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The Molecular Basis of Peanut Allergy

  • ALLERGENS (RK BUSH AND JA WOODFOLK, SECTION EDITORS)
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Abstract

Peanut allergens can trigger a potent and sometimes dangerous immune response in an increasing number of people. The molecular structures of these allergens form the basis for understanding this response. This review describes the currently known peanut allergen structures and discusses how modifications both enzymatic and non-enzymatic affect digestion, innate immune recognition, and IgE interactions. The allergen structures help explain cross-reactivity among allergens from different sources, which is useful in improving patient diagnostics. Surprisingly, it was recently noted that similar short peptide sequences among unrelated peanut allergens could also be a source of cross-reactivity. The molecular features of peanut allergens continue to inform predictions and provide new research directions in the study of allergic disease.

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Acknowledgments

The authors wish to thank Drs. Robert London, Michael Fessler, and Jason Williams for critical readings of the manuscript. This research was supported by Research Project Number Z01- ES102885-01 and ZIA- ES102645 in the Intramural Research Program of the National Institute of Environmental Health Sciences, National Institutes of Health.

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Conflict of Interest

Geoffrey A. Mueller, Soheila J. Maleki, and Lars C. Pedersen declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Laboratory of Structural Biology, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, MD-MR-01, Research Triangle Park, NC, 27709, USA

    Geoffrey A. Mueller & Lars C. Pedersen

  2. US Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA, USA

    Soheila J. Maleki

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  1. Geoffrey A. Mueller
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Correspondence to Geoffrey A. Mueller.

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Mueller, G.A., Maleki, S.J. & Pedersen, L.C. The Molecular Basis of Peanut Allergy. Curr Allergy Asthma Rep 14, 429 (2014). https://doi.org/10.1007/s11882-014-0429-5

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