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Phenotypes in Chronic Rhinosinusitis

  • Rhinitis, Conjunctivitis, and Sinusitis (J Oppenheimer and J Corrent, Section Editors)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Chronic rhinosinusitis (CRS) is a heterogenous disease process affecting a significant proportion of the population and impacting quality of life and productivity. Historically, CRS has been classified broadly into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Increased understanding regarding unique presentations of CRS subsets and their underlying inflammatory profiles has led to a new system for classifying CRS phenotypes.

Recent Findings

Consideration of CRS phenotypes has traditionally been a key factor in determining treatment paradigms. Under a new phenotype classification system, physical findings will continue to drive treatment decisions, but with more precision.

Summary

Recent rapidly accumulated knowledge indicates that the broad categorization of CRSwNP or CRSsNP is no longer clinically useful. Reorganization of CRS phenotypes and their underlying endotypes will lead to more targeted and efficacious therapy.

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Authors and Affiliations

  1. Department of Otolaryngology – Head and Neck Surgery, University of Alabama at Birmingham, 1720 Second Avenue South, Birmingham, AL, 35294, USA

    Justin P. McCormick, Harrison M. Thompson, Do-Yeon Cho, Bradford A. Woodworth & Jessica W. Grayson

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  1. Justin P. McCormick
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  2. Harrison M. Thompson
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  3. Do-Yeon Cho
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  4. Bradford A. Woodworth
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  5. Jessica W. Grayson
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Correspondence to Jessica W. Grayson.

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Dr. Woodworth is a consultant for Cook Medical, Smith and Nephew, and Baxter, outside the submitted work. The other authors declare no conflicts of interest relevant to this manuscript.

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McCormick, J.P., Thompson, H.M., Cho, DY. et al. Phenotypes in Chronic Rhinosinusitis. Curr Allergy Asthma Rep 20, 20 (2020). https://doi.org/10.1007/s11882-020-00916-6

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