 11 Cochrane Reviews that included 71 total trials found no clear benefit or harm of gestational diabetes prevention interventions, including exercise and diet.

  13. Group D.P.P.D.R. The Diabetes Prevention Program (DPP): description of lifestyle intervention. Diabetes Care 2002;25(12):2165–71

  14. Knowler WC, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393–403.

    Article  CAS  PubMed  Google Scholar 

  15. Aziz Z, et al. A systematic review of real-world diabetes prevention programs: learnings from the last 15 years. Implement Sci. 2015;10:172.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ackermann RT, O’Brien MJ. Evidence and challenges for translation and population impact of the diabetes prevention program. Curr Diab Rep. 2020;20(3):9.

    Article  PubMed  Google Scholar 

  17. Peters MDJ, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Implement. 2021;19(1):3–10.

    Article  PubMed  Google Scholar 

  18. Peters MDJ, et al. Scoping reviews: reinforcing and advancing the methodology and application. Syst Rev. 2021;10(1):263.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Tricco AC, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.

    Article  PubMed  Google Scholar 

  20. Peña A, Miller A. Mapping the characteristics of gestational diabetes prevention lifestyle interventions: a scoping review. 2022. https://doi.org/10.17605/OSF.IO/RW2UH.

  21. Koivusalo SB, et al. Gestational diabetes mellitus can be prevented by lifestyle intervention: the Finnish Gestational Diabetes Prevention Study (RADIEL): a randomized controlled trial. Diabetes Care. 2016;39(1):24–30.

    Article  MathSciNet  CAS  PubMed  Google Scholar 

  22. Luoto R, et al. Primary prevention of gestational diabetes mellitus and large-for-gestational-age newborns by lifestyle counseling: a cluster-randomized controlled trial. PLoS Med. 2011;8(5):e1001036.

    Article  MathSciNet  PubMed  PubMed Central  Google Scholar 

  23. Sagedal LR, et al. The effect of a prenatal lifestyle intervention on glucose metabolism: results of the Norwegian Fit for Delivery randomized controlled trial. BMC Pregnancy Childbirth. 2017;17(1):167.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Korpi-Hyovalti EA, et al. Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance. BMC Public Health. 2011;11:179.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Rono K, et al. Prevention of gestational diabetes with a prepregnancy lifestyle intervention - findings from a randomized controlled trial. Int J Womens Health. 2018;10:493–501.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Lin X, et al. Lifestyle intervention to prevent gestational diabetes mellitus and adverse maternal outcomes among pregnant women at high risk for gestational diabetes mellitus. J Int Med Res. 2020;48(12):300060520979130.

    Article  CAS  PubMed  Google Scholar 

  27. Ding B, et al. WeChat-assisted dietary and exercise intervention for prevention of gestational diabetes mellitus in overweight/obese pregnant women: a two-arm randomized clinical trial. Arch Gynecol Obstet. 2021;304(3):609–18.

    Article  PubMed  Google Scholar 

  28. Deng Y, et al. Effects of diet and exercise interventions to prevent gestational diabetes mellitus in pregnant women with high-risk factors in China: a randomized controlled study. Clin Nurs Res. 2022;31(5):836–47.

    Article  PubMed  Google Scholar 

  29. Chan RS, et al. Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong. Sci Rep. 2018;8(1):13849.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Poston L, et al. Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol. 2015;3(10):767–77.

    Article  PubMed  Google Scholar 

  31. Simmons D, et al. Effect of physical activity and/or healthy eating on GDM risk: the DALI Lifestyle Study. J Clin Endocrinol Metab. 2017;102(3):903–13.

    PubMed  Google Scholar 

  32. Petrella E, et al. Gestational weight gain in overweight and obese women enrolled in a healthy lifestyle and eating habits program. J Matern Fetal Neonatal Med. 2014;27(13):1348–52.

    Article  CAS  PubMed  Google Scholar 

  33. Bruno R, Petrella E, Bertarini V, Pedrielli G, Neri I, Facchinetti F. Adherence to a lifestyle programme in overweight/obese pregnant women and effect on gestational diabetes mellitus: a randomized controlled trial. Matern Child Nutr. 2017;13(3). https://doi.org/10.1111/mcn.12333.

  34. Motahari-Tabari NS, et al. The effectiveness of information-motivation-behavioral skills model on self-care practices in early pregnancy to prevent gestational diabetes mellitus in iranian overweight and obese women: a randomized controlled trial. Community Health Equity Res Policy. 2023;43(3):257–64.

    Article  PubMed  Google Scholar 

  35. Eslami E, et al. The effect of a lifestyle-based training package on weight gain and frequency of gestational diabetes in obese and overweight pregnant females. Iran Red Crescent Med J. 2018;20(S1):e62576.

