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Glucose metabolism after pancreas-kidney transplantation

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Abstract

Simultaneous pancreas-kidney (SPK) transplantation is a promising treatment option for patients with type 1 diabetes and end-stage renal disease. Most of these patients can achieve normalization of glucose and hemoglobin A1c levels. Patient and graft survival continues to improve; however, defects in β-cell function and insulin resistance can be seen over time after transplant. Various methods can be used to assess the SPK recipient for the development of hyperglycemia and graft dysfunction, with treatment aimed at minimizing diabetogenic immunosuppression, using agents that may preserve β-cell function, and improving insulin resistance.

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  1. Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University, 1581 Dodd Drive, 491C McCampbell Hall, Columbus, OH, 43210, USA

    Elizabeth Diakoff

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  1. Elizabeth Diakoff
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Correspondence to Elizabeth Diakoff.

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Diakoff, E. Glucose metabolism after pancreas-kidney transplantation. Curr Diab Rep 8, 310–316 (2008). https://doi.org/10.1007/s11892-008-0055-5

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