    Google Scholar 

  36. Sadiya A, et al. Lifestyle intervention in early pregnancy can prevent gestational diabetes in high-risk pregnant women in the UAE: a randomized controlled trial. BMC Pregnancy Childbirth. 2022;22(1):668.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Kennelly MA, et al. Pregnancy exercise and nutrition with smartphone application support: a randomized controlled trial. Obstet Gynecol. 2018;131(5):818–26.

    Article  PubMed  Google Scholar 

  38. Harrison CL, et al. Optimizing healthy gestational weight gain in women at high risk of gestational diabetes: a randomized controlled trial. Obesity (Silver Spring). 2013;21(5):904–9.

    Article  PubMed  Google Scholar 

  39. Kunath J, et al. Effects of a lifestyle intervention during pregnancy to prevent excessive gestational weight gain in routine care - the cluster-randomised GeliS trial. BMC Med. 2019;17(1):5.

    Article  PubMed  PubMed Central  Google Scholar 

  40. International Association of D, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676–82.

  41. Organization W. H. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. 2013: Geneva.

  42. Matthews DR, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9.

    Article  CAS  PubMed  Google Scholar 

  43. Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The pathophysiology of gestational diabetes mellitus. Int J Mol Sci. 2018;19(11). https://doi.org/10.3390/ijms19113342.

  44. Ruiz JR, et al. Supervised exercise-based intervention to prevent excessive gestational weight gain: a randomized controlled trial. Mayo Clin Proc. 2013;88(12):1388–97.

    Article  PubMed  Google Scholar 

  45. Onaade O, et al. Physical activity for blood glucose control in gestational diabetes mellitus: rationale and recommendations for translational behavioral interventions. Clin Diabetes Endocrinol. 2021;7(1):7.

    Article  PubMed  PubMed Central  Google Scholar 

  46. ACOG Committee Opinion No. 804: Physical activity and exercise during pregnancy and the postpartum period: correction. Obstet Gynecol. 2021;138(4):683.

    Article  Google Scholar 

  47. Marshall NE, et al. The importance of nutrition in pregnancy and lactation: lifelong consequences. Am J Obstet Gynecol. 2022;226(5):607–32.

    Article  PubMed  Google Scholar 

  48. Rhodes EC, et al. Promoting equity in breastfeeding through peer counseling: the US Breastfeeding Heritage and Pride program. Int J Equity Health. 2021;20(1):128.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Chang YS, et al. Views and experiences of women, peer supporters and healthcare professionals on breastfeeding peer support: a systematic review of qualitative studies. Midwifery. 2022;108:103299.

    Article  PubMed  Google Scholar 

  50. Disparities, N.I.o.M.H.a.H. National institute of minority health and health disparities. (2017) NIMHD research framework. 2017 [cited 2023 May 1].  https://nimhd.nih.gov/researchFramework. Accessed 8 Aug 2023.

  51. Hill-Briggs F, Adler NE, Berkowitz SA, et al. Social determinants of health and diabetes: a scientific review. Diabetes care. 2020. https://doi.org/10.2337/dci20-0053.

  52. Clark ML, Utz SW. Social determinants of type 2 diabetes and health in the United States. World J Diabetes. 2014;5(3):296–304.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Phonyiam R. Barriers and facilitators to diabetes self-management in pregnant women with pre-existing type 2 diabetes mellitus: a scoping review. Curr diabetes rev. 2022. https://doi.org/10.2174/1573399819666220627111430.

  54. Phonyiam R, Berry DC. Racial and ethnic disparities in health care and health outcomes for pregnant women with diabetes. Nurs Womens Health. 2021;25(6):437–49.

    Article  PubMed  Google Scholar 

  55. Thornton PL, et al. New research directions on disparities in obesity and type 2 diabetes. Ann N Y Acad Sci. 2020;1461(1):5–24.

    Article  PubMed  Google Scholar 

  56. Roman CG, et al. The relation of the perceived environment to fear, physical activity, and health in public housing developments: evidence from Chicago. J Public Health Policy. 2009;30(Suppl 1):S286-308.

    Article  PubMed  Google Scholar 

  57. Roman CG, Chalfin A. Fear of walking outdoors. A multilevel ecologic analysis of crime and disorder. Am J Prev Med. 2008;34(4):306–12.

    Article  PubMed  Google Scholar 

  58. Geneshka M, Coventry P, Cruz J, Gilbody S. Relationship between green and blue spaces with mental and physical health: a systematic review of longitudinal observational studies. Int J Environ Res Public Health. 2021;18(17). https://doi.org/10.3390/ijerph18179010.

  59. Bancroft C, et al. Association of proximity and density of parks and objectively measured physical activity in the United States: a systematic review. Soc Sci Med. 2015;138:22–30.

    Article  PubMed  Google Scholar 

  60. Lee JLC, Lo TLT, Ho RTH. Understanding outdoor gyms in public open spaces: a systematic review and integrative synthesis of qualitative and quantitative evidence. Int J Environ Res Public Health. 2018;15(4). https://doi.org/10.3390/ijerph15040590.

  61. Stalsberg R, Pedersen AV. Are differences in physical activity across socioeconomic groups associated with choice of physical activity variables to report? Int J Environ Res Public Health. 2018;15(5). https://doi.org/10.3390/ijerph15050922.

  62. Gross RS, Mendelsohn AL, Arana MM, Messito MJ. Food insecurity during pregnancy and breastfeeding by low-income hispanic mothers. Pediatrics. 2019;143(6). https://doi.org/10.1542/peds.2018-4113.

  63. Di Renzo GC, Tosto V. Food insecurity, food deserts, reproduction and pregnancy: we should alert from now. J Matern Fetal Neonatal Med. 2022;35(25):9119–21.

    Article  PubMed  Google Scholar 

  64. National Academies of Sciences Engineering and Medicine (U.S.). Committee on Integrating Social Needs Care into the Delivery of Health Care to Improve the Nation's Health. Integrating social care into the delivery of health care : moving upstream to improve the nation's health. A consensus study report of the National Academies of Sciences, Engineering, Medicine. 2019, Washington, DC: the National Academies Press. xv, 177 pages.

  65. Reinoso D, et al. Addressing food insecurity: lessons learned from co-locating a food pantry with a federally qualified health center. Int J Integr Care. 2022;22(3):24.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Lim S, Takele WW, Vesco KK, Redman L, group APGpw, Josefson J. A systematic review and meta-analysis of participant characteristics in the prevention of gestational diabetes: a summary of evidence for precision medicine. medRxiv. 2023. https://doi.org/10.1101/2023.04.16.23288650.

  67. Sparks JR, et al. Lifestyle interventions in pregnancy targeting GDM prevention: looking ahead to precision medicine. Diabetologia. 2022;65(11):1814–24.

    Article  PubMed  Google Scholar 

  68. de Mendonca E, Fragoso MBT, de Oliveira JM, Xavier JA, Goulart MOF, de Oliveira ACM. Gestational diabetes mellitus: The crosslink among inflammation, nitroxidative stress, intestinal microbiota and alternative therapies. Antioxidants (Basel). 2022;11(1). https://doi.org/10.3390/antiox11010129.

  69. Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta. 2015;36(7):709–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Lekva T, et al. Impact of systemic inflammation on the progression of gestational diabetes mellitus. Curr Diab Rep. 2016;16(4):26.

    Article  PubMed  Google Scholar 

  71. Jadhav A, Khaire A, Joshi S. Exploring the role of oxidative stress, fatty acids and neurotrophins in gestational diabetes mellitus. Growth Factors. 2020;38(3–4):226–34.

    Article  CAS  PubMed  Google Scholar 

  72. Zhu W, et al. Epigenetic alternations of microRNAs and DNA methylation contribute to gestational diabetes mellitus. J Cell Mol Med. 2020;24(23):13899–912.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Dluski DF, Wolinska E, Skrzypczak M. Epigenetic changes in gestational diabetes mellitus. Int J Mol Sci. 2021;22(14). https://doi.org/10.3390/ijms22147649.

  74. Wang QY, et al. Current progress in metabolomics of gestational diabetes mellitus. World J Diabetes. 2021;12(8):1164–86.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Kemp L. Adaptation and fidelity: a recipe analogy for achieving both in population scale implementation. Prev Sci. 2016;17(4):429–38.

    Article  PubMed  Google Scholar 

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Acknowledgements

We are grateful to all researchers who conducted the studies that were available for review and the research participants that participated in them.

Funding

This work was funded, in part, by the Health Equity Advancing through Learning health system Research (HEAL-R) Collaborative, a partnership between IU Health’s Office of Health Equity Research and Engagement (HERE) and the Indiana University School of Medicine, generously funded by a Cook Group Incorporated Advances in Medicine (AIM) award.

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AP conceived of the study. AP and AMM served as primary reviewers and AGC as third reviewer. AP conducted the analysis and wrote the first draft of the manuscript with revisions from AMM, AGC, CMS, and RJH.

Corresponding author

Correspondence to Armando Peña.

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Peña, A., Miller, A.M., Campbell, A.G. et al. Mapping Lifestyle Interventions for Gestational Diabetes Prevention: A Scoping Review. Curr Diab Rep 24, 74–83 (2024). https://doi.org/10.1007/s11892-024-01535-5

